Aromatase Gene Expression in N-Ethyl-Nitrosamine-Induced Hepatocellular Carcinoma: Hepatoprotective Effects of Grape Seed Extract and Letrozole

Aromatase Gene Expression in N-Ethyl-Nitrosamine-Induced Hepatocellular Carcinoma: Hepatoprotective Effects of Grape Seed Extract and Letrozole

Objective: To determine the hepatoprotective properties of Letrozole alone and in combination with grape seed extract on hepatocellular carcinoma induced by N-Ethylnitrosamine in male albino Wistar rats. Methods: A quasi-experimental study was conducted at Sindh Agriculture University and Diagnosti...

Full description

Saved in:

Bibliographic Details
Main Authors:	Sadia Kazi, Sadia Tabassum, Bushra Sajid, Kishwar Lakhair, Shahnaz Bano, Mozna Talpur
Format:	Article
Language:	English
Published:	KARACHI MEDICAL AND DENTAL COLLEGE 2024-11-01
Series:	Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College
Subjects:	Aromatase, Hepatocellular carcinoma, Grape seed extract
Online Access:	https://www.annals-ashkmdc.org/index.php/ashkmdc/article/view/940
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Estrogen/androgen balance in men with hyperestrogenism normalized by using letrozole of the aromatase inhibitor drug class
by: Z. Sh. Pavlova, et al.
Published: (2022-03-01)

Benefits of aromatase blockers for increased testosterone in poultry: A mini-review
by: Rizki Fitrawan Yuneldi, et al.
Published: (2025-05-01)

Treatment Modalities for Aromatase Inhibitor-Associated Musculoskeletal Syndrome (AIMSS): A Scoping Review of Prospective Treatment Studies
by: Bobo JA, et al.
Published: (2025-04-01)

THE ROLE OF AROMATASE IN THE DEVELOPMENT OF ENDOMETRIOSIS
by: L. V. Adamyan, et al.
Published: (2017-03-01)

Toxic effects of monocrotophos and glyphosate on the female reproductive organ and aromatase gene expression in climbing perch
by: Sujata Mohapatra, et al.
Published: (2025-01-01)

Association between the aromatase (CYP19A1) gene variant rs10046 and cardiovascular risk in postmenopausal women
by: Betânia Rodrigues dos Santos, et al.
Published: (2025-01-01)

Selective estrogen receptor modulators and aromatase inhibitors in the treatment of functional male hypogonadism
by: Jakub Wydra, et al.
Published: (2025-08-01)

Determination and Disposition of the Aromatase Inhibitor Exemestane in CYP3A-Deficient Mice
by: Hanieh Taheri, et al.
Published: (2025-03-01)

Different Aspects of Letrozole Effect on Metabolism, Bone Health, Oxidative Stress and Prostate in the Intact Adult Dog
by: Zahra Dadvand, et al.
Published: (2025-07-01)

Two natural products from the seeds of Citrus reticulata Blanco (Rutaceae) inhibit estrogen biosynthesis by regulating the PI3K-aromatase pathway
by: Xing Yang, et al.
Published: (2025-06-01)

Comparative study of the efficacy of tamoxifen and aromatase inhibitors among breast cancer patients at Kenyatta National Hospital
by: Henry Gachoki Macharia, et al.
Published: (2025-08-01)

Plasma Proteomics and Metabolomics of Aromatase Inhibitors-Related Musculoskeletal Syndrome in Early Breast Cancer Patients
by: Feng Jing, et al.
Published: (2025-02-01)

Aromatase inhibitors can improve the semen quality of aged roosters by up regulating genes related to steroid hormone synthesis
by: Xuliang Luo, et al.
Published: (2024-12-01)

Sex-specific effects of exogenous asparagine on colorectal tumor growth, 17β-estradiol levels, and aromatase
by: Oladimeji Aladelokun, et al.
Published: (2025-05-01)

Aromatase inhibitors for short stature in male children and adolescents treated with growth hormone: a meta-analysis of randomized controlled trials
by: Kan Wang, et al.
Published: (2024-12-01)

Aromatase inhibitors therapy and major osteoporotic fracture risk in postmenopausal breast cancer patients: a nationwide real-world cohort study
by: Pin-Han Liu, et al.
Published: (2025-05-01)

Potential of Indole-3-Carbinol compounds from broccoli (Brassica oleracea var. italica) as natural aromatase blockers: In silico prediction and in vivo studies
by: Reski Amalia, et al.
Published: (2025-04-01)

