CGT 4.0: a distant dream or inevitable future? Smart process automation is critical to make efficient scalability of CGT manufacturing a reality

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Main Authors: Aleksander Szarzynski, Oliver Spadiut, Matthias Reisbeck, Gerhard Jobst, Rachel L. Paterson, Anna Kamenskaya, Emilie Gateau, Hanna P. Lesch, Luc Henry, Bence Kozma
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Bioengineering and Biotechnology
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Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1563878/full
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author Aleksander Szarzynski
Oliver Spadiut
Matthias Reisbeck
Gerhard Jobst
Rachel L. Paterson
Anna Kamenskaya
Emilie Gateau
Hanna P. Lesch
Luc Henry
Bence Kozma
author_facet Aleksander Szarzynski
Oliver Spadiut
Matthias Reisbeck
Gerhard Jobst
Rachel L. Paterson
Anna Kamenskaya
Emilie Gateau
Hanna P. Lesch
Luc Henry
Bence Kozma
author_sort Aleksander Szarzynski
collection DOAJ
format Article
id doaj-art-d8c2e4675d134ee3967d0ad456ec2a8e
institution DOAJ
issn 2296-4185
language English
publishDate 2025-03-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Bioengineering and Biotechnology
spelling doaj-art-d8c2e4675d134ee3967d0ad456ec2a8e2025-08-20T03:02:47ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-03-011310.3389/fbioe.2025.15638781563878CGT 4.0: a distant dream or inevitable future? Smart process automation is critical to make efficient scalability of CGT manufacturing a realityAleksander Szarzynski0Oliver Spadiut1Matthias Reisbeck2Gerhard Jobst3Rachel L. Paterson4Anna Kamenskaya5Emilie Gateau6Hanna P. Lesch7Luc Henry8Bence Kozma9Research Unit of Biochemical Engineering, Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, AustriaResearch Unit of Biochemical Engineering, Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, AustriaJobst Technologies GmbH, Freiburg, GermanyJobst Technologies GmbH, Freiburg, GermanyStemmatters Biotecnologia e Medicina Regenerativa SA, Guimarães, PortugalDa Vinci Labs SAS, Tours, FranceExothera SA, Jumet, BelgiumExothera SA, Jumet, BelgiumLimula SA, Épalinges, SwitzerlandResearch Unit of Biochemical Engineering, Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austriahttps://www.frontiersin.org/articles/10.3389/fbioe.2025.1563878/fullcell and gene therapyautomationsensorsPATsingle-usedigital twin
spellingShingle Aleksander Szarzynski
Oliver Spadiut
Matthias Reisbeck
Gerhard Jobst
Rachel L. Paterson
Anna Kamenskaya
Emilie Gateau
Hanna P. Lesch
Luc Henry
Bence Kozma
CGT 4.0: a distant dream or inevitable future? Smart process automation is critical to make efficient scalability of CGT manufacturing a reality
Frontiers in Bioengineering and Biotechnology
cell and gene therapy
automation
sensors
PAT
single-use
digital twin
title CGT 4.0: a distant dream or inevitable future? Smart process automation is critical to make efficient scalability of CGT manufacturing a reality
title_full CGT 4.0: a distant dream or inevitable future? Smart process automation is critical to make efficient scalability of CGT manufacturing a reality
title_fullStr CGT 4.0: a distant dream or inevitable future? Smart process automation is critical to make efficient scalability of CGT manufacturing a reality
title_full_unstemmed CGT 4.0: a distant dream or inevitable future? Smart process automation is critical to make efficient scalability of CGT manufacturing a reality
title_short CGT 4.0: a distant dream or inevitable future? Smart process automation is critical to make efficient scalability of CGT manufacturing a reality
title_sort cgt 4 0 a distant dream or inevitable future smart process automation is critical to make efficient scalability of cgt manufacturing a reality
topic cell and gene therapy
automation
sensors
PAT
single-use
digital twin
url https://www.frontiersin.org/articles/10.3389/fbioe.2025.1563878/full
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