Single-access mini-PCNL with flexible cystoscopy vs. multi-access mini-PCNL for complex renal stones in prospective study
Abstract To observe the efficacy and safety of single-access minimally invasive percutaneous nephrolithotomy (MPCNL) combined with flexible cystoscopy and multi-access MPCNL in patients with complex renal stones (CRS). A total of 195 patients with CRS were prospectively randomized into two groups. N...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-15887-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849226385188454400 |
|---|---|
| author | Qing-lai Tang Jun-biao Ji Yun-yun Tu Ji-dong Guo Du-jian Wang Xing-zhu Zhou Rong-zhen Tao |
| author_facet | Qing-lai Tang Jun-biao Ji Yun-yun Tu Ji-dong Guo Du-jian Wang Xing-zhu Zhou Rong-zhen Tao |
| author_sort | Qing-lai Tang |
| collection | DOAJ |
| description | Abstract To observe the efficacy and safety of single-access minimally invasive percutaneous nephrolithotomy (MPCNL) combined with flexible cystoscopy and multi-access MPCNL in patients with complex renal stones (CRS). A total of 195 patients with CRS were prospectively randomized into two groups. Ninety-eight in the single-access MPCNL group and 97 cases as control in the multi-access MPCNL group. The stone-free rates (SFRs) at different times were considered as the primary outcome of the study. The secondary end points were operative time, hemoglobin decrease, postoperative hospital stay and operation-related complications. There was no obvious difference between two groups in patients’ demographics and preoperative clinical characteristics (All P > 0.05). Postoperative data showed that mean decrease in hemoglobin level was less in single-access MPCNL group than that in multi-access MPCNL group (P < 0.001). Postoperative hospital stay in single-access MPCNL group was more shorten than that in multi-access MPCNL group (P < 0.001). Moreover, the SFRs of the postoperative 2nd day and 4th week in single-access MPCNL group were both significantly higher than those in multi-access MPCNL group (Both P < 0.05). However, in terms of the rates of low back pain, perirenal hematoma and renal artery embolization, multi-access MPCNL group were all significantly higher than single-access MPCNL group (All P < 0.05). Our study shows that single-access MPCNL and flexible cystoscopy are ideal complementary techniques in the treatment of CRS, satisfying both high SFR and minimized renal injury. This method was safe and reproducible in clinical practice. |
| format | Article |
| id | doaj-art-d8f484cd6eba4e7a8fec3928022822a9 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d8f484cd6eba4e7a8fec3928022822a92025-08-24T11:22:17ZengNature PortfolioScientific Reports2045-23222025-08-011511810.1038/s41598-025-15887-9Single-access mini-PCNL with flexible cystoscopy vs. multi-access mini-PCNL for complex renal stones in prospective studyQing-lai Tang0Jun-biao Ji1Yun-yun Tu2Ji-dong Guo3Du-jian Wang4Xing-zhu Zhou5Rong-zhen Tao6Department of Urology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Anesthesiology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Anesthesiology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Anesthesiology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Urology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Urology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityDepartment of Urology, The Affiliated Jiangning Hospital of Nanjing Medical UniversityAbstract To observe the efficacy and safety of single-access minimally invasive percutaneous nephrolithotomy (MPCNL) combined with flexible cystoscopy and multi-access MPCNL in patients with complex renal stones (CRS). A total of 195 patients with CRS were prospectively randomized into two groups. Ninety-eight in the single-access MPCNL group and 97 cases as control in the multi-access MPCNL group. The stone-free rates (SFRs) at different times were considered as the primary outcome of the study. The secondary end points were operative time, hemoglobin decrease, postoperative hospital stay and operation-related complications. There was no obvious difference between two groups in patients’ demographics and preoperative clinical characteristics (All P > 0.05). Postoperative data showed that mean decrease in hemoglobin level was less in single-access MPCNL group than that in multi-access MPCNL group (P < 0.001). Postoperative hospital stay in single-access MPCNL group was more shorten than that in multi-access MPCNL group (P < 0.001). Moreover, the SFRs of the postoperative 2nd day and 4th week in single-access MPCNL group were both significantly higher than those in multi-access MPCNL group (Both P < 0.05). However, in terms of the rates of low back pain, perirenal hematoma and renal artery embolization, multi-access MPCNL group were all significantly higher than single-access MPCNL group (All P < 0.05). Our study shows that single-access MPCNL and flexible cystoscopy are ideal complementary techniques in the treatment of CRS, satisfying both high SFR and minimized renal injury. This method was safe and reproducible in clinical practice.https://doi.org/10.1038/s41598-025-15887-9Minimally invasive percutaneous nephrolithotomyFlexible cystoscopySingle-accessMulti-accessComplex renal stonesStone-free rates |
| spellingShingle | Qing-lai Tang Jun-biao Ji Yun-yun Tu Ji-dong Guo Du-jian Wang Xing-zhu Zhou Rong-zhen Tao Single-access mini-PCNL with flexible cystoscopy vs. multi-access mini-PCNL for complex renal stones in prospective study Scientific Reports Minimally invasive percutaneous nephrolithotomy Flexible cystoscopy Single-access Multi-access Complex renal stones Stone-free rates |
| title | Single-access mini-PCNL with flexible cystoscopy vs. multi-access mini-PCNL for complex renal stones in prospective study |
| title_full | Single-access mini-PCNL with flexible cystoscopy vs. multi-access mini-PCNL for complex renal stones in prospective study |
| title_fullStr | Single-access mini-PCNL with flexible cystoscopy vs. multi-access mini-PCNL for complex renal stones in prospective study |
| title_full_unstemmed | Single-access mini-PCNL with flexible cystoscopy vs. multi-access mini-PCNL for complex renal stones in prospective study |
| title_short | Single-access mini-PCNL with flexible cystoscopy vs. multi-access mini-PCNL for complex renal stones in prospective study |
| title_sort | single access mini pcnl with flexible cystoscopy vs multi access mini pcnl for complex renal stones in prospective study |
| topic | Minimally invasive percutaneous nephrolithotomy Flexible cystoscopy Single-access Multi-access Complex renal stones Stone-free rates |
| url | https://doi.org/10.1038/s41598-025-15887-9 |
| work_keys_str_mv | AT qinglaitang singleaccessminipcnlwithflexiblecystoscopyvsmultiaccessminipcnlforcomplexrenalstonesinprospectivestudy AT junbiaoji singleaccessminipcnlwithflexiblecystoscopyvsmultiaccessminipcnlforcomplexrenalstonesinprospectivestudy AT yunyuntu singleaccessminipcnlwithflexiblecystoscopyvsmultiaccessminipcnlforcomplexrenalstonesinprospectivestudy AT jidongguo singleaccessminipcnlwithflexiblecystoscopyvsmultiaccessminipcnlforcomplexrenalstonesinprospectivestudy AT dujianwang singleaccessminipcnlwithflexiblecystoscopyvsmultiaccessminipcnlforcomplexrenalstonesinprospectivestudy AT xingzhuzhou singleaccessminipcnlwithflexiblecystoscopyvsmultiaccessminipcnlforcomplexrenalstonesinprospectivestudy AT rongzhentao singleaccessminipcnlwithflexiblecystoscopyvsmultiaccessminipcnlforcomplexrenalstonesinprospectivestudy |