Improved Survival From Graft-versus-host Disease Following Pediatric Small Intestinal Transplantation Through Reduction in Systemic Immunosuppression Altering T-cell Chimerism Dynamics

Improved Survival From Graft-versus-host Disease Following Pediatric Small Intestinal Transplantation Through Reduction in Systemic Immunosuppression Altering T-cell Chimerism Dynamics

Background. Graft-versus-host-disease (GvHD) is an infrequent but serious complication of small intestinal transplantation in children, which is associated with a very poor prognosis. This study evaluated a novel strategy of managing GvHD in these patients through a reduction in immunosuppression. M...

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Main Authors: Sandeep Potluri, FRCPath, PhD, Sarah Lawson, FRCPath, Shyla Kishore, FRCPCH, Malobi Ogboli, FRCP, Jane Hartley, FRCPCH, Arun Alfred, FRCPath, Yvonne Wilson, FRCSG (Plast), Darius F. Mirza, FRCS, Khalid Sharif, FRCS, Girish Gupte, FRCPCH
Format: Article
Language:English
Published: Wolters Kluwer 2025-07-01
Series:Transplantation Direct
Online Access:http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001830
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