The risk of heart-specific death in breast cancer patients
Abstract With the improvement of comprehensive anti-cancer treatment for breast cancer (BC), more and more BC survivors will die from non-cancer diseases, including cardiovascular disease dominated by heart disease (HD). Therefore, this study aimed to analyze the risk of heart-specific death (HSD) i...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-12648-6 |
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| author | Yunbo Luo Long Zhao Peng Qu Shiqi Han Yali Wang Xue Li Jun Liu Cui Ma Shishan Deng Qi Liang Lingmi Hou Panke Cheng |
| author_facet | Yunbo Luo Long Zhao Peng Qu Shiqi Han Yali Wang Xue Li Jun Liu Cui Ma Shishan Deng Qi Liang Lingmi Hou Panke Cheng |
| author_sort | Yunbo Luo |
| collection | DOAJ |
| description | Abstract With the improvement of comprehensive anti-cancer treatment for breast cancer (BC), more and more BC survivors will die from non-cancer diseases, including cardiovascular disease dominated by heart disease (HD). Therefore, this study aimed to analyze the risk of heart-specific death (HSD) in patients with BC by using the Surveillance, Epidemiology, and End Results (SEER) database. The eligible patients diagnosed with BC between 2000 and 2019 were exported from the SEER database. The standard mortality ratios (SMR) were calculated to compare the difference in HSD between patients with BC and the general population. The Cox Proportional hazard model was used to estimate the risk factors for HSD in BC patients and the 95% confidence intervals (CI) were calculated. Overall, 655,552 eligible patients were included in our study, and 149,708 (22.8%) patients died. Among the deaths, 22,718 (15.2%) cases were attributed HD which was the second cause of death for BC patients. With the extension of follow-up (> 10 years), HD surpassed breast cancer as the leading cause of death for BC (22.3% vs. 20.2%). The SMR for HD was 8.14 (95%CI: 8.04–8.25) in the whole cohort. Multivariate analysis showed that race, age, marital status, median household income, grade, stage and subtype were independent risk factors for HSD in BC patients. The risk of HSD is significantly higher in BC patients than in the general population and closely related to demographic characteristics and tumor clinicopathological factors. Medical approaches are needed to reduce the risk of HD among patients with BC. |
| format | Article |
| id | doaj-art-d8ef01276c8c43ecaf2f36161ca8dac5 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d8ef01276c8c43ecaf2f36161ca8dac52025-08-20T03:45:53ZengNature PortfolioScientific Reports2045-23222025-08-0115111010.1038/s41598-025-12648-6The risk of heart-specific death in breast cancer patientsYunbo Luo0Long Zhao1Peng Qu2Shiqi Han3Yali Wang4Xue Li5Jun Liu6Cui Ma7Shishan Deng8Qi Liang9Lingmi Hou10Panke Cheng11Department of Breast Surgery, Plastic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of ChinaDepartment of Neurosurgery, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical CollegeInstitute of Basic Medicine and Forensic Medicine, North Sichuan Medical CollegeDepartment of Academician (expert) Workstation, Biological Targeting Laboratory of Breast Cancer, Breast and Thyroid Surgery, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical CollegeInstitute of Cardiovascular Diseases, Department of Cardiology, School of Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Mathematics, Army Medical UniversityDepartment of Academician (expert) Workstation, Biological Targeting Laboratory of Breast Cancer, Breast and Thyroid Surgery, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical CollegeDepartment of Breast Surgery, Plastic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of ChinaInstitute of Cardiovascular Diseases, Department of Cardiology, School of Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaAbstract With the improvement of comprehensive anti-cancer treatment for breast cancer (BC), more and more BC survivors will die from non-cancer diseases, including cardiovascular disease dominated by heart disease (HD). Therefore, this study aimed to analyze the risk of heart-specific death (HSD) in patients with BC by using the Surveillance, Epidemiology, and End Results (SEER) database. The eligible patients diagnosed with BC between 2000 and 2019 were exported from the SEER database. The standard mortality ratios (SMR) were calculated to compare the difference in HSD between patients with BC and the general population. The Cox Proportional hazard model was used to estimate the risk factors for HSD in BC patients and the 95% confidence intervals (CI) were calculated. Overall, 655,552 eligible patients were included in our study, and 149,708 (22.8%) patients died. Among the deaths, 22,718 (15.2%) cases were attributed HD which was the second cause of death for BC patients. With the extension of follow-up (> 10 years), HD surpassed breast cancer as the leading cause of death for BC (22.3% vs. 20.2%). The SMR for HD was 8.14 (95%CI: 8.04–8.25) in the whole cohort. Multivariate analysis showed that race, age, marital status, median household income, grade, stage and subtype were independent risk factors for HSD in BC patients. The risk of HSD is significantly higher in BC patients than in the general population and closely related to demographic characteristics and tumor clinicopathological factors. Medical approaches are needed to reduce the risk of HD among patients with BC.https://doi.org/10.1038/s41598-025-12648-6 |
| spellingShingle | Yunbo Luo Long Zhao Peng Qu Shiqi Han Yali Wang Xue Li Jun Liu Cui Ma Shishan Deng Qi Liang Lingmi Hou Panke Cheng The risk of heart-specific death in breast cancer patients Scientific Reports |
| title | The risk of heart-specific death in breast cancer patients |
| title_full | The risk of heart-specific death in breast cancer patients |
| title_fullStr | The risk of heart-specific death in breast cancer patients |
| title_full_unstemmed | The risk of heart-specific death in breast cancer patients |
| title_short | The risk of heart-specific death in breast cancer patients |
| title_sort | risk of heart specific death in breast cancer patients |
| url | https://doi.org/10.1038/s41598-025-12648-6 |
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