Evaluation of Bleb Morphology and Reduction in IOP and Glaucoma Medication following Implantation of a Novel Gel Stent
Objective. To evaluate the efficacy and safety of the Xen Gel Stent and provide a macro- and microscopic analyses of bleb morphology. Methods. A prospective 12-month study on patients with primary open-angle glaucoma. Patients underwent implantation of the XEN Gel Stent (Allergan INC, Dublin, Irelan...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/9364910 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850166816459980800 |
|---|---|
| author | Antonio Maria Fea Roberta Spinetta Paola Maria Loredana Cannizzo Giulia Consolandi Carlo Lavia Vittoria Aragno Francesco Germinetti Teresa Rolle |
| author_facet | Antonio Maria Fea Roberta Spinetta Paola Maria Loredana Cannizzo Giulia Consolandi Carlo Lavia Vittoria Aragno Francesco Germinetti Teresa Rolle |
| author_sort | Antonio Maria Fea |
| collection | DOAJ |
| description | Objective. To evaluate the efficacy and safety of the Xen Gel Stent and provide a macro- and microscopic analyses of bleb morphology. Methods. A prospective 12-month study on patients with primary open-angle glaucoma. Patients underwent implantation of the XEN Gel Stent (Allergan INC, Dublin, Ireland) either alone or combined with a cataract surgery. Biomicroscopy, in vivo confocal microscopy (IVCM), and anterior segment-optical coherence tomography (AS-OCT) were used to assess bleb morphology. Safety parameters were adverse events, best corrected visual acuity, visual field, and corneal endothelial cell loss. A postoperative IOP ≤ 18 mmHg without or on medications was respectively defined as complete and qualified success while an IOP ≥ 18 mmHg was defined as failure. Results. Twelve eyes of 11 patients were evaluated. At one year, 5 out of 10 patients available achieved a complete success while five were qualified success. AS-OCT showed that bleb wall reflectivity was significantly higher in the failure group; IVCM revealed that stromal density was significantly lower in the success group. No safety issues were recorded. Conclusion. Implantation of the XEN Gel Stent appears to be a safe and effective procedure. AS-OCT and IVCM may be helpful in bleb assessment. |
| format | Article |
| id | doaj-art-d8b9226283564768aa77adf9e92a8465 |
| institution | OA Journals |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-d8b9226283564768aa77adf9e92a84652025-08-20T02:21:20ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/93649109364910Evaluation of Bleb Morphology and Reduction in IOP and Glaucoma Medication following Implantation of a Novel Gel StentAntonio Maria Fea0Roberta Spinetta1Paola Maria Loredana Cannizzo2Giulia Consolandi3Carlo Lavia4Vittoria Aragno5Francesco Germinetti6Teresa Rolle7Clinica Oculistica, Dipartimento di Scienze Chirugiche, Universita' di Torino, Via Juvarra 19, 10100 Torino, ItalyClinica Oculistica, Dipartimento di Scienze Chirugiche, Universita' di Torino, Via Juvarra 19, 10100 Torino, ItalyClinica Oculistica, Dipartimento di Scienze Chirugiche, Universita' di Torino, Via Juvarra 19, 10100 Torino, ItalyClinica Oculistica, Dipartimento di Scienze Chirugiche, Universita' di Torino, Via Juvarra 19, 10100 Torino, ItalyClinica Oculistica, Dipartimento di Scienze Chirugiche, Universita' di Torino, Via Juvarra 19, 10100 Torino, ItalyClinica Oculistica, Dipartimento di Scienze Chirugiche, Universita' di Torino, Via Juvarra 19, 10100 Torino, ItalyClinica Oculistica, Dipartimento di Scienze Chirugiche, Universita' di Torino, Via Juvarra 19, 10100 Torino, ItalyClinica Oculistica, Dipartimento di Scienze Chirugiche, Universita' di Torino, Via Juvarra 19, 10100 Torino, ItalyObjective. To evaluate the efficacy and safety of the Xen Gel Stent and provide a macro- and microscopic analyses of bleb morphology. Methods. A prospective 12-month study on patients with primary open-angle glaucoma. Patients underwent implantation of the XEN Gel Stent (Allergan INC, Dublin, Ireland) either alone or combined with a cataract surgery. Biomicroscopy, in vivo confocal microscopy (IVCM), and anterior segment-optical coherence tomography (AS-OCT) were used to assess bleb morphology. Safety parameters were adverse events, best corrected visual acuity, visual field, and corneal endothelial cell loss. A postoperative IOP ≤ 18 mmHg without or on medications was respectively defined as complete and qualified success while an IOP ≥ 18 mmHg was defined as failure. Results. Twelve eyes of 11 patients were evaluated. At one year, 5 out of 10 patients available achieved a complete success while five were qualified success. AS-OCT showed that bleb wall reflectivity was significantly higher in the failure group; IVCM revealed that stromal density was significantly lower in the success group. No safety issues were recorded. Conclusion. Implantation of the XEN Gel Stent appears to be a safe and effective procedure. AS-OCT and IVCM may be helpful in bleb assessment.http://dx.doi.org/10.1155/2017/9364910 |
| spellingShingle | Antonio Maria Fea Roberta Spinetta Paola Maria Loredana Cannizzo Giulia Consolandi Carlo Lavia Vittoria Aragno Francesco Germinetti Teresa Rolle Evaluation of Bleb Morphology and Reduction in IOP and Glaucoma Medication following Implantation of a Novel Gel Stent Journal of Ophthalmology |
| title | Evaluation of Bleb Morphology and Reduction in IOP and Glaucoma Medication following Implantation of a Novel Gel Stent |
| title_full | Evaluation of Bleb Morphology and Reduction in IOP and Glaucoma Medication following Implantation of a Novel Gel Stent |
| title_fullStr | Evaluation of Bleb Morphology and Reduction in IOP and Glaucoma Medication following Implantation of a Novel Gel Stent |
| title_full_unstemmed | Evaluation of Bleb Morphology and Reduction in IOP and Glaucoma Medication following Implantation of a Novel Gel Stent |
| title_short | Evaluation of Bleb Morphology and Reduction in IOP and Glaucoma Medication following Implantation of a Novel Gel Stent |
| title_sort | evaluation of bleb morphology and reduction in iop and glaucoma medication following implantation of a novel gel stent |
| url | http://dx.doi.org/10.1155/2017/9364910 |
| work_keys_str_mv | AT antoniomariafea evaluationofblebmorphologyandreductioniniopandglaucomamedicationfollowingimplantationofanovelgelstent AT robertaspinetta evaluationofblebmorphologyandreductioniniopandglaucomamedicationfollowingimplantationofanovelgelstent AT paolamarialoredanacannizzo evaluationofblebmorphologyandreductioniniopandglaucomamedicationfollowingimplantationofanovelgelstent AT giuliaconsolandi evaluationofblebmorphologyandreductioniniopandglaucomamedicationfollowingimplantationofanovelgelstent AT carlolavia evaluationofblebmorphologyandreductioniniopandglaucomamedicationfollowingimplantationofanovelgelstent AT vittoriaaragno evaluationofblebmorphologyandreductioniniopandglaucomamedicationfollowingimplantationofanovelgelstent AT francescogerminetti evaluationofblebmorphologyandreductioniniopandglaucomamedicationfollowingimplantationofanovelgelstent AT teresarolle evaluationofblebmorphologyandreductioniniopandglaucomamedicationfollowingimplantationofanovelgelstent |