The Bunch Grape
by: P.C. Andersen
Published: (2017-05-01)

Rheumatic aspects of arthralgias associated with aromatase inhibitor therapy (analysis of a clinical case series)
by: A. D. Koltakova, et al.
Published: (2023-02-01)

Cardiovascular and metabolic effects of ovarian suppression in combination with tamoxifen or an aromatase inhibitor as adjuvant therapy for early oestrogen receptor-positive breast cancer: a systematic review
by: Ying X. Gue, et al.
Published: (2024-07-01)

Effects of various rinsing conditions on residues of chlorpyrifos ethyl, acetamiprid and penconazole in grapes
by: Asiye Akyıldız
Published: (2014-05-01)

Aromatase reduces sperm motility by down-regulating the expression of proteins related to ATP synthesis in seminal plasma extracellular vesicles
by: Xuliang Luo, et al.
Published: (2025-03-01)

Effects of a Multimodal Program on Frailty Syndrome and Psychological Alterations in Breast Cancer Women Treated with Aromatase Inhibitors
by: Pedro Céspedes, et al.
Published: (2025-02-01)

Management of aromatase inhibitor-associated bone loss (AIBL) in women with hormone-sensitive breast cancer: An updated joint position statement of the IOF, CABS, ECTS, IEG, ESCEO, IMS, and SIOG
by: Peyman Hadji, et al.
Published: (2025-08-01)

Pilot Study of Cannabidiol for Treatment of Aromatase Inhibitor‐Associated Musculoskeletal Symptoms in Breast Cancer
by: Nicole M. G. Fleege, et al.
Published: (2025-08-01)

Lesson from a metastatic male breast cancer case: CDK4/6 plus aromatase inhibitors could not exceed tamoxifen
by: Tala Najdi, et al.
Published: (2025-05-01)

Similar fatty acid status of plasma lipids in postmenopausal women newly diagnosed with breast cancer and those receiving aromatase inhibitor therapy
by: Krstić Predrag, et al.
Published: (2021-01-01)

Younger tamoxifen-treated breast cancer patients also had higher risk of endometrial cancer and the risk could be reduced by sequenced aromatase inhibitor use: A population-based study in Taiwan
by: Sung-Chao Chu, et al.
Published: (2020-01-01)

Evaluation of dermatologic adverse events associated with aromatase inhibitors: insights from the FAERS database
by: Yuan-Yuan Wu, et al.
Published: (2025-05-01)

<i>Rosmarinus officinalis</i> L. as Fascinating Source of Potential Anticancer Agents Targeting Aromatase and COX-2: An Overview
by: Adriana Gargano, et al.
Published: (2025-04-01)

Impact of a Physical Exercise and Health Education Program on Metabolic Syndrome and Quality of Life in Postmenopausal Breast Cancer Women Undergoing Adjuvant Treatment with Aromatase Inhibitors
by: Pedro Cespedes, et al.
Published: (2024-11-01)

17β-Hydroxysteroid dehydrogenase type I and aromatase in ovarian cortical inclusion cysts
by: Enrique Pedernera, et al.
Published: (2025-03-01)

Real-world utilization of aromatase inhibitors, tamoxifen, and ovarian function suppression in premenopausal patients with early hormone receptor-positive, HER2-negative breast cancer with increased recurrence risk
by: Volkmar Müller, et al.
Published: (2025-06-01)

Analysis of grape fruits and grape seed for their major , minor and trace elemental contact by XRF technique
by: Baghdad Science Journal
Published: (2011-06-01)

Systematic literature review and trial-level meta-analysis of aromatase inhibitors vs tamoxifen in patients with HR+/HER2− early breast cancer
by: Wolfgang Janni, et al.
Published: (2025-06-01)

Valorization Pathway for Grape Pruning and Pomace Waste from the Wine Industry: Energy and Non-Energy Applications
by: José R. Ayala, et al.
Published: (2025-05-01)

From Fresh to Dried: Evaluating Drying Kinetics of Sultana and Besni Grapes
by: Mehmet Başlar
Published: (2023-06-01)

Yi Shen Tiao Gan decoction alleviates aromatase inhibitor–related bone loss by promoting H-type vessel formation
by: Meiling Chu, et al.
Published: (2025-05-01)

Exchange of Total Carbohydrate, Minerals, and Phenolics in Grape and Grape Products
by: Özlem Aras Aşcı, et al.
Published: (2021-07-01)

Effect of cell wall polysaccharides on the peelability in table grape berries
by: Boxiang Zhao, et al.
Published: (2025-05-01)