Caerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME-mediated pyroptosis in epithelial cancer cells

Caerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME-mediated pyroptosis in epithelial cancer cells

Abstract Caerin peptides exhibit a dual role in cancer treatment by directly killing cancer cells and modulating the tumour microenvironment to enhance anti-tumour immunity. This study investigates the mechanisms underlying caerin 1.1/1.9-induced acute cell death in epithelial cancer cells and explo...

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Main Authors: Yuandong Luo, Junjie Li, Quanlan Fu, Pingping Zhang, Xinyi Song, Mengqi Liu, Rongmi Mo, Jiawei Fu, Shuxian Tang, Jialing Wu, Xiaodan Yang, Xiaosong Liu, Tianfang Wang, Guoying Ni
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Caerin peptide
Pyroptosis
Caspase 3/GSDME signalling pathway
IL-18
Lactate dehydrogenase
Online Access:https://doi.org/10.1038/s41598-025-96438-0
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