Effects of subclinical hypothyroidism during pregnancy on mtDNA methylation in the brain of rat offspring

Effects of subclinical hypothyroidism during pregnancy on mtDNA methylation in the brain of rat offspring

Abstract Objective This study aims to investigate the impact of subclinical hypothyroidism (SCH) during pregnancy on mitochondrial DNA (mtDNA) methylation in the brain tissues of rat offspring. Materials and methods Sixteen SD rats were randomly divided into two groups: control group (CON) and SCH g...

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Bibliographic Details
Main Authors: Liangzhuo Xie, Yangling Huang, Xiande Ma, Xiaoqiu Ma, Jian Wang, Tianshu Gao, Wei Chen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Neuroscience
Subjects:
Subclinical hypothyroidism
Offspring
mtDNA
Methylation
Brain tissue
Online Access:https://doi.org/10.1186/s12868-025-00930-2
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