Developing and Assessing a Scalable Digital Health Tool for Pretest Genetic Education in Patients With Early-Onset Colorectal Cancer: Mixed Methods Design
BackgroundNational guidelines recommend germline genetic testing (GT) for all patients with early-onset colorectal cancer. With recent advances in targeted therapies and GT, these guidelines are expected to expand to include broader groups of patients with colorectal cancer....
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JMIR Publications
2025-01-01
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| Series: | JMIR Cancer |
| Online Access: | https://cancer.jmir.org/2025/1/e59464 |
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| author | Jessica N Rivera Rivera Moran Snir Emilie Simmons Tara Schmidlen Misha Sholeh Melinda Leigh Maconi Carley Geiss Hayden Fulton Laura Barton Brian D Gonzalez Jennifer Permuth Susan Vadaparampil |
| author_facet | Jessica N Rivera Rivera Moran Snir Emilie Simmons Tara Schmidlen Misha Sholeh Melinda Leigh Maconi Carley Geiss Hayden Fulton Laura Barton Brian D Gonzalez Jennifer Permuth Susan Vadaparampil |
| author_sort | Jessica N Rivera Rivera |
| collection | DOAJ |
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BackgroundNational guidelines recommend germline genetic testing (GT) for all patients with early-onset colorectal cancer. With recent advances in targeted therapies and GT, these guidelines are expected to expand to include broader groups of patients with colorectal cancer. However, there is a shortage of genetic professionals to provide the necessary education and support for informed consent. As such, there is a pressing need to identify alternative approaches to facilitate and expedite access to GT.
ObjectiveThis study describes the development of a pretest education intervention, Nest-CRC, to facilitate the uptake of germline GT among patients with early-onset colorectal cancer. Patients with early-onset colorectal cancer and health care providers reviewed Nest-CRC, and their reactions and recommendations were captured using a nested mixed methods approach.
MethodsUsing the learner verification approach, we conducted 2 sequential phases of surveys and interviews with English- and Spanish-speaking patients with early-onset colorectal cancer and health care providers. The surveys assessed participants’ experiences with genetic services and provided immediate feedback on the Nest-CRC genetic education modules. Semistructured interviews evaluated participants’ perceptions of self-efficacy, attraction, comprehension, cultural acceptability, and usability of Nest-CRC. Survey data were analyzed using descriptive statistics (mean, median, and proportions), while interview data were analyzed through line-by-line coding of the transcribed interviews. After each phase, Nest-CRC was refined based on participants’ recommendations.
ResultsA total of 52 participants, including 39 patients with early-onset colorectal cancer and 13 providers, participated in the study. Of these, 19 patients and 6 providers participated in phase 1 (N=25), and 20 patients and 7 providers participated in phase 2 (N=27). Most participants (phase 1: 23/25, 92%, to 25/25, 100%; phase 2: 24/27, 89%, to 27/27, 100%) agreed that each of the 5 education modules was easy to understand and helpful; 13 patients reported no history of GT, with 11 (85%) expressing interest in GT and 2 (15%) remaining unsure after completing Nest-CRC. Participants reported that Nest-CRC provided sufficient information to help them decide about GT. The tool was deemed acceptable by individuals from diverse backgrounds, and participants found it visually attractive, easy to comprehend, and user-friendly.
ConclusionsThe findings revealed that Nest-CRC is a promising strategy for facilitating pretest education and promoting GT. Nest-CRC has been refined based on participant recommendations and will be re-evaluated. |
| format | Article |
| id | doaj-art-d8b7f3e809da4c44bd32144db52b2d62 |
| institution | Kabale University |
| issn | 2369-1999 |
| language | English |
| publishDate | 2025-01-01 |
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| series | JMIR Cancer |
| spelling | doaj-art-d8b7f3e809da4c44bd32144db52b2d622025-01-17T15:45:32ZengJMIR PublicationsJMIR Cancer2369-19992025-01-0111e5946410.2196/59464Developing and Assessing a Scalable Digital Health Tool for Pretest Genetic Education in Patients With Early-Onset Colorectal Cancer: Mixed Methods DesignJessica N Rivera Riverahttps://orcid.org/0000-0002-6675-0037Moran Snirhttps://orcid.org/0009-0006-3919-9506Emilie Simmonshttps://orcid.org/0009-0004-1646-8801Tara Schmidlenhttps://orcid.org/0000-0002-9749-112XMisha Sholehhttps://orcid.org/0009-0006-4189-4380Melinda Leigh Maconihttps://orcid.org/0000-0002-4357-2514Carley Geisshttps://orcid.org/0000-0003-3800-1132Hayden Fultonhttps://orcid.org/0000-0003-0486-6277Laura Bartonhttps://orcid.org/0000-0002-3750-5745Brian D Gonzalezhttps://orcid.org/0000-0001-5108-5735Jennifer Permuthhttps://orcid.org/0000-0002-4726-9264Susan Vadaparampilhttps://orcid.org/0000-0002-1052-6917 BackgroundNational guidelines recommend germline genetic testing (GT) for all patients with early-onset colorectal cancer. With recent advances in targeted therapies and GT, these guidelines are expected to expand to include broader groups of patients with colorectal cancer. However, there is a shortage of genetic professionals to provide the necessary education and support for informed consent. As such, there is a pressing need to identify alternative approaches to facilitate and expedite access to GT. ObjectiveThis study describes the development of a pretest education intervention, Nest-CRC, to facilitate the uptake of germline GT among patients with early-onset colorectal cancer. Patients with early-onset colorectal cancer and health care providers reviewed Nest-CRC, and their reactions and recommendations were captured using a nested mixed methods approach. MethodsUsing the learner verification approach, we conducted 2 sequential phases of surveys and interviews with English- and Spanish-speaking patients with early-onset colorectal cancer and health care providers. The surveys assessed participants’ experiences with genetic services and provided immediate feedback on the Nest-CRC genetic education modules. Semistructured interviews evaluated participants’ perceptions of self-efficacy, attraction, comprehension, cultural acceptability, and usability of Nest-CRC. Survey data were analyzed using descriptive statistics (mean, median, and proportions), while interview data were analyzed through line-by-line coding of the transcribed interviews. After each phase, Nest-CRC was refined based on participants’ recommendations. ResultsA total of 52 participants, including 39 patients with early-onset colorectal cancer and 13 providers, participated in the study. Of these, 19 patients and 6 providers participated in phase 1 (N=25), and 20 patients and 7 providers participated in phase 2 (N=27). Most participants (phase 1: 23/25, 92%, to 25/25, 100%; phase 2: 24/27, 89%, to 27/27, 100%) agreed that each of the 5 education modules was easy to understand and helpful; 13 patients reported no history of GT, with 11 (85%) expressing interest in GT and 2 (15%) remaining unