Challenges in the Treatment of a Refractory Testicular Germ Cell Tumor in Young Patients with Imminent Organ Failure—A Case Report
Background/Aim: This case report navigates through the challenges of a complex clinical scenario involving germ cell tumors (GCTs), one of the most frequently encountered malignancies in adolescents and young adults. Case report: We present the case of an 18-year-old patient exhibiting atypical clin...
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2025-05-01
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| author | Iuliana Pantelimon Andra-Maria Stancu Claudiu Socoliuc Fikirie Abzait Irina Balescu Nicolae Bacalbasa Cristian Balalau Laurenţia Nicoleta Galeș Iulian Brezean |
| author_facet | Iuliana Pantelimon Andra-Maria Stancu Claudiu Socoliuc Fikirie Abzait Irina Balescu Nicolae Bacalbasa Cristian Balalau Laurenţia Nicoleta Galeș Iulian Brezean |
| author_sort | Iuliana Pantelimon |
| collection | DOAJ |
| description | Background/Aim: This case report navigates through the challenges of a complex clinical scenario involving germ cell tumors (GCTs), one of the most frequently encountered malignancies in adolescents and young adults. Case report: We present the case of an 18-year-old patient exhibiting atypical clinical manifestations, prompting emergent extensive surgical intervention. Upon admission to the Oncology Department, the adolescent presented with jaundice and dyspnea, being diagnosed with pure non-seminomatous embryonal carcinoma, a poor-risk prognosis group. Based on his prognostic group, the patient should have undergone chemotherapy with a well standardized regimen, but the imminent “liver visceral crisis” did not allow for the standard dose chemotherapy administration, so an adapted regimen of chemotherapy was considered and the full number of cycles was applied after this induction cycle. The treatment journey was protracted, emphasizing the need for early recognition and intervention in such cases. A comprehensive ongoing evaluation, including imagistic examinations and laboratory tests, revealed the presence of extensive refractory disease, which led to urgent treatment. Conclusions: This case provides valuable insights into the management of advanced testicular germ cell tumor in young patients facing imminent organ failure and underlines the importance of interdisciplinary collaboration. Understanding the complexities of this condition can aid in improving patient outcomes and enhancing the quality of care provided. |
| format | Article |
| id | doaj-art-d90bcf9ae4a042d5940582c3bcd00e7c |
| institution | Kabale University |
| issn | 2392-7674 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj-art-d90bcf9ae4a042d5940582c3bcd00e7c2025-08-20T03:27:37ZengMDPI AGJournal of Mind and Medical Sciences2392-76742025-05-011213010.3390/jmms12010030Challenges in the Treatment of a Refractory Testicular Germ Cell Tumor in Young Patients with Imminent Organ Failure—A Case ReportIuliana Pantelimon0Andra-Maria Stancu1Claudiu Socoliuc2Fikirie Abzait3Irina Balescu4Nicolae Bacalbasa5Cristian Balalau6Laurenţia Nicoleta Galeș7Iulian Brezean8Department of Oncology, “Dr. I. Cantacuzino” Clinical Hospital, 073206 Bucharest, RomaniaDepartment of Oncology, “Dr. I. Cantacuzino” Clinical Hospital, 073206 Bucharest, RomaniaDepartment of Pathology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Radiology, “Dr. I. Cantacuzino” Clinical Hospital, 073206 Bucharest, RomaniaDepartment of Surgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Surgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Surgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Oncology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Surgery, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaBackground/Aim: This case report navigates through the challenges of a complex clinical scenario involving germ cell tumors (GCTs), one of the most frequently encountered malignancies in adolescents and young adults. Case report: We present the case of an 18-year-old patient exhibiting atypical clinical manifestations, prompting emergent extensive surgical intervention. Upon admission to the Oncology Department, the adolescent presented with jaundice and dyspnea, being diagnosed with pure non-seminomatous embryonal carcinoma, a poor-risk prognosis group. Based on his prognostic group, the patient should have undergone chemotherapy with a well standardized regimen, but the imminent “liver visceral crisis” did not allow for the standard dose chemotherapy administration, so an adapted regimen of chemotherapy was considered and the full number of cycles was applied after this induction cycle. The treatment journey was protracted, emphasizing the need for early recognition and intervention in such cases. A comprehensive ongoing evaluation, including imagistic examinations and laboratory tests, revealed the presence of extensive refractory disease, which led to urgent treatment. Conclusions: This case provides valuable insights into the management of advanced testicular germ cell tumor in young patients facing imminent organ failure and underlines the importance of interdisciplinary collaboration. Understanding the complexities of this condition can aid in improving patient outcomes and enhancing the quality of care provided.https://www.mdpi.com/2392-7674/12/1/30embryonal carcinomatesticular cancervisceral crisismetastasesinduction chemotherapyhigh-dose chemotherapy |
| spellingShingle | Iuliana Pantelimon Andra-Maria Stancu Claudiu Socoliuc Fikirie Abzait Irina Balescu Nicolae Bacalbasa Cristian Balalau Laurenţia Nicoleta Galeș Iulian Brezean Challenges in the Treatment of a Refractory Testicular Germ Cell Tumor in Young Patients with Imminent Organ Failure—A Case Report Journal of Mind and Medical Sciences embryonal carcinoma testicular cancer visceral crisis metastases induction chemotherapy high-dose chemotherapy |
| title | Challenges in the Treatment of a Refractory Testicular Germ Cell Tumor in Young Patients with Imminent Organ Failure—A Case Report |
| title_full | Challenges in the Treatment of a Refractory Testicular Germ Cell Tumor in Young Patients with Imminent Organ Failure—A Case Report |
| title_fullStr | Challenges in the Treatment of a Refractory Testicular Germ Cell Tumor in Young Patients with Imminent Organ Failure—A Case Report |
| title_full_unstemmed | Challenges in the Treatment of a Refractory Testicular Germ Cell Tumor in Young Patients with Imminent Organ Failure—A Case Report |
| title_short | Challenges in the Treatment of a Refractory Testicular Germ Cell Tumor in Young Patients with Imminent Organ Failure—A Case Report |
| title_sort | challenges in the treatment of a refractory testicular germ cell tumor in young patients with imminent organ failure a case report |
| topic | embryonal carcinoma testicular cancer visceral crisis metastases induction chemotherapy high-dose chemotherapy |
| url | https://www.mdpi.com/2392-7674/12/1/30 |
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