Lamina cribrosa morphology and clinical implications in glaucoma with thin central corneal thickness
Abstract This study investigated the relationship between thin central corneal thickness (CCT) and lamina cribrosa (LC) morphology in patients with normal-tension glaucoma. Thin CCT was defined as a corneal thickness of less than 500 μm in both eyes, and all included patients had a corrected intraoc...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-06069-8 |
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| author | Sang Muk Lee Min Seon Park Garam Shin Sung Uk Baek |
| author_facet | Sang Muk Lee Min Seon Park Garam Shin Sung Uk Baek |
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| description | Abstract This study investigated the relationship between thin central corneal thickness (CCT) and lamina cribrosa (LC) morphology in patients with normal-tension glaucoma. Thin CCT was defined as a corneal thickness of less than 500 μm in both eyes, and all included patients had a corrected intraocular pressure of less than 20 mmHg. To investigate the LC-morphological characteristics observed in the Thin-CCT group (N = 60), the Normal-CCT group (N = 36) was set as the control. A subgroup analysis was performed on Progressors and Non-progressors using the visual field’s progression rate to identify progression-related risk factors. The LC posterior displacement index was higher in the Thin-CCT group and the temporal anterior laminar insertion depth (ALID) was deeper in Progressors. In multivariate analyses, the risk of glaucoma progression increased with older age, thinner CCT, worse visual filed, deeper temporal ALID, and deeper mean LC depth. Notably, ALID showed a significant correlation with CCT. These findings suggest that in patients with normal-tension glaucoma, thinner CCT is associated with a more pronounced posterior displacement and deeper insertion of the LC, even under similar intraocular pressure conditions. The altered LC morphology observed in thin CCT may help explain the higher rate of glaucoma progression in this patient population. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-d8dfa790a6a44153b76a2e3df17074a02025-08-20T03:37:31ZengNature PortfolioScientific Reports2045-23222025-07-011511810.1038/s41598-025-06069-8Lamina cribrosa morphology and clinical implications in glaucoma with thin central corneal thicknessSang Muk Lee0Min Seon Park1Garam Shin2Sung Uk Baek3Department of Ophthalmology, Hallym University College of MedicineDepartment of Ophthalmology, Hallym University College of MedicineDepartment of Ophthalmology, Hallym University College of MedicineDepartment of Ophthalmology, Hallym University College of MedicineAbstract This study investigated the relationship between thin central corneal thickness (CCT) and lamina cribrosa (LC) morphology in patients with normal-tension glaucoma. Thin CCT was defined as a corneal thickness of less than 500 μm in both eyes, and all included patients had a corrected intraocular pressure of less than 20 mmHg. To investigate the LC-morphological characteristics observed in the Thin-CCT group (N = 60), the Normal-CCT group (N = 36) was set as the control. A subgroup analysis was performed on Progressors and Non-progressors using the visual field’s progression rate to identify progression-related risk factors. The LC posterior displacement index was higher in the Thin-CCT group and the temporal anterior laminar insertion depth (ALID) was deeper in Progressors. In multivariate analyses, the risk of glaucoma progression increased with older age, thinner CCT, worse visual filed, deeper temporal ALID, and deeper mean LC depth. Notably, ALID showed a significant correlation with CCT. These findings suggest that in patients with normal-tension glaucoma, thinner CCT is associated with a more pronounced posterior displacement and deeper insertion of the LC, even under similar intraocular pressure conditions. The altered LC morphology observed in thin CCT may help explain the higher rate of glaucoma progression in this patient population.https://doi.org/10.1038/s41598-025-06069-8Central corneal thicknessLamina cribrosaPosterior displacement indexAnterior laminar insertion depth |
| spellingShingle | Sang Muk Lee Min Seon Park Garam Shin Sung Uk Baek Lamina cribrosa morphology and clinical implications in glaucoma with thin central corneal thickness Scientific Reports Central corneal thickness Lamina cribrosa Posterior displacement index Anterior laminar insertion depth |
| title | Lamina cribrosa morphology and clinical implications in glaucoma with thin central corneal thickness |
| title_full | Lamina cribrosa morphology and clinical implications in glaucoma with thin central corneal thickness |
| title_fullStr | Lamina cribrosa morphology and clinical implications in glaucoma with thin central corneal thickness |
| title_full_unstemmed | Lamina cribrosa morphology and clinical implications in glaucoma with thin central corneal thickness |
| title_short | Lamina cribrosa morphology and clinical implications in glaucoma with thin central corneal thickness |
| title_sort | lamina cribrosa morphology and clinical implications in glaucoma with thin central corneal thickness |
| topic | Central corneal thickness Lamina cribrosa Posterior displacement index Anterior laminar insertion depth |
| url | https://doi.org/10.1038/s41598-025-06069-8 |
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