RIPK1 in necroptosis and recent progress in related pharmaceutics

RIPK1 in necroptosis and recent progress in related pharmaceutics

Necroptosis is a programmed form of cell death. Receptor-interacting serine/threonine protein kinase l (RIPK1) is a crucial protein kinase that regulates the necroptosis pathway. Increased expression of death receptor family ligands such as tumor necrosis factor (TNF) increases the susceptibility of...

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Bibliographic Details
Main Authors: Kunhou Yao, Zhihao Shi, Fengya Zhao, Cong Tan, Yixin Zhang, Hao Fan, Yingzhe Wang, Xingwang Li, Jun Kong, Qun Wang, Dingxi Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
RIPK1
necroptosis
programmed cell death
inflammation
kinase domain
pharmaceutics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1480027/full
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