Bone regeneration using moldable calcium phosphate with and without recombinant human BMP-2 in a rabbit critical-sized metaphyseal core defect model

Bone regeneration using moldable calcium phosphate with and without recombinant human BMP-2 in a rabbit critical-sized metaphyseal core defect model

Abstract Background Moldable calcium phosphate (MCaP) biomaterials have been studied as osteoconductive scaffolds for bone regeneration. However, their potential as carriers for recombinant human bone morphogenetic protein-2 (rhBMP-2) and the biological impact of varying rhBMP-2 doses remain to be f...

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Bibliographic Details
Main Authors: Hyun Seung Ryu, Hyun Jung Park, Mi Young Ryu, Young-Hoon Kim, Sang-Il Kim, Hyung-Youl Park
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Bone regeneration
Critical-sized defect
Metaphyseal bone
Moldable calcium phosphate
Recombinant human bone morphogenetic protein-2 (rhBMP-2)
Bone graft substitute
Online Access:https://doi.org/10.1186/s13018-025-05966-y
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