Curcumin ZnO and MgO Nanoparticles Confer Protective Effects Against Ketamine-Induced Bipolar Disorder in Mice: Role of Brain-Derived Neurotrophic Factor
Background: Bipolar disorder (BD), or bipolar disease, is a prevalent psychiatric condition. Current treatment options are often ineffective, with numerous side effects. Brain-derived neurotrophic factor (BDNF) may be a potential biomarker for BD. Materials and Methods: Synthesized curcumin-conjugat...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-06-01
|
| Series: | Advanced Biomedical Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/abr.abr_253_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849236361212592128 |
|---|---|
| author | Mahsa Salehirad Fatemehsadat Mobinhosseini A. Wallace Hayes Malak Hekmati Majid Motaghinejad Mohammad Yousefi |
| author_facet | Mahsa Salehirad Fatemehsadat Mobinhosseini A. Wallace Hayes Malak Hekmati Majid Motaghinejad Mohammad Yousefi |
| author_sort | Mahsa Salehirad |
| collection | DOAJ |
| description | Background:
Bipolar disorder (BD), or bipolar disease, is a prevalent psychiatric condition. Current treatment options are often ineffective, with numerous side effects. Brain-derived neurotrophic factor (BDNF) may be a potential biomarker for BD.
Materials and Methods:
Synthesized curcumin-conjugated ZnO nanoparticles (Cur-ZnO NPs) and curcumin-conjugated MgO nanoparticles (Cur-MgO NPs) were characterized by Fourier transform infrared, field emission scanning electron microscopy, (energy dispersive X-ray analysis (EDX), and ultraviolet-visible spectrophotometry. Behavioral changes in an open field test and the level of hippocampal BDNF were evaluated in a ketamine-induced manic-depressive-like behavior mouse model. Mice were treated intraperitoneal daily for 14 days. Control mice received saline; positive control mice received 25 mg/kg ketamine. Lithium (45 mg/kg), 5 mg/kg magnesium oxide (MgO), 5 mg/kg zinc oxide (ZnO), or 40 mg/kg curcumin was administrated in separates groups simultaneously with ketamine (25 mg/kg). Mice in the treatment group were given ketamine (25 mg/kg) plus Cur-MgO NPs or Cur-ZnO NPs (10, 20, or 40 mg/kg).
Results:
Both nanoparticles were chemically characterized. Both nanoparticles increased central square entries, time spent in the center zone, the rearing frequency, and ambulation distance in the ketamine-treated mice in the OFT. The hippocampal BDNF levels were also increased compared to the ketamine-treated mice.
Conclusion:
Cur-ZnO NPs and Cur-MgO NPs may be potential candidates for treating manic-depressive-like disorders. |
| format | Article |
| id | doaj-art-d8f7cf9395404fb29d2b74b1b4b56d84 |
| institution | Kabale University |
| issn | 2277-9175 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj-art-d8f7cf9395404fb29d2b74b1b4b56d842025-08-20T04:02:17ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752025-06-01141575710.4103/abr.abr_253_23Curcumin ZnO and MgO Nanoparticles Confer Protective Effects Against Ketamine-Induced Bipolar Disorder in Mice: Role of Brain-Derived Neurotrophic FactorMahsa SalehiradFatemehsadat MobinhosseiniA. Wallace HayesMalak HekmatiMajid MotaghinejadMohammad YousefiBackground: Bipolar disorder (BD), or bipolar disease, is a prevalent psychiatric condition. Current treatment options are often ineffective, with numerous side effects. Brain-derived neurotrophic factor (BDNF) may be a potential biomarker for BD. Materials and Methods: Synthesized curcumin-conjugated ZnO nanoparticles (Cur-ZnO NPs) and curcumin-conjugated MgO nanoparticles (Cur-MgO NPs) were characterized by Fourier transform infrared, field emission scanning electron microscopy, (energy dispersive X-ray