Chemistry Behind the Immunomodulatory Activity of Astragalus membranaceus
Huang Qi (黄芪 Astragalus membranaceus) is a well-known and widely used herb in traditional Chinese medicine (TCM) tonic preparations. It has been used for many ailments over the last 2000 years. Flavonoids, saponins, and polysaccharides have been shown to be the main compounds responsible for the bio...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2021-12-01
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| Series: | Chinese Medicine and Culture |
| Online Access: | http://journals.lww.com/10.4103/CMAC.CMAC_40_21 |
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| author | Mallique Qader Jian Xu Yuejun Yang Xiaohua Wu Yuancai Liu Shugeng Cao |
| author_facet | Mallique Qader Jian Xu Yuejun Yang Xiaohua Wu Yuancai Liu Shugeng Cao |
| author_sort | Mallique Qader |
| collection | DOAJ |
| description | Huang Qi (黄芪 Astragalus membranaceus) is a well-known and widely used herb in traditional Chinese medicine (TCM) tonic preparations. It has been used for many ailments over the last 2000 years. Flavonoids, saponins, and polysaccharides have been shown to be the main compounds responsible for the biological and pharmacological activities, especially the immunomodulatory properties, of such tonic preparations. This review summarizes the published data on Astragalus extracts and fractions and the natural compounds responsible for the immunomodulatory activity with special reference to the modulation of nuclear factor-kappa B and related pathways (e.g., Nrf2). In addition, this review highlights the importance of Astragalus membranaceus in TCM for treating patients with diseases related to immunocompromised conditions, such as cancer and diabetes. |
| format | Article |
| id | doaj-art-d90134e7d2de4808b270ef03abe350ec |
| institution | OA Journals |
| issn | 2589-9627 2589-9473 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Chinese Medicine and Culture |
| spelling | doaj-art-d90134e7d2de4808b270ef03abe350ec2025-08-20T02:16:56ZengWolters Kluwer Health/LWWChinese Medicine and Culture2589-96272589-94732021-12-014420121010.4103/CMAC.CMAC_40_21CMAC-4-201Chemistry Behind the Immunomodulatory Activity of Astragalus membranaceusMallique Qader0Jian Xu1Yuejun Yang2Xiaohua Wu3Yuancai Liu4Shugeng Cao51 Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hawaii 96720, USA2 Hubei Provincial Key Laboratory of Quality and Safety of Traditional Chinese Medicine Health Food, Jing Brand Research Institute, Jing Brand Co., Ltd., Daye 435100, Hubei, China2 Hubei Provincial Key Laboratory of Quality and Safety of Traditional Chinese Medicine Health Food, Jing Brand Research Institute, Jing Brand Co., Ltd., Daye 435100, Hubei, China1 Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hawaii 96720, USA2 Hubei Provincial Key Laboratory of Quality and Safety of Traditional Chinese Medicine Health Food, Jing Brand Research Institute, Jing Brand Co., Ltd., Daye 435100, Hubei, China1 Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hawaii 96720, USAHuang Qi (黄芪 Astragalus membranaceus) is a well-known and widely used herb in traditional Chinese medicine (TCM) tonic preparations. It has been used for many ailments over the last 2000 years. Flavonoids, saponins, and polysaccharides have been shown to be the main compounds responsible for the biological and pharmacological activities, especially the immunomodulatory properties, of such tonic preparations. This review summarizes the published data on Astragalus extracts and fractions and the natural compounds responsible for the immunomodulatory activity with special reference to the modulation of nuclear factor-kappa B and related pathways (e.g., Nrf2). In addition, this review highlights the importance of Astragalus membranaceus in TCM for treating patients with diseases related to immunocompromised conditions, such as cancer and diabetes.http://journals.lww.com/10.4103/CMAC.CMAC_40_21 |
| spellingShingle | Mallique Qader Jian Xu Yuejun Yang Xiaohua Wu Yuancai Liu Shugeng Cao Chemistry Behind the Immunomodulatory Activity of Astragalus membranaceus Chinese Medicine and Culture |
| title | Chemistry Behind the Immunomodulatory Activity of Astragalus membranaceus |
| title_full | Chemistry Behind the Immunomodulatory Activity of Astragalus membranaceus |
| title_fullStr | Chemistry Behind the Immunomodulatory Activity of Astragalus membranaceus |
| title_full_unstemmed | Chemistry Behind the Immunomodulatory Activity of Astragalus membranaceus |
| title_short | Chemistry Behind the Immunomodulatory Activity of Astragalus membranaceus |
| title_sort | chemistry behind the immunomodulatory activity of astragalus membranaceus |
| url | http://journals.lww.com/10.4103/CMAC.CMAC_40_21 |
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