HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular Signaling
The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus associated with both proliferative and inflammatory disorders. This virus causes a persistent infection, mainly in CD4+ T lymphocyte. The ability to persist in the host is associated with the virus capacity to evade the immune respo...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/498054 |
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| author | Carolina Rosadas Marzia Puccioni-Sohler |
| author_facet | Carolina Rosadas Marzia Puccioni-Sohler |
| author_sort | Carolina Rosadas |
| collection | DOAJ |
| description | The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus associated with both proliferative and inflammatory disorders. This virus causes a persistent infection, mainly in CD4+ T lymphocyte. The ability to persist in the host is associated with the virus capacity to evade the immune response and to induce infected T-cell proliferation, once the HTLV-1 maintains the infection mainly by clonal expansion of infected cells. There are several evidences that ORF-I encoded proteins, such as p12 and p8, play an important role in this context. The present study will review the molecular mechanisms that HTLV-1 ORF-I encoded proteins have to induce dysregulation of intracellular signaling, in order to escape from immune response and to increase the infected T-cell proliferation rate. The work will also address the impact of ORF-I mutations on the human
host and perspectives in this study field. |
| format | Article |
| id | doaj-art-d8bf7db024c04bf283b9dbf5ba927b12 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-d8bf7db024c04bf283b9dbf5ba927b122025-08-20T03:24:16ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/498054498054HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular SignalingCarolina Rosadas0Marzia Puccioni-Sohler1Universidade Federal do Rio de Janeiro (UFRJ), Rua Rodolpho Paulo Rocco 255, 3° Andar, Cidade Universitária, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, BrazilUniversidade Federal do Rio de Janeiro (UFRJ), Rua Rodolpho Paulo Rocco 255, 3° Andar, Cidade Universitária, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, BrazilThe human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus associated with both proliferative and inflammatory disorders. This virus causes a persistent infection, mainly in CD4+ T lymphocyte. The ability to persist in the host is associated with the virus capacity to evade the immune response and to induce infected T-cell proliferation, once the HTLV-1 maintains the infection mainly by clonal expansion of infected cells. There are several evidences that ORF-I encoded proteins, such as p12 and p8, play an important role in this context. The present study will review the molecular mechanisms that HTLV-1 ORF-I encoded proteins have to induce dysregulation of intracellular signaling, in order to escape from immune response and to increase the infected T-cell proliferation rate. The work will also address the impact of ORF-I mutations on the human host and perspectives in this study field.http://dx.doi.org/10.1155/2015/498054 |
| spellingShingle | Carolina Rosadas Marzia Puccioni-Sohler HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular Signaling Journal of Immunology Research |
| title | HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular Signaling |
| title_full | HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular Signaling |
| title_fullStr | HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular Signaling |
| title_full_unstemmed | HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular Signaling |
| title_short | HTLV-1 ORF-I Encoded Proteins and the Regulation of Host Immune Response: Viral Induced Dysregulation of Intracellular Signaling |
| title_sort | htlv 1 orf i encoded proteins and the regulation of host immune response viral induced dysregulation of intracellular signaling |
| url | http://dx.doi.org/10.1155/2015/498054 |
| work_keys_str_mv | AT carolinarosadas htlv1orfiencodedproteinsandtheregulationofhostimmuneresponseviralinduceddysregulationofintracellularsignaling AT marziapuccionisohler htlv1orfiencodedproteinsandtheregulationofhostimmuneresponseviralinduceddysregulationofintracellularsignaling |