Effect of myo-inositol and d-chiro-inositol on improving hormonal, metabolic and reproductive parameters in women with polycystic ovary syndrome: A review of studies
Polycystic ovary syndrome (PCOS) is a leading cause of anovulatory infertility, affecting 6–12% of women of reproductive age. It is characterized by hormonal and metabolic disturbances, including insulin resistance, hyperandrogenism, and dyslipidemia, which significantly impair reproductive function...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-05-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/60350 |
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| author | Aleksandra Ciuła Michał Borawski Anna Jakubiak Joanna Miśkiewicz Tadeusz Kuźnieców grzegorz Karaban Patrycja Znamirowska Klaudia Mularczyk Magdalena Kupis Monika Paszkowska |
| author_facet | Aleksandra Ciuła Michał Borawski Anna Jakubiak Joanna Miśkiewicz Tadeusz Kuźnieców grzegorz Karaban Patrycja Znamirowska Klaudia Mularczyk Magdalena Kupis Monika Paszkowska |
| author_sort | Aleksandra Ciuła |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) is a leading cause of anovulatory infertility, affecting 6–12% of women of reproductive age. It is characterized by hormonal and metabolic disturbances, including insulin resistance, hyperandrogenism, and dyslipidemia, which significantly impair reproductive function and overall health. Effective management of PCOS requires a multifactorial approach combining pharmacotherapy, dietary intervention, and physical activity. This literature review aims to evaluate the therapeutic potential of inositol, particularly myo-inositol (MI), in the treatment of PCOS, with a focus on its impact on metabolic, hormonal, and reproductive parameters. Scientific articles published within the last 10 years were selected from PubMed and Google Scholar using specific keywords related to inositol supplementation in PCOS. The analysis demonstrates that MI supplementation improves insulin sensitivity, lowers androgen levels, enhances follicular development, and improves oocyte quality. Furthermore, combination therapy with MI and metformin yields superior outcomes compared to monotherapy, including improved menstrual regularity, reduced hyperandrogenic symptoms, and increased conception rates. Evidence also suggests enhanced outcomes in assisted reproductive technologies, such as in vitro fertilization (IVF), following MI use. The combined application of MI, D-chiro-inositol, metformin, and lifestyle modifications appears to exert a synergistic effect, optimizing hormonal balance and fertility, while also mitigating long-term metabolic and cardiovascular risks in women with PCOS.
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| format | Article |
| id | doaj-art-d8bf8fa89d944be78613ae783ed84d81 |
| institution | OA Journals |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-d8bf8fa89d944be78613ae783ed84d812025-08-20T02:15:32ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-05-014110.12775/QS.2025.41.60350Effect of myo-inositol and d-chiro-inositol on improving hormonal, metabolic and reproductive parameters in women with polycystic ovary syndrome: A review of studiesAleksandra Ciuła0https://orcid.org/0009-0000-0425-863XMichał Borawski1https://orcid.org/0009-0008-4864-7336Anna Jakubiak2https://orcid.org/0009-0004-0973-7591Joanna Miśkiewicz3https://orcid.org/0009-0002-3300-940XTadeusz Kuźnieców4https://orcid.org/0009-0000-2120-9549grzegorz Karaban5https://orcid.org/0009-0001-9285-469XPatrycja Znamirowska6https://orcid.org/0009-0002-7538-5315Klaudia Mularczyk7https://orcid.org/0009-0008-3250-7806Magdalena Kupis8https://orcid.org/0009-0009-4454-5866Monika Paszkowska9https://orcid.org/0009-0009-2006-0098Brothers Hospitallers of Saint John of God Hospital in Cracow Trynitarska 11, 31-061 Cracow, PolandBrothers Hospitallers of Saint John of God Hospital in Cracow Trynitarska 11, 31-061 Cracow, PolandNational Medical Institute of the Ministry of the Interior and Administration Wołoska 137, 02-507 Warsaw, PolandProvincial