Natural products derived from traditional Chinese medicines targeting ER stress for the treatment of kidney diseases
Various factors, both internal and external, can disrupt endoplasmic reticulum (ER) homeostasis and increase the burden of protein folding, resulting in ER stress. While short periods of ER stress can help cells return to normal function, excessive or prolonged ER stress triggers a complex signaling...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2396446 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849688399109160960 |
|---|---|
| author | Mengping Wang Zhengtao Chen Ziru Tang Shiyun Tang |
| author_facet | Mengping Wang Zhengtao Chen Ziru Tang Shiyun Tang |
| author_sort | Mengping Wang |
| collection | DOAJ |
| description | Various factors, both internal and external, can disrupt endoplasmic reticulum (ER) homeostasis and increase the burden of protein folding, resulting in ER stress. While short periods of ER stress can help cells return to normal function, excessive or prolonged ER stress triggers a complex signaling network that negatively affects cells. Numerous studies have demonstrated the significant role of ER stress in various kidney diseases, such as immune-related kidney injury, diabetic kidney diseases, renal ischemia reperfusion injury, and renal fibrosis. To date, there is a severe shortage of medications for the treatment of acute and chronic kidney diseases of all causes. Natural products derived from various traditional Chinese medicines (TCM), which are a major source of new drugs, have garnered considerable attention. Recent research has revealed that many natural products have renoprotective effects by targeting ER stress-mediated events, such as apoptosis, oxidative stress, inflammation, autophagy, and epithelial-mesenchymal transition. This article provides a comprehensive review of the current research progress on natural products targeting ER stress for the treatment of kidney diseases. |
| format | Article |
| id | doaj-art-d8f035e8f64b4b5f8dccad6b6096d1dc |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-d8f035e8f64b4b5f8dccad6b6096d1dc2025-08-20T03:22:00ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2396446Natural products derived from traditional Chinese medicines targeting ER stress for the treatment of kidney diseasesMengping Wang0Zhengtao Chen1Ziru Tang2Shiyun Tang3Department of Nephrology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Cardiovascular, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, ChinaDepartment of Nephrology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaGCP Center, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaVarious factors, both internal and external, can disrupt endoplasmic reticulum (ER) homeostasis and increase the burden of protein folding, resulting in ER stress. While short periods of ER stress can help cells return to normal function, excessive or prolonged ER stress triggers a complex signaling network that negatively affects cells. Numerous studies have demonstrated the significant role of ER stress in various kidney diseases, such as immune-related kidney injury, diabetic kidney diseases, renal ischemia reperfusion injury, and renal fibrosis. To date, there is a severe shortage of medications for the treatment of acute and chronic kidney diseases of all causes. Natural products derived from various traditional Chinese medicines (TCM), which are a major source of new drugs, have garnered considerable attention. Recent research has revealed that many natural products have renoprotective effects by targeting ER stress-mediated events, such as apoptosis, oxidative stress, inflammation, autophagy, and epithelial-mesenchymal transition. This article provides a comprehensive review of the current research progress on natural products targeting ER stress for the treatment of kidney diseases.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2396446Natural productER stressunfolded protein responsekidney diseases |
| spellingShingle | Mengping Wang Zhengtao Chen Ziru Tang Shiyun Tang Natural products derived from traditional Chinese medicines targeting ER stress for the treatment of kidney diseases Renal Failure Natural product ER stress unfolded protein response kidney diseases |
| title | Natural products derived from traditional Chinese medicines targeting ER stress for the treatment of kidney diseases |
| title_full | Natural products derived from traditional Chinese medicines targeting ER stress for the treatment of kidney diseases |
| title_fullStr | Natural products derived from traditional Chinese medicines targeting ER stress for the treatment of kidney diseases |
| title_full_unstemmed | Natural products derived from traditional Chinese medicines targeting ER stress for the treatment of kidney diseases |
| title_short | Natural products derived from traditional Chinese medicines targeting ER stress for the treatment of kidney diseases |
| title_sort | natural products derived from traditional chinese medicines targeting er stress for the treatment of kidney diseases |
| topic | Natural product ER stress unfolded protein response kidney diseases |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2396446 |
| work_keys_str_mv | AT mengpingwang naturalproductsderivedfromtraditionalchinesemedicinestargetingerstressforthetreatmentofkidneydiseases AT zhengtaochen naturalproductsderivedfromtraditionalchinesemedicinestargetingerstressforthetreatmentofkidneydiseases AT zirutang naturalproductsderivedfromtraditionalchinesemedicinestargetingerstressforthetreatmentofkidneydiseases AT shiyuntang naturalproductsderivedfromtraditionalchinesemedicinestargetingerstressforthetreatmentofkidneydiseases |