Effect of metformin on the level of aqueous humor inflammatory cytokines in patients with cataract

Abstract This study investigated the content of inflammatory cytokines in the aqueous humor (AH) of cataract patients with type 2 diabetes (T2DM) and explored the effect of metformin on the level of cytokines. AH was collected from patients undergoing phacoemulsification and intraocular lens implant...

Full description

Saved in:
Bibliographic Details
Main Authors: Jiaxi Li, Jiarui Yang, Ziyuan Liu, Xuemin Li
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-024-81424-9
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832571828176945152
author Jiaxi Li
Jiarui Yang
Ziyuan Liu
Xuemin Li
author_facet Jiaxi Li
Jiarui Yang
Ziyuan Liu
Xuemin Li
author_sort Jiaxi Li
collection DOAJ
description Abstract This study investigated the content of inflammatory cytokines in the aqueous humor (AH) of cataract patients with type 2 diabetes (T2DM) and explored the effect of metformin on the level of cytokines. AH was collected from patients undergoing phacoemulsification and intraocular lens implantation in Peking University Third Hospital. Levels of cytokines were measured by Cytometric Bead Assay (CBA) Flex Set. Differences in level of AH cytokines were compared between patients using metformin and non-metformin medicine as blood sugar control drug for T2DM and age-related cataract patients without T2DM. A total of 67 patients were included, including 19 healthy controls, 33 patients in the metformin group, and 15 patients in the non-metformin group. The results showed that IL-6 levels were significantly higher in the non-metformin group than the metformin group and the healthy control group (p = 0.019 and 0.014, respectively). IFN-γ levels were also significantly higher in the non-metformin group than the metformin group and the healthy control group (p = 0.031 and 0.003, respectively). The levels of IL-10 in non-metformin group were significantly higher than those in the healthy control group (p = 0.008), whereas the levels of IL-10 showed no significant difference between metformin group and healthy controls. Metformin can reduce the level of cytokines in AH to a certain extent in cataract patients combined with T2DM. It is suggested that metformin may have preventive and therapeutic effects on the development of age-related cataract.
format Article
id doaj-art-d8ec59a25ec14e609ea1d1b09c8c9bbc
institution Kabale University
issn 2045-2322
language English
publishDate 2025-01-01
publisher Nature Portfolio
record_format Article
series Scientific Reports
spelling doaj-art-d8ec59a25ec14e609ea1d1b09c8c9bbc2025-02-02T12:17:59ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-024-81424-9Effect of metformin on the level of aqueous humor inflammatory cytokines in patients with cataractJiaxi Li0Jiarui Yang1Ziyuan Liu2Xuemin Li3Department of Ophthalmology, Peking University Third HospitalDepartment of Ophthalmology, Peking University Third HospitalDepartment of Ophthalmology, Peking University Third HospitalDepartment of Ophthalmology, Peking University Third HospitalAbstract This study investigated the content of inflammatory cytokines in the aqueous humor (AH) of cataract patients with type 2 diabetes (T2DM) and explored the effect of metformin on the level of cytokines. AH was collected from patients undergoing phacoemulsification and intraocular lens implantation in Peking University Third Hospital. Levels of cytokines were measured by Cytometric Bead Assay (CBA) Flex Set. Differences in level of AH cytokines were compared between patients using metformin and non-metformin medicine as blood sugar control drug for T2DM and age-related cataract patients without T2DM. A total of 67 patients were included, including 19 healthy controls, 33 patients in the metformin group, and 15 patients in the non-metformin group. The results showed that IL-6 levels were significantly higher in the non-metformin group than the metformin group and the healthy control group (p = 0.019 and 0.014, respectively). IFN-γ levels were also significantly higher in the non-metformin group than the metformin group and the healthy control group (p = 0.031 and 0.003, respectively). The levels of IL-10 in non-metformin group were significantly higher than those in the healthy control group (p = 0.008), whereas the levels of IL-10 showed no significant difference between metformin group and healthy controls. Metformin can reduce the level of cytokines in AH to a certain extent in cataract patients combined with T2DM. It is suggested that metformin may have preventive and therapeutic effects on the development of age-related cataract.https://doi.org/10.1038/s41598-024-81424-9MetforminCytokinesCataract
spellingShingle Jiaxi Li
Jiarui Yang
Ziyuan Liu
Xuemin Li
Effect of metformin on the level of aqueous humor inflammatory cytokines in patients with cataract
Scientific Reports
Metformin
Cytokines
Cataract
title Effect of metformin on the level of aqueous humor inflammatory cytokines in patients with cataract
title_full Effect of metformin on the level of aqueous humor inflammatory cytokines in patients with cataract
title_fullStr Effect of metformin on the level of aqueous humor inflammatory cytokines in patients with cataract
title_full_unstemmed Effect of metformin on the level of aqueous humor inflammatory cytokines in patients with cataract
title_short Effect of metformin on the level of aqueous humor inflammatory cytokines in patients with cataract
title_sort effect of metformin on the level of aqueous humor inflammatory cytokines in patients with cataract
topic Metformin
Cytokines
Cataract
url https://doi.org/10.1038/s41598-024-81424-9
work_keys_str_mv AT jiaxili effectofmetforminonthelevelofaqueoushumorinflammatorycytokinesinpatientswithcataract
AT jiaruiyang effectofmetforminonthelevelofaqueoushumorinflammatorycytokinesinpatientswithcataract
AT ziyuanliu effectofmetforminonthelevelofaqueoushumorinflammatorycytokinesinpatientswithcataract
AT xueminli effectofmetforminonthelevelofaqueoushumorinflammatorycytokinesinpatientswithcataract