Association of epicardial fat volume with the severity of coronary artery disease: a preliminary study on risk prediction of obstructive coronary heart disease
Abstract Background We aimed to explore the correlation between epicardial fat volume (EFV) and the severity of coronary atherosclerotic artery disease (CAD), evaluate the predictive value of EFV for obstructive CAD, and provide prediction for the selection of clinical treatment schemes for CAD. Met...
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BMC
2025-04-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04743-3 |
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| author | Hangyi Zhou Yuxin Pan Juan Du Fen Liang Xiaojun Ma Dongling Lv |
| author_facet | Hangyi Zhou Yuxin Pan Juan Du Fen Liang Xiaojun Ma Dongling Lv |
| author_sort | Hangyi Zhou |
| collection | DOAJ |
| description | Abstract Background We aimed to explore the correlation between epicardial fat volume (EFV) and the severity of coronary atherosclerotic artery disease (CAD), evaluate the predictive value of EFV for obstructive CAD, and provide prediction for the selection of clinical treatment schemes for CAD. Methods A total of 203 patients undergoing chest computed tomography (CT) and Coronary Artery Angiography (CAG) were included in this retrospective study. The severity of coronary stenosis and SYNTAX score were evaluated by CAG images. There were 141 patients in obstructive CAD group which was defined as coronary stenosis severity ≥ 70% and 62 patients in non obstructive CAD group. Results Multivariate logistic regression analysis showed that after adjusting for confounding factors, EFV (OR, 1.008; 95% CI, 1.000-1.016; p = 0.039) was an independent risk factor for obstructive CAD. Spearman correlation analysis showed a significant positive correlation between EFV and SYNTAX score, as well as the number of coronary lesions (r = 0.157, p = 0.026; r = 0.231, p = 0.002). The EFV of males was significantly higher than that of females (p < 0.001). EFV was significantly positively correlated with intrathoracic fat volume (IFV) (p < 0.001). Conclusions EFV maybe an independent risk factor for obstructive CAD. Quantitative measurement of EFV by QCT can predict the severity of CAD. EFV was significantly correlated with IFV, but not with BMI. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-d8e1441409f84a3482f6a8b3870da367 |
| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-d8e1441409f84a3482f6a8b3870da3672025-08-20T03:04:16ZengBMCBMC Cardiovascular Disorders1471-22612025-04-0125111210.1186/s12872-025-04743-3Association of epicardial fat volume with the severity of coronary artery disease: a preliminary study on risk prediction of obstructive coronary heart diseaseHangyi Zhou0Yuxin Pan1Juan Du2Fen Liang3Xiaojun Ma4Dongling Lv5Changhai Hospital, Naval Medical UniversityAffiliated Hospital of Nanjing University of Chinese MedicineChanghai Hospital, Naval Medical UniversityAffiliated Hospital of Nanjing University of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineAbstract Background We aimed to explore the correlation between epicardial fat volume (EFV) and the severity of coronary atherosclerotic artery disease (CAD), evaluate the predictive value of EFV for obstructive CAD, and provide prediction for the selection of clinical treatment schemes for CAD. Methods A total of 203 patients undergoing chest computed tomography (CT) and Coronary Artery Angiography (CAG) were included in this retrospective study. The severity of coronary stenosis and SYNTAX score were evaluated by CAG images. There were 141 patients in obstructive CAD group which was defined as coronary stenosis severity ≥ 70% and 62 patients in non obstructive CAD group. Results Multivariate logistic regression analysis showed that after adjusting for confounding factors, EFV (OR, 1.008; 95% CI, 1.000-1.016; p = 0.039) was an independent risk factor for obstructive CAD. Spearman correlation analysis showed a significant positive correlation between EFV and SYNTAX score, as well as the number of coronary lesions (r = 0.157, p = 0.026; r = 0.231, p = 0.002). The EFV of males was significantly higher than that of females (p < 0.001). EFV was significantly positively correlated with intrathoracic fat volume (IFV) (p < 0.001). Conclusions EFV maybe an independent risk factor for obstructive CAD. Quantitative measurement of EFV by QCT can predict the severity of CAD. EFV was significantly correlated with IFV, but not with BMI. Clinical trial number Not applicable.https://doi.org/10.1186/s12872-025-04743-3Epicardial adipose tissueObstructive coronary heart diseaseSYNTAX scoreStenosisQuantitative computed tomographyObesity |
| spellingShingle | Hangyi Zhou Yuxin Pan Juan Du Fen Liang Xiaojun Ma Dongling Lv Association of epicardial fat volume with the severity of coronary artery disease: a preliminary study on risk prediction of obstructive coronary heart disease BMC Cardiovascular Disorders Epicardial adipose tissue Obstructive coronary heart disease SYNTAX score Stenosis Quantitative computed tomography Obesity |
| title | Association of epicardial fat volume with the severity of coronary artery disease: a preliminary study on risk prediction of obstructive coronary heart disease |
| title_full | Association of epicardial fat volume with the severity of coronary artery disease: a preliminary study on risk prediction of obstructive coronary heart disease |
| title_fullStr | Association of epicardial fat volume with the severity of coronary artery disease: a preliminary study on risk prediction of obstructive coronary heart disease |
| title_full_unstemmed | Association of epicardial fat volume with the severity of coronary artery disease: a preliminary study on risk prediction of obstructive coronary heart disease |
| title_short | Association of epicardial fat volume with the severity of coronary artery disease: a preliminary study on risk prediction of obstructive coronary heart disease |
| title_sort | association of epicardial fat volume with the severity of coronary artery disease a preliminary study on risk prediction of obstructive coronary heart disease |
| topic | Epicardial adipose tissue Obstructive coronary heart disease SYNTAX score Stenosis Quantitative computed tomography Obesity |
| url | https://doi.org/10.1186/s12872-025-04743-3 |
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