The Focal Induction of Reactive Oxygen Species in Rats as a Trigger of Aortic Valve Degeneration

The Focal Induction of Reactive Oxygen Species in Rats as a Trigger of Aortic Valve Degeneration

Background: Degenerative aortic valve disease (DAVD) is a multifactorial process. We developed an animal model to analyze the isolated, local effect of reactive oxygen species (ROS) on its pathophysiology. Methods: We utilized a photodynamic reaction (PDR) as a source of ROS in the aortic valve by a...

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Main Authors: Jessica Isabel Selig, Yukiharu Sugimura, Shintaro Katahira, Marco Polidori, Laura Alida Jacobi, Olga Medovoj, Sarah Betke, Mareike Barth, Artur Lichtenberg, Payam Akhyari, Jan-Philipp Minol
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antioxidants
Subjects:
reactive oxygen species
degenerative aortic valve disease
aortic valve stenosis
photodynamic reaction
mTHCP
temoporfin
Online Access:https://www.mdpi.com/2076-3921/13/12/1570
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