Echocardiographic assessment of left atrial structural and functional changes after catheter ablation in paroxysmal atrial fibrillation with preserved ejection fraction
Abstract To evaluate dynamic changes in left atrial (LA) structure and function after catheter ablation in paroxysmal atrial fibrillation (PAF) patients with preserved ejection fraction using conventional echocardiography and 2D speckle-tracking imaging (2D-STI). Eighty-nine PAF patients underwent e...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-12908-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract To evaluate dynamic changes in left atrial (LA) structure and function after catheter ablation in paroxysmal atrial fibrillation (PAF) patients with preserved ejection fraction using conventional echocardiography and 2D speckle-tracking imaging (2D-STI). Eighty-nine PAF patients underwent echocardiography at 48 h pre-ablation, 1-day, 1-month, and 3-month post-ablation. Parameters included LA diameter (LAD), volume index (LAVI), strain (left atrial systolic strain (LASRs), early left atrial diastolic strain (LASRe), late left atrial diastolic strain (LASRa), and stiffness (LASt). At 1 day post-ablation, left ventricular ejection fraction (LVEF), peak early LA diastolic strain (LASRe), peak late LA diastolic strain (LASRa), and their strain rates were lower than baseline, while LA ejection fraction (LAEF) was higher (all P < 0.05). At 1 month and 3 months post-ablation, LA diameter (LAD), end-systolic/diastolic volumes, and volume index (LAVI) were significantly reduced, while left atrial appendage flow velocity (LAA-V), LAEF, LVEF, peak LA systolic strain (LASRs), and related strain rates were increased (all P < 0.05). Cox regression analysis showed that the 1-month LASRs recovery rate (ΔLASRs) was an independent predictor of AF recurrence (hazard ratio = 0.72, 95% confidence interval: 0.54–0.96, P = 0.023). After catheter ablation, LA reverse remodeling exhibits a pattern of “functional recovery preceding structural recovery”. The improvement in functional parameters at 1 month post-ablation is of significant value for predicting long-term prognosis. |
|---|---|
| ISSN: | 2045-2322 |