The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets
Metallodrugs represent a critical area of medicinal chemistry with the potential to address a wide range of diseases. Their design requires a multidisciplinary approach, combining principles of inorganic chemistry, pharmacology, and molecular biology to create effective and safe therapeutic agents....
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MDPI AG
2024-10-01
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| Series: | Future Pharmacology |
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| Online Access: | https://www.mdpi.com/2673-9879/4/4/40 |
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| author | Otávio Augusto Chaves Francisco Mainardi Martins Carlos Serpa Davi Fernando Back |
| author_facet | Otávio Augusto Chaves Francisco Mainardi Martins Carlos Serpa Davi Fernando Back |
| author_sort | Otávio Augusto Chaves |
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| description | Metallodrugs represent a critical area of medicinal chemistry with the potential to address a wide range of diseases. Their design requires a multidisciplinary approach, combining principles of inorganic chemistry, pharmacology, and molecular biology to create effective and safe therapeutic agents. Vanadium, the element of the fifth group of the first transition series (3d metals), has been already detected as a crucial species in the biological action of some enzymes, e.g., nitrogenases and chloroperoxidase; furthermore, vanadium-based compounds have recently been described as physiologically stable with therapeutic behavior, e.g., having anticancer, antidiabetic (insulin-mimicking), antiprotozoal, antibacterial, antiviral, and inhibition of neurodegenerative disease properties. Since the binding of metallodrugs to serum albumin influences the distribution, stability, toxicity (intended and off-target interactions), and overall pharmacological properties, the biophysical characterization between serum albumin and vanadium-based compounds is one of the hot topics in pharmacology. Overall, since vanadium complexes offer new possibilities for the design of novel metallodrugs, this review summarized some up-to-date biological and medicinal aspects, highlighting proteins as the main targets for the inorganic complexes based on this transition metal. |
| format | Article |
| id | doaj-art-d8b8d4470c6b46f2b06225a1c83ede9d |
| institution | OA Journals |
| issn | 2673-9879 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Future Pharmacology |
| spelling | doaj-art-d8b8d4470c6b46f2b06225a1c83ede9d2025-08-20T02:00:33ZengMDPI AGFuture Pharmacology2673-98792024-10-014474377410.3390/futurepharmacol4040040The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein TargetsOtávio Augusto Chaves0Francisco Mainardi Martins1Carlos Serpa2Davi Fernando Back3Department of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences (CQC-IMS), University of Coimbra, Rua Larga, 3004-535 Coimbra, PortugalLaboratory of Inorganic Materials, Department of Chemistry, Center for Natural and Exact Sciences (CCNE), Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, BrazilDepartment of Chemistry, Coimbra Chemistry Centre-Institute of Molecular Sciences (CQC-IMS), University of Coimbra, Rua Larga, 3004-535 Coimbra, PortugalLaboratory of Inorganic Materials, Department of Chemistry, Center for Natural and Exact Sciences (CCNE), Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, BrazilMetallodrugs represent a critical area of medicinal chemistry with the potential to address a wide range of diseases. Their design requires a multidisciplinary approach, combining principles of inorganic chemistry, pharmacology, and molecular biology to create effective and safe therapeutic agents. Vanadium, the element of the fifth group of the first transition series (3d metals), has been already detected as a crucial species in the biological action of some enzymes, e.g., nitrogenases and chloroperoxidase; furthermore, vanadium-based compounds have recently been described as physiologically stable with therapeutic behavior, e.g., having anticancer, antidiabetic (insulin-mimicking), antiprotozoal, antibacterial, antiviral, and inhibition of neurodegenerative disease properties. Since the binding of metallodrugs to serum albumin influences the distribution, stability, toxicity (intended and off-target interactions), and overall pharmacological properties, the biophysical characterization between serum albumin and vanadium-based compounds is one of the hot topics in pharmacology. Overall, since vanadium complexes offer new possibilities for the design of novel metallodrugs, this review summarized some up-to-date biological and medicinal aspects, highlighting proteins as the main targets for the inorganic complexes based on this transition metal.https://www.mdpi.com/2673-9879/4/4/40drug discoverydrug developmentmetallodrugsvanadium-based compoundsenzymatic activityserum albumin |
| spellingShingle | Otávio Augusto Chaves Francisco Mainardi Martins Carlos Serpa Davi Fernando Back The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets Future Pharmacology drug discovery drug development metallodrugs vanadium-based compounds enzymatic activity serum albumin |
| title | The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets |
| title_full | The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets |
| title_fullStr | The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets |
| title_full_unstemmed | The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets |
| title_short | The Role of Vanadium in Metallodrugs Design and Its Interactive Profile with Protein Targets |
| title_sort | role of vanadium in metallodrugs design and its interactive profile with protein targets |
| topic | drug discovery drug development metallodrugs vanadium-based compounds enzymatic activity serum albumin |
| url | https://www.mdpi.com/2673-9879/4/4/40 |
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