Combined association of triglyceride–glucose index and systemic inflammation index on all-cause and cardiovascular mortality
Abstract The triglyceride–glucose and systemic inflammation index have been linked to mortality outcomes. However, their combined impact on all-cause and cardiovascular mortality remains unclear. This study aimed to evaluate the individual and combined associations of the TyG index and SII with mort...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-06770-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849769041547231232 |
|---|---|
| author | Guanglei Liu Rise Zheng Qingyue Zeng Shuangqing Li Zhenmei An |
| author_facet | Guanglei Liu Rise Zheng Qingyue Zeng Shuangqing Li Zhenmei An |
| author_sort | Guanglei Liu |
| collection | DOAJ |
| description | Abstract The triglyceride–glucose and systemic inflammation index have been linked to mortality outcomes. However, their combined impact on all-cause and cardiovascular mortality remains unclear. This study aimed to evaluate the individual and combined associations of the TyG index and SII with mortality using data from NHANES. Associations between TyG, SII, and mortality were assessed using multivariable Cox proportional hazards models and restricted cubic spline (RCS) regression models. Subgroup and sensitivity analyses were also conducted. Compared to individuals with low TyG and low SII, those with high TyG and high SII had a hazard ratio (HR) of 1.29 (95% CI, 1.16–1.44) for all-cause mortality, 1.54 (95% CI, 1.23–1.94) for cardiovascular mortality, 1.56 (95% CI, 1.20–2.04) for cardiac mortality, and 1.60 (95% CI, 0.83–3.08) for cerebrovascular mortality after full adjustment. The ROC curve analysis indicated that the combination of TyG and SII had an AUC of 0.599 for predicting all-cause mortality and 0.613 for cardiovascular mortality. Subgroup and sensitivity analyses yielded consistent findings. In conclusion, these results underscore the significant combined association of the TyG index and SII on all-cause and cardiovascular mortality, highlighting the importance of jointly assessing these indices to better predict mortality outcomes. |
| format | Article |
| id | doaj-art-d8f30ce778fe41be811b5592d25ef2dd |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d8f30ce778fe41be811b5592d25ef2dd2025-08-20T03:03:36ZengNature PortfolioScientific Reports2045-23222025-07-0115111310.1038/s41598-025-06770-8Combined association of triglyceride–glucose index and systemic inflammation index on all-cause and cardiovascular mortalityGuanglei Liu0Rise Zheng1Qingyue Zeng2Shuangqing Li3Zhenmei An4Department of Endocrinology and Metabolism, West China Hospital, Sichuan UniversityGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan UniversityAbstract The triglyceride–glucose and systemic inflammation index have been linked to mortality outcomes. However, their combined impact on all-cause and cardiovascular mortality remains unclear. This study aimed to evaluate the individual and combined associations of the TyG index and SII with mortality using data from NHANES. Associations between TyG, SII, and mortality were assessed using multivariable Cox proportional hazards models and restricted cubic spline (RCS) regression models. Subgroup and sensitivity analyses were also conducted. Compared to individuals with low TyG and low SII, those with high TyG and high SII had a hazard ratio (HR) of 1.29 (95% CI, 1.16–1.44) for all-cause mortality, 1.54 (95% CI, 1.23–1.94) for cardiovascular mortality, 1.56 (95% CI, 1.20–2.04) for cardiac mortality, and 1.60 (95% CI, 0.83–3.08) for cerebrovascular mortality after full adjustment. The ROC curve analysis indicated that the combination of TyG and SII had an AUC of 0.599 for predicting all-cause mortality and 0.613 for cardiovascular mortality. Subgroup and sensitivity analyses yielded consistent findings. In conclusion, these results underscore the significant combined association of the TyG index and SII on all-cause and cardiovascular mortality, highlighting the importance of jointly assessing these indices to better predict mortality outcomes.https://doi.org/10.1038/s41598-025-06770-8Triglyceride–glucose indexInsulin resistanceSystemic inflammation indexInflammationMortality |
| spellingShingle | Guanglei Liu Rise Zheng Qingyue Zeng Shuangqing Li Zhenmei An Combined association of triglyceride–glucose index and systemic inflammation index on all-cause and cardiovascular mortality Scientific Reports Triglyceride–glucose index Insulin resistance Systemic inflammation index Inflammation Mortality |
| title | Combined association of triglyceride–glucose index and systemic inflammation index on all-cause and cardiovascular mortality |
| title_full | Combined association of triglyceride–glucose index and systemic inflammation index on all-cause and cardiovascular mortality |
| title_fullStr | Combined association of triglyceride–glucose index and systemic inflammation index on all-cause and cardiovascular mortality |
| title_full_unstemmed | Combined association of triglyceride–glucose index and systemic inflammation index on all-cause and cardiovascular mortality |
| title_short | Combined association of triglyceride–glucose index and systemic inflammation index on all-cause and cardiovascular mortality |
| title_sort | combined association of triglyceride glucose index and systemic inflammation index on all cause and cardiovascular mortality |
| topic | Triglyceride–glucose index Insulin resistance Systemic inflammation index Inflammation Mortality |
| url | https://doi.org/10.1038/s41598-025-06770-8 |
| work_keys_str_mv | AT guangleiliu combinedassociationoftriglycerideglucoseindexandsystemicinflammationindexonallcauseandcardiovascularmortality AT risezheng combinedassociationoftriglycerideglucoseindexandsystemicinflammationindexonallcauseandcardiovascularmortality AT qingyuezeng combinedassociationoftriglycerideglucoseindexandsystemicinflammationindexonallcauseandcardiovascularmortality AT shuangqingli combinedassociationoftriglycerideglucoseindexandsystemicinflammationindexonallcauseandcardiovascularmortality AT zhenmeian combinedassociationoftriglycerideglucoseindexandsystemicinflammationindexonallcauseandcardiovascularmortality |