Hospital in Kielce Grunwaldzka 45, 25-736 Kielce, PolandMiędzylesie Specialist Hospital in Warsaw, Bursztynowa 2, 04-749 Warsaw, PolandMiędzylesie Specialist Hospital in Warsaw Bursztynowa 2, 04-749 Warsaw, PolandSpecialist Hospital Dr. Tytus Chałubiński in Radom Lekarska 4, 26-610 Radom, PolandMiędzylesie Specialist Hospital in Warsaw Bursztynowa 2, 04-749 Warsaw, PolandCasimir Pulaski University of Radom, Faculty of Medical Sciences and Health SciencesMiędzylesie Specialist Hospital in Warsaw Bursztynowa 2, 04-749 Warsaw, PolandPolycystic ovary syndrome (PCOS) is a leading cause of anovulatory infertility, affecting 6–12% of women of reproductive age. It is characterized by hormonal and metabolic disturbances, including insulin resistance, hyperandrogenism, and dyslipidemia, which significantly impair reproductive function and overall health. Effective management of PCOS requires a multifactorial approach combining pharmacotherapy, dietary intervention, and physical activity. This literature review aims to evaluate the therapeutic potential of inositol, particularly myo-inositol (MI), in the treatment of PCOS, with a focus on its impact on metabolic, hormonal, and reproductive parameters. Scientific articles published within the last 10 years were selected from PubMed and Google Scholar using specific keywords related to inositol supplementation in PCOS. The analysis demonstrates that MI supplementation improves insulin sensitivity, lowers androgen levels, enhances follicular development, and improves oocyte quality. Furthermore, combination therapy with MI and metformin yields superior outcomes compared to monotherapy, including improved menstrual regularity, reduced hyperandrogenic symptoms, and increased conception rates. Evidence also suggests enhanced outcomes in assisted reproductive technologies, such as in vitro fertilization (IVF), following MI use. The combined application of MI, D-chiro-inositol, metformin, and lifestyle modifications appears to exert a synergistic effect, optimizing hormonal balance and fertility, while also mitigating long-term metabolic and cardiovascular risks in women with PCOS. https://apcz.umk.pl/QS/article/view/60350inositolmyo-inositold-chiro-inositolpolycystic ovary syndromeinsulin resistance |
| spellingShingle | Aleksandra Ciuła Michał Borawski Anna Jakubiak Joanna Miśkiewicz Tadeusz Kuźnieców grzegorz Karaban Patrycja Znamirowska Klaudia Mularczyk Magdalena Kupis Monika Paszkowska Effect of myo-inositol and d-chiro-inositol on improving hormonal, metabolic and reproductive parameters in women with polycystic ovary syndrome: A review of studies Quality in Sport inositol myo-inositol d-chiro-inositol polycystic ovary syndrome insulin resistance |
| title | Effect of myo-inositol and d-chiro-inositol on improving hormonal, metabolic and reproductive parameters in women with polycystic ovary syndrome: A review of studies |
| title_full | Effect of myo-inositol and d-chiro-inositol on improving hormonal, metabolic and reproductive parameters in women with polycystic ovary syndrome: A review of studies |
| title_fullStr | Effect of myo-inositol and d-chiro-inositol on improving hormonal, metabolic and reproductive parameters in women with polycystic ovary syndrome: A review of studies |
| title_full_unstemmed | Effect of myo-inositol and d-chiro-inositol on improving hormonal, metabolic and reproductive parameters in women with polycystic ovary syndrome: A review of studies |
| title_short | Effect of myo-inositol and d-chiro-inositol on improving hormonal, metabolic and reproductive parameters in women with polycystic ovary syndrome: A review of studies |
| title_sort | effect of myo inositol and d chiro inositol on improving hormonal metabolic and reproductive parameters in women with polycystic ovary syndrome a review of studies |
| topic | inositol myo-inositol d-chiro-inositol polycystic ovary syndrome insulin resistance |
| url | https://apcz.umk.pl/QS/article/view/60350 |
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