Posttransplant Hyponatremia Predicts Graft Failure and Mortality in Kidney Transplantation Recipients: A Multicenter Cohort Study in Korea.
Although hyponatremia is related to poorer outcomes in several clinical settings, its significance remains unresolved in kidney transplantation. Data on 1,786 patients who received kidney transplantations between January 2000 and December 2011 were analyzed. The patients were divided into two groups...
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Public Library of Science (PLoS)
2016-01-01
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| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0156050&type=printable |
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| author | Seung Seok Han Miyeun Han Jae Yoon Park Jung Nam An Seokwoo Park Su-Kil Park Duck-Jong Han Ki Young Na Yun Kyu Oh Chun Soo Lim Yon Su Kim Young Hoon Kim Jung Pyo Lee |
| author_facet | Seung Seok Han Miyeun Han Jae Yoon Park Jung Nam An Seokwoo Park Su-Kil Park Duck-Jong Han Ki Young Na Yun Kyu Oh Chun Soo Lim Yon Su Kim Young Hoon Kim Jung Pyo Lee |
| author_sort | Seung Seok Han |
| collection | DOAJ |
| description | Although hyponatremia is related to poorer outcomes in several clinical settings, its significance remains unresolved in kidney transplantation. Data on 1,786 patients who received kidney transplantations between January 2000 and December 2011 were analyzed. The patients were divided into two groups according to the corrected sodium values for serum glucose 3 months after their transplantations (<135 mmol/L vs. ≥135 mmol/L). Subsequently, the hazard ratios (HRs) for biopsy-proven acute rejection, graft failure, and all-cause mortality were calculated after adjustments for several immunological and non-immunological covariates. 4.0% of patients had hyponatremia. Patients with hyponatremia had higher risks for graft failure and all-cause mortality than did the counterpart normonatremia group; the adjusted HRs for graft failure and mortality were 3.21 (1.47-6.99) and 3.03 (1.21-7.54), respectively. These relationships remained consistent irrespective of heart function. However, hyponatremia was not associated with the risk of acute rejection. The present study addressed the association between hyponatremia and graft and patient outcomes in kidney transplant recipients. Based on the study results, our recommendation is to monitor serum sodium levels after kidney transplantations. |
| format | Article |
| id | doaj-art-d8bffdaf67e64d7091e39c5c0f901c07 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-d8bffdaf67e64d7091e39c5c0f901c072025-08-20T03:10:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01115e015605010.1371/journal.pone.0156050Posttransplant Hyponatremia Predicts Graft Failure and Mortality in Kidney Transplantation Recipients: A Multicenter Cohort Study in Korea.Seung Seok HanMiyeun HanJae Yoon ParkJung Nam AnSeokwoo ParkSu-Kil ParkDuck-Jong HanKi Young NaYun Kyu OhChun Soo LimYon Su KimYoung Hoon KimJung Pyo LeeAlthough hyponatremia is related to poorer outcomes in several clinical settings, its significance remains unresolved in kidney transplantation. Data on 1,786 patients who received kidney transplantations between January 2000 and December 2011 were analyzed. The patients were divided into two groups according to the corrected sodium values for serum glucose 3 months after their transplantations (<135 mmol/L vs. ≥135 mmol/L). Subsequently, the hazard ratios (HRs) for biopsy-proven acute rejection, graft failure, and all-cause mortality were calculated after adjustments for several immunological and non-immunological covariates. 4.0% of patients had hyponatremia. Patients with hyponatremia had higher risks for graft failure and all-cause mortality than did the counterpart normonatremia group; the adjusted HRs for graft failure and mortality were 3.21 (1.47-6.99) and 3.03 (1.21-7.54), respectively. These relationships remained consistent irrespective of heart function. However, hyponatremia was not associated with the risk of acute rejection. The present study addressed the association between hyponatremia and graft and patient outcomes in kidney transplant recipients. Based on the study results, our recommendation is to monitor serum sodium levels after kidney transplantations.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0156050&type=printable |
| spellingShingle | Seung Seok Han Miyeun Han Jae Yoon Park Jung Nam An Seokwoo Park Su-Kil Park Duck-Jong Han Ki Young Na Yun Kyu Oh Chun Soo Lim Yon Su Kim Young Hoon Kim Jung Pyo Lee Posttransplant Hyponatremia Predicts Graft Failure and Mortality in Kidney Transplantation Recipients: A Multicenter Cohort Study in Korea. PLoS ONE |
| title | Posttransplant Hyponatremia Predicts Graft Failure and Mortality in Kidney Transplantation Recipients: A Multicenter Cohort Study in Korea. |
| title_full | Posttransplant Hyponatremia Predicts Graft Failure and Mortality in Kidney Transplantation Recipients: A Multicenter Cohort Study in Korea. |
| title_fullStr | Posttransplant Hyponatremia Predicts Graft Failure and Mortality in Kidney Transplantation Recipients: A Multicenter Cohort Study in Korea. |
| title_full_unstemmed | Posttransplant Hyponatremia Predicts Graft Failure and Mortality in Kidney Transplantation Recipients: A Multicenter Cohort Study in Korea. |
| title_short | Posttransplant Hyponatremia Predicts Graft Failure and Mortality in Kidney Transplantation Recipients: A Multicenter Cohort Study in Korea. |
| title_sort | posttransplant hyponatremia predicts graft failure and mortality in kidney transplantation recipients a multicenter cohort study in korea |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0156050&type=printable |
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