The role of netrin G1-netrin-G-ligand-1 in schizophrenia
Schizophrenia (SCZ) is a chronic psychotic disorder that profoundly alters an individual’s perception of reality, resulting in abnormal behavior, cognitive deficits, thought distortions, and disorientation in emotions. Many complicated factors can lead to SCZ, and investigations are ongoing to under...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-01-01
|
| Series: | Tzu Chi Medical Journal |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/tcmj.tcmj_83_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849473127428390912 |
|---|---|
| author | Ayooluwa Gabriel Ibiayo Luo-Zhu Yang Ingrid Y. Liu |
| author_facet | Ayooluwa Gabriel Ibiayo Luo-Zhu Yang Ingrid Y. Liu |
| author_sort | Ayooluwa Gabriel Ibiayo |
| collection | DOAJ |
| description | Schizophrenia (SCZ) is a chronic psychotic disorder that profoundly alters an individual’s perception of reality, resulting in abnormal behavior, cognitive deficits, thought distortions, and disorientation in emotions. Many complicated factors can lead to SCZ, and investigations are ongoing to understand the neurobiological underpinnings of this condition. Presynaptic Netrin G1 and its cognate partner postsynaptic Netrin-G-Ligand-1 (NGL-1) have been implicated in SCZ. This review article emphasized the structure and expression of Netrin G1/NGL-1 in the brain, its dysregulation in SCZ patients, and its role in synaptic plasticity, synaptic interaction, learning and memory, microglia neurotrophic activity, and possible signaling between Netrin G1/NGL-1, postsynaptic density protein 95, and cyclin-dependent kinase-like 5 in synaptic morphogenesis. Pharmaceutical targets and the potential use of Netrin G1/NGL-1 as treatment targets or biomarkers for SCZ were also discussed. |
| format | Article |
| id | doaj-art-d8d9e20c50f74432a2c545b6a6f82650 |
| institution | Kabale University |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-d8d9e20c50f74432a2c545b6a6f826502025-08-20T03:24:16ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562025-01-013711910.4103/tcmj.tcmj_83_24The role of netrin G1-netrin-G-ligand-1 in schizophreniaAyooluwa Gabriel IbiayoLuo-Zhu YangIngrid Y. LiuSchizophrenia (SCZ) is a chronic psychotic disorder that profoundly alters an individual’s perception of reality, resulting in abnormal behavior, cognitive deficits, thought distortions, and disorientation in emotions. Many complicated factors can lead to SCZ, and investigations are ongoing to understand the neurobiological underpinnings of this condition. Presynaptic Netrin G1 and its cognate partner postsynaptic Netrin-G-Ligand-1 (NGL-1) have been implicated in SCZ. This review article emphasized the structure and expression of Netrin G1/NGL-1 in the brain, its dysregulation in SCZ patients, and its role in synaptic plasticity, synaptic interaction, learning and memory, microglia neurotrophic activity, and possible signaling between Netrin G1/NGL-1, postsynaptic density protein 95, and cyclin-dependent kinase-like 5 in synaptic morphogenesis. Pharmaceutical targets and the potential use of Netrin G1/NGL-1 as treatment targets or biomarkers for SCZ were also discussed.https://journals.lww.com/10.4103/tcmj.tcmj_83_24microglianetrin g1/netrin-g-ligand-1schizophreniasynaptic plasticity |
| spellingShingle | Ayooluwa Gabriel Ibiayo Luo-Zhu Yang Ingrid Y. Liu The role of netrin G1-netrin-G-ligand-1 in schizophrenia Tzu Chi Medical Journal microglia netrin g1/netrin-g-ligand-1 schizophrenia synaptic plasticity |
| title | The role of netrin G1-netrin-G-ligand-1 in schizophrenia |
| title_full | The role of netrin G1-netrin-G-ligand-1 in schizophrenia |
| title_fullStr | The role of netrin G1-netrin-G-ligand-1 in schizophrenia |
| title_full_unstemmed | The role of netrin G1-netrin-G-ligand-1 in schizophrenia |
| title_short | The role of netrin G1-netrin-G-ligand-1 in schizophrenia |
| title_sort | role of netrin g1 netrin g ligand 1 in schizophrenia |
| topic | microglia netrin g1/netrin-g-ligand-1 schizophrenia synaptic plasticity |
| url | https://journals.lww.com/10.4103/tcmj.tcmj_83_24 |
| work_keys_str_mv | AT ayooluwagabrielibiayo theroleofnetring1netringligand1inschizophrenia AT luozhuyang theroleofnetring1netringligand1inschizophrenia AT ingridyliu theroleofnetring1netringligand1inschizophrenia AT ayooluwagabrielibiayo roleofnetring1netringligand1inschizophrenia AT luozhuyang roleofnetring1netringligand1inschizophrenia AT ingridyliu roleofnetring1netringligand1inschizophrenia |