analysis (EDX), and ultraviolet-visible spectrophotometry. Behavioral changes in an open field test and the level of hippocampal BDNF were evaluated in a ketamine-induced manic-depressive-like behavior mouse model. Mice were treated intraperitoneal daily for 14 days. Control mice received saline; positive control mice received 25 mg/kg ketamine. Lithium (45 mg/kg), 5 mg/kg magnesium oxide (MgO), 5 mg/kg zinc oxide (ZnO), or 40 mg/kg curcumin was administrated in separates groups simultaneously with ketamine (25 mg/kg). Mice in the treatment group were given ketamine (25 mg/kg) plus Cur-MgO NPs or Cur-ZnO NPs (10, 20, or 40 mg/kg). Results: Both nanoparticles were chemically characterized. Both nanoparticles increased central square entries, time spent in the center zone, the rearing frequency, and ambulation distance in the ketamine-treated mice in the OFT. The hippocampal BDNF levels were also increased compared to the ketamine-treated mice. Conclusion: Cur-ZnO NPs and Cur-MgO NPs may be potential candidates for treating manic-depressive-like disorders.https://journals.lww.com/10.4103/abr.abr_253_23bipolar disorderbrain-derived neurotrophic factornanoparticleopen field test |
| spellingShingle | Mahsa Salehirad Fatemehsadat Mobinhosseini A. Wallace Hayes Malak Hekmati Majid Motaghinejad Mohammad Yousefi Curcumin ZnO and MgO Nanoparticles Confer Protective Effects Against Ketamine-Induced Bipolar Disorder in Mice: Role of Brain-Derived Neurotrophic Factor Advanced Biomedical Research bipolar disorder brain-derived neurotrophic factor nanoparticle open field test |
| title | Curcumin ZnO and MgO Nanoparticles Confer Protective Effects Against Ketamine-Induced Bipolar Disorder in Mice: Role of Brain-Derived Neurotrophic Factor |
| title_full | Curcumin ZnO and MgO Nanoparticles Confer Protective Effects Against Ketamine-Induced Bipolar Disorder in Mice: Role of Brain-Derived Neurotrophic Factor |
| title_fullStr | Curcumin ZnO and MgO Nanoparticles Confer Protective Effects Against Ketamine-Induced Bipolar Disorder in Mice: Role of Brain-Derived Neurotrophic Factor |
| title_full_unstemmed | Curcumin ZnO and MgO Nanoparticles Confer Protective Effects Against Ketamine-Induced Bipolar Disorder in Mice: Role of Brain-Derived Neurotrophic Factor |
| title_short | Curcumin ZnO and MgO Nanoparticles Confer Protective Effects Against Ketamine-Induced Bipolar Disorder in Mice: Role of Brain-Derived Neurotrophic Factor |
| title_sort | curcumin zno and mgo nanoparticles confer protective effects against ketamine induced bipolar disorder in mice role of brain derived neurotrophic factor |
| topic | bipolar disorder brain-derived neurotrophic factor nanoparticle open field test |
| url | https://journals.lww.com/10.4103/abr.abr_253_23 |
| work_keys_str_mv | AT mahsasalehirad curcuminznoandmgonanoparticlesconferprotectiveeffectsagainstketamineinducedbipolardisorderinmiceroleofbrainderivedneurotrophicfactor AT fatemehsadatmobinhosseini curcuminznoandmgonanoparticlesconferprotectiveeffectsagainstketamineinducedbipolardisorderinmiceroleofbrainderivedneurotrophicfactor AT awallacehayes curcuminznoandmgonanoparticlesconferprotectiveeffectsagainstketamineinducedbipolardisorderinmiceroleofbrainderivedneurotrophicfactor AT malakhekmati curcuminznoandmgonanoparticlesconferprotectiveeffectsagainstketamineinducedbipolardisorderinmiceroleofbrainderivedneurotrophicfactor AT majidmotaghinejad curcuminznoandmgonanoparticlesconferprotectiveeffectsagainstketamineinducedbipolardisorderinmiceroleofbrainderivedneurotrophicfactor AT mohammadyousefi curcuminznoandmgonanoparticlesconferprotectiveeffectsagainstketamineinducedbipolardisorderinmiceroleofbrainderivedneurotrophicfactor |