Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis

Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis

Allergic rhinitis (AR), a globally prevalent immune-mediated inflammatory condition, is still an incurable disease. In the present study, we have validated the impact of the Kelch-like ECH associated protein 1 (Keap1)-related oxidative stress and inflammatory response in clinical AR patient peripher...

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Bibliographic Details
Main Authors: Jianyu Yan, Tianyu Wang, Ruizhi Yu, Lijuan Xu, Hongming Shao, Tengfei Li, Zhe Wang, Xudong Cha, Zhenyuan Miao, Chengguo Xing, Ke Xu, Huanhai Liu, Chunlin Zhuang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Allergic rhinitis
Keap1
Nrf2
E3 ligase
Degradation
HomoPROTAC
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525003314
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