Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies
The Transient Receptor Potential Melastatin 4 (TRPM4) is a transmembrane N-glycosylated ion channel that belongs to the large family of TRP proteins. It has an equal permeability to Na+ and K+ and is activated via an increase of the intracellular calcium concentration and membrane depolarization. Du...
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| Format: | Article |
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Wiley
2020-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2020/6615038 |
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| author | Mohamed-Yassine Amarouch Jaouad El Hilaly |
| author_facet | Mohamed-Yassine Amarouch Jaouad El Hilaly |
| author_sort | Mohamed-Yassine Amarouch |
| collection | DOAJ |
| description | The Transient Receptor Potential Melastatin 4 (TRPM4) is a transmembrane N-glycosylated ion channel that belongs to the large family of TRP proteins. It has an equal permeability to Na+ and K+ and is activated via an increase of the intracellular calcium concentration and membrane depolarization. Due to its wide distribution, TRPM4 dysfunction has been linked with several pathophysiological processes, including inherited cardiac arrhythmias. Many pathogenic variants of the TRPM4 gene have been identified in patients with different forms of cardiac disorders such as conduction defects, Brugada syndrome, and congenital long QT syndrome. At the cellular level, these variants induce either gain- or loss-of-function of TRPM4 channels for similar clinical phenotypes. However, the molecular mechanisms associating these functional alterations to the clinical phenotypes remain poorly understood. The main objective of this article is to review the major cardiac TRPM4 channelopathies and recent advances regarding their genetic background and the underlying molecular mechanisms. |
| format | Article |
| id | doaj-art-d9090f97f3dd4caa9d8ff24c936e7087 |
| institution | OA Journals |
| issn | 1755-5914 1755-5922 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-d9090f97f3dd4caa9d8ff24c936e70872025-08-20T02:21:11ZengWileyCardiovascular Therapeutics1755-59141755-59222020-01-01202010.1155/2020/66150386615038Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 ChannelopathiesMohamed-Yassine Amarouch0Jaouad El Hilaly1R.N.E Laboratory, Multidisciplinary Faculty of Taza, University of Sidi Mohamed Ben Abdellah, Fez, MoroccoR.N.E Laboratory, Multidisciplinary Faculty of Taza, University of Sidi Mohamed Ben Abdellah, Fez, MoroccoThe Transient Receptor Potential Melastatin 4 (TRPM4) is a transmembrane N-glycosylated ion channel that belongs to the large family of TRP proteins. It has an equal permeability to Na+ and K+ and is activated via an increase of the intracellular calcium concentration and membrane depolarization. Due to its wide distribution, TRPM4 dysfunction has been linked with several pathophysiological processes, including inherited cardiac arrhythmias. Many pathogenic variants of the TRPM4 gene have been identified in patients with different forms of cardiac disorders such as conduction defects, Brugada syndrome, and congenital long QT syndrome. At the cellular level, these variants induce either gain- or loss-of-function of TRPM4 channels for similar clinical phenotypes. However, the molecular mechanisms associating these functional alterations to the clinical phenotypes remain poorly understood. The main objective of this article is to review the major cardiac TRPM4 channelopathies and recent advances regarding their genetic background and the underlying molecular mechanisms.http://dx.doi.org/10.1155/2020/6615038 |
| spellingShingle | Mohamed-Yassine Amarouch Jaouad El Hilaly Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies Cardiovascular Therapeutics |
| title | Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies |
| title_full | Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies |
| title_fullStr | Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies |
| title_full_unstemmed | Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies |
| title_short | Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies |
| title_sort | inherited cardiac arrhythmia syndromes focus on molecular mechanisms underlying trpm4 channelopathies |
| url | http://dx.doi.org/10.1155/2020/6615038 |
| work_keys_str_mv | AT mohamedyassineamarouch inheritedcardiacarrhythmiasyndromesfocusonmolecularmechanismsunderlyingtrpm4channelopathies AT jaouadelhilaly inheritedcardiacarrhythmiasyndromesfocusonmolecularmechanismsunderlyingtrpm4channelopathies |