Computational revealing Infigratinib resistance to the FGFR2 N549H and N549K mutations

Fibroblast growth factor receptor 2 (FGFR2) is a receptor tyrosine kinase that is involved in many human cancers such as intrahepatic cholangiocarcinomas and hepatocellular carcinomas. The clinically acquired FGFR2 N549H/K mutations make the treatment of Infigratinib ineffective. Here, molecular doc...

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Bibliographic Details
Main Authors: Guanghuan Xu, Bin Wu, Wenqi Liang, Jingfeng Zhang, Shenqian Xu, Tingting Du, Minyu Li, Guodong Zheng, Bin Zhou, Zhiping Wang, Wuxia Liu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Experimental Nanoscience
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Online Access:https://www.tandfonline.com/doi/10.1080/17458080.2024.2442305
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