Clinical features and outcomes of pseudolithiasis induced by ceftriaxone in Chinese children: a single-center observational study
IntroductionCeftriaxone (CTX) is widely used in pediatric infectious disease treatment, although the diagnostic and therapeutic management of CTX-induced gallbladder pseudolithiasis (PL) remains challenging. In this study, we investigated the occurrence, clinical features, and management of CTX-indu...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1527014/full |
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| author | Chen Jin Chen Jin Wen-Li Xiu Wen-Li Xiu Yao Liu Yao Liu Xi-Wei Hao Qian Dong Qian Dong |
| author_facet | Chen Jin Chen Jin Wen-Li Xiu Wen-Li Xiu Yao Liu Yao Liu Xi-Wei Hao Qian Dong Qian Dong |
| author_sort | Chen Jin |
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| description | IntroductionCeftriaxone (CTX) is widely used in pediatric infectious disease treatment, although the diagnostic and therapeutic management of CTX-induced gallbladder pseudolithiasis (PL) remains challenging. In this study, we investigated the occurrence, clinical features, and management of CTX-induced PL in children.MethodsA retrospective case-control study was conducted on 185 pediatric patients receiving CTX at a single center. Data on treatment regimens, gallbladder imaging findings, and serum biochemical parameters post-CTX therapy were analyzed. Patients were classified into PL (n = 34) and non-PL (n = 151) groups based on imaging findings.ResultsPL was diagnosed in 18.4% of patients treated with CTX, primarily through ultrasound, which revealed hyperechoic material within the gallbladder. Compared with the non-PL group, patients with PL were older and taller, with no significant differences in CTX dosage (p = 0.915). Patients with PL also had higher rates of digestive and neurological infections (both p < 0.001). Serum analysis revealed distinct liver and kidney function markers in the PL group, including lower levels of total bile acids, adenosine deaminase, and lactate dehydrogenase, and higher creatinine levels (all p < 0.05). Discontinuation of CTX led to symptom resolution in most cases, and all cases of PL resolved within three months.ConclusionsThe occurrence of PL is not significantly related to CTX dosage. Furthermore, the rate of CTX metabolism and excretion may play a key role in PL development. Overall, the findings demonstrate that ultrasound is an effective tool for monitoring the development of PL in children receiving CTX and that discontinuation of CTX could be an effective treatment for PL. |
| format | Article |
| id | doaj-art-d9019eece54d4f82be4484213ff48d6b |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pediatrics |
| spelling | doaj-art-d9019eece54d4f82be4484213ff48d6b2025-01-17T06:50:50ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011310.3389/fped.2025.15270141527014Clinical features and outcomes of pseudolithiasis induced by ceftriaxone in Chinese children: a single-center observational studyChen Jin0Chen Jin1Wen-Li Xiu2Wen-Li Xiu3Yao Liu4Yao Liu5Xi-Wei Hao6Qian Dong7Qian Dong8Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaShandong Provincial Key Laboratory of Digital Medicine and Computer-Assisted Surgery, Qingdao University, Qingdao, Shandong, ChinaDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaShandong Provincial Key Laboratory of Digital Medicine and Computer-Assisted Surgery, Qingdao University, Qingdao, Shandong, ChinaDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaShandong Provincial Key Laboratory of Digital Medicine and Computer-Assisted Surgery, Qingdao University, Qingdao, Shandong, ChinaDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaShandong Provincial Key Laboratory of Digital Medicine and Computer-Assisted Surgery, Qingdao University, Qingdao, Shandong, ChinaIntroductionCeftriaxone (CTX) is widely used in pediatric infectious disease treatment, although the diagnostic and therapeutic management of CTX-induced gallbladder pseudolithiasis (PL) remains challenging. In this study, we investigated the occurrence, clinical features, and management of CTX-induced PL in children.MethodsA retrospective case-control study was conducted on 185 pediatric patients receiving CTX at a single center. Data on treatment regimens, gallbladder imaging findings, and serum biochemical parameters post-CTX therapy were analyzed. Patients were classified into PL (n = 34) and non-PL (n = 151) groups based on imaging findings.ResultsPL was diagnosed in 18.4% of patients treated with CTX, primarily through ultrasound, which revealed hyperechoic material within the gallbladder. Compared with the non-PL group, patients with PL were older and taller, with no significant differences in CTX dosage (p = 0.915). Patients with PL also had higher rates of digestive and neurological infections (both p < 0.001). Serum analysis revealed distinct liver and kidney function markers in the PL group, including lower levels of total bile acids, adenosine deaminase, and lactate dehydrogenase, and higher creatinine levels (all p < 0.05). Discontinuation of CTX led to symptom resolution in most cases, and all cases of PL resolved within three months.ConclusionsThe occurrence of PL is not significantly related to CTX dosage. Furthermore, the rate of CTX metabolism and excretion may play a key role in PL development. Overall, the findings demonstrate that ultrasound is an effective tool for monitoring the development of PL in children receiving CTX and that discontinuation of CTX could be an effective treatment for PL.https://www.frontiersin.org/articles/10.3389/fped.2025.1527014/fullceftriaxonegallbladder pseudolithiasispediatric infectious diseasesultrasound imagingserum biomarkers |
| spellingShingle | Chen Jin Chen Jin Wen-Li Xiu Wen-Li Xiu Yao Liu Yao Liu Xi-Wei Hao Qian Dong Qian Dong Clinical features and outcomes of pseudolithiasis induced by ceftriaxone in Chinese children: a single-center observational study Frontiers in Pediatrics ceftriaxone gallbladder pseudolithiasis pediatric infectious diseases ultrasound imaging serum biomarkers |
| title | Clinical features and outcomes of pseudolithiasis induced by ceftriaxone in Chinese children: a single-center observational study |
| title_full | Clinical features and outcomes of pseudolithiasis induced by ceftriaxone in Chinese children: a single-center observational study |
| title_fullStr | Clinical features and outcomes of pseudolithiasis induced by ceftriaxone in Chinese children: a single-center observational study |
| title_full_unstemmed | Clinical features and outcomes of pseudolithiasis induced by ceftriaxone in Chinese children: a single-center observational study |
| title_short | Clinical features and outcomes of pseudolithiasis induced by ceftriaxone in Chinese children: a single-center observational study |
| title_sort | clinical features and outcomes of pseudolithiasis induced by ceftriaxone in chinese children a single center observational study |
| topic | ceftriaxone gallbladder pseudolithiasis pediatric infectious diseases ultrasound imaging serum biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1527014/full |
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