Investigating the analgesic effects of combined diphenhydramine and dipyrone in mice
Pain relief is a crucial aspect of modern surgery. The analgesic used should possess strong analgesic properties, a rapid onset of action, and minimal side effects to effectively reduce pain during and after surgical procedures. Therefore, the aim of the present study was to evaluate the analgesic e...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahid Bahonar University of Kerman
2024-08-01
|
| Series: | Veterinary and Comparative Biomedical Research |
| Subjects: | |
| Online Access: | https://vcbr.uk.ac.ir/article_4405_2f86f5c445e3a4a3bade497443d6e865.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850188838569246720 |
|---|---|
| author | Mostafa Kalantari Firouz Faedmaleki Arya Soneishargh |
| author_facet | Mostafa Kalantari Firouz Faedmaleki Arya Soneishargh |
| author_sort | Mostafa Kalantari |
| collection | DOAJ |
| description | Pain relief is a crucial aspect of modern surgery. The analgesic used should possess strong analgesic properties, a rapid onset of action, and minimal side effects to effectively reduce pain during and after surgical procedures. Therefore, the aim of the present study was to evaluate the analgesic effects of diphenhydramine and dipyrone (metamizole) in mice. For this study, 30 mice were randomly divided into five groups: the control group received normal saline; the standard group received 10 mg/kg morphine; treatment group 1 received 2.5 mg/kg diphenhydramine; treatment group 2 received 2.5 mg/kg dipyrone; and treatment group 3 received 2.5 mg/kg diphenhydramine combined with 2.5 mg/kg dipyrone. After injection, pain was assessed using the hot plate test and the formalin test. The results from both tests indicated that the combined use of dipyrone and diphenhydramine produced significant analgesic effects. Additionally, neither dipyrone (metamizole) nor diphenhydramine exhibited any side effects. Therefore, the use of dipyrone (metamizole) and diphenhydramine is recommended for safer surgical procedures. |
| format | Article |
| id | doaj-art-d8be7f656ddd4c668d0388c84b119eba |
| institution | OA Journals |
| issn | 3060-7663 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Shahid Bahonar University of Kerman |
| record_format | Article |
| series | Veterinary and Comparative Biomedical Research |
| spelling | doaj-art-d8be7f656ddd4c668d0388c84b119eba2025-08-20T02:15:46ZengShahid Bahonar University of KermanVeterinary and Comparative Biomedical Research3060-76632024-08-0112667110.22103/vcbr.2024.23833.10244405Investigating the analgesic effects of combined diphenhydramine and dipyrone in miceMostafa Kalantari0Firouz Faedmaleki1Arya Soneishargh2Graduated from the Faculty of Veterinary Medicine, Babol branch, Islamic Azad University, Babol, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, Babol branch, Islamic Azad University, Babol, IranGraduated from the Faculty of Sciences, Neyshabour branch, Islamic Azad University, Neyshabour, IranPain relief is a crucial aspect of modern surgery. The analgesic used should possess strong analgesic properties, a rapid onset of action, and minimal side effects to effectively reduce pain during and after surgical procedures. Therefore, the aim of the present study was to evaluate the analgesic effects of diphenhydramine and dipyrone (metamizole) in mice. For this study, 30 mice were randomly divided into five groups: the control group received normal saline; the standard group received 10 mg/kg morphine; treatment group 1 received 2.5 mg/kg diphenhydramine; treatment group 2 received 2.5 mg/kg dipyrone; and treatment group 3 received 2.5 mg/kg diphenhydramine combined with 2.5 mg/kg dipyrone. After injection, pain was assessed using the hot plate test and the formalin test. The results from both tests indicated that the combined use of dipyrone and diphenhydramine produced significant analgesic effects. Additionally, neither dipyrone (metamizole) nor diphenhydramine exhibited any side effects. Therefore, the use of dipyrone (metamizole) and diphenhydramine is recommended for safer surgical procedures.https://vcbr.uk.ac.ir/article_4405_2f86f5c445e3a4a3bade497443d6e865.pdfanalgesiadiphenhydraminedipyronepain |
| spellingShingle | Mostafa Kalantari Firouz Faedmaleki Arya Soneishargh Investigating the analgesic effects of combined diphenhydramine and dipyrone in mice Veterinary and Comparative Biomedical Research analgesia diphenhydramine dipyrone pain |
| title | Investigating the analgesic effects of combined diphenhydramine and dipyrone in mice |
| title_full | Investigating the analgesic effects of combined diphenhydramine and dipyrone in mice |
| title_fullStr | Investigating the analgesic effects of combined diphenhydramine and dipyrone in mice |
| title_full_unstemmed | Investigating the analgesic effects of combined diphenhydramine and dipyrone in mice |
| title_short | Investigating the analgesic effects of combined diphenhydramine and dipyrone in mice |
| title_sort | investigating the analgesic effects of combined diphenhydramine and dipyrone in mice |
| topic | analgesia diphenhydramine dipyrone pain |
| url | https://vcbr.uk.ac.ir/article_4405_2f86f5c445e3a4a3bade497443d6e865.pdf |
| work_keys_str_mv | AT mostafakalantari investigatingtheanalgesiceffectsofcombineddiphenhydramineanddipyroneinmice AT firouzfaedmaleki investigatingtheanalgesiceffectsofcombineddiphenhydramineanddipyroneinmice AT aryasoneishargh investigatingtheanalgesiceffectsofcombineddiphenhydramineanddipyroneinmice |