Association of sarcopenia and physical activity on the severity of metabolic dysfunction-associated steatotic liver disease among United States adults: NHANES 2017 - 2018
BackgroundSarcopenia, physical activity (PA), and sedentary behavior are associated with metabolic dysfunction-associated steatotic liver disease (MASLD). The study aimed to evaluate the effects of sarcopenia and PA on the presence and severity of MASLD.MethodsThis cross-sectional study analyzed dat...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Aging |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2025.1573170/full |
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| author | Xiaodie Wei Xiaohui Liu Jinhan Zhao Jinhan Zhao Yang Zhang Lixia Qiu Jing Zhang |
| author_facet | Xiaodie Wei Xiaohui Liu Jinhan Zhao Jinhan Zhao Yang Zhang Lixia Qiu Jing Zhang |
| author_sort | Xiaodie Wei |
| collection | DOAJ |
| description | BackgroundSarcopenia, physical activity (PA), and sedentary behavior are associated with metabolic dysfunction-associated steatotic liver disease (MASLD). The study aimed to evaluate the effects of sarcopenia and PA on the presence and severity of MASLD.MethodsThis cross-sectional study analyzed data from the 2017-2018 National Health and Nutrition Examination Survey (NHANES). Hepatic steatosis and liver fibrosis were assessed by vibration-controlled transient elastography (VCTE). Sarcopenia was defined based on the Foundation for the National Institutes of Health criteria. PA and sedentary behavior were evaluated using the Global Physical Activity Questionnaire (GPAQ).ResultsAmong 1,831 participants, 664 were diagnosed with MASLD, including 482 with severe steatosis and 89 with significant fibrosis. The prevalence of sarcopenia in the MASLD and non-MASLD populations was 11.7% and 3.8%, respectively. Multivariable-adjusted models demonstrated that sarcopenia significantly increased the risk of MASLD (OR 2.45; 95% CI: 1.33–4.52), severe steatosis (OR 2.56; 95% CI: 1.40–4.66), and significant fibrosis (OR 6.10; 95% CI: 2.08–17.84). Additionally, individuals with sarcopenia and low PA had a 7.91-fold increased risk of developing significant fibrosis (OR, 7.91; 95% CI: 1.42–44.16, P = 0.022). Sarcopenia and prolonged sedentary behavior further increased the risk of MASLD (OR 3.75; 95% CI: 1.60–8.76), severe steatosis (OR 17.58; 95% CI: 1.93–159.79), and significant fibrosis (OR 4.32; 95% CI: 1.31–14.31).ConclusionPatients with sarcopenia should increase physical activity and reduce sedentary time to decrease the risk and progression of MASLD. Increasing muscle mass and strength through resistance exercise to reduce the risk of significant fibrosis in sarcopenia patients. |
| format | Article |
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| institution | OA Journals |
| issn | 2673-6217 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging |
| spelling | doaj-art-d8cf9f324e7d4353a25fe854acea197c2025-08-20T01:50:23ZengFrontiers Media S.A.Frontiers in Aging2673-62172025-05-01610.3389/fragi.2025.15731701573170Association of sarcopenia and physical activity on the severity of metabolic dysfunction-associated steatotic liver disease among United States adults: NHANES 2017 - 2018Xiaodie Wei0Xiaohui Liu1Jinhan Zhao2Jinhan Zhao3Yang Zhang4Lixia Qiu5Jing Zhang6The Third Unit, The Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaThe Third Unit, The Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaThe Third Unit, The Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaThe Third Unit, The Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaThe Third Unit, The Department of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBackgroundSarcopenia, physical activity (PA), and sedentary behavior are associated with metabolic dysfunction-associated steatotic liver disease (MASLD). The study aimed to evaluate the effects of sarcopenia and PA on the presence and severity of MASLD.MethodsThis cross-sectional study analyzed data from the 2017-2018 National Health and Nutrition Examination Survey (NHANES). Hepatic steatosis and liver fibrosis were assessed by vibration-controlled transient elastography (VCTE). Sarcopenia was defined based on the Foundation for the National Institutes of Health criteria. PA and sedentary behavior were evaluated using the Global Physical Activity Questionnaire (GPAQ).ResultsAmong 1,831 participants, 664 were diagnosed with MASLD, including 482 with severe steatosis and 89 with significant fibrosis. The prevalence of sarcopenia in the MASLD and non-MASLD populations was 11.7% and 3.8%, respectively. Multivariable-adjusted models demonstrated that sarcopenia significantly increased the risk of MASLD (OR 2.45; 95% CI: 1.33–4.52), severe steatosis (OR 2.56; 95% CI: 1.40–4.66), and significant fibrosis (OR 6.10; 95% CI: 2.08–17.84). Additionally, individuals with sarcopenia and low PA had a 7.91-fold increased risk of developing significant fibrosis (OR, 7.91; 95% CI: 1.42–44.16, P = 0.022). Sarcopenia and prolonged sedentary behavior further increased the risk of MASLD (OR 3.75; 95% CI: 1.60–8.76), severe steatosis (OR 17.58; 95% CI: 1.93–159.79), and significant fibrosis (OR 4.32; 95% CI: 1.31–14.31).ConclusionPatients with sarcopenia should increase physical activity and reduce sedentary time to decrease the risk and progression of MASLD. Increasing muscle mass and strength through resistance exercise to reduce the risk of significant fibrosis in sarcopenia patients.https://www.frontiersin.org/articles/10.3389/fragi.2025.1573170/fullmetabolic dysfunction-associated steatotic liver diseasephysical activitysarcopeniaNHANESliver fibrosis |
| spellingShingle | Xiaodie Wei Xiaohui Liu Jinhan Zhao Jinhan Zhao Yang Zhang Lixia Qiu Jing Zhang Association of sarcopenia and physical activity on the severity of metabolic dysfunction-associated steatotic liver disease among United States adults: NHANES 2017 - 2018 Frontiers in Aging metabolic dysfunction-associated steatotic liver disease physical activity sarcopenia NHANES liver fibrosis |
| title | Association of sarcopenia and physical activity on the severity of metabolic dysfunction-associated steatotic liver disease among United States adults: NHANES 2017 - 2018 |
| title_full | Association of sarcopenia and physical activity on the severity of metabolic dysfunction-associated steatotic liver disease among United States adults: NHANES 2017 - 2018 |
| title_fullStr | Association of sarcopenia and physical activity on the severity of metabolic dysfunction-associated steatotic liver disease among United States adults: NHANES 2017 - 2018 |
| title_full_unstemmed | Association of sarcopenia and physical activity on the severity of metabolic dysfunction-associated steatotic liver disease among United States adults: NHANES 2017 - 2018 |
| title_short | Association of sarcopenia and physical activity on the severity of metabolic dysfunction-associated steatotic liver disease among United States adults: NHANES 2017 - 2018 |
| title_sort | association of sarcopenia and physical activity on the severity of metabolic dysfunction associated steatotic liver disease among united states adults nhanes 2017 2018 |
| topic | metabolic dysfunction-associated steatotic liver disease physical activity sarcopenia NHANES liver fibrosis |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2025.1573170/full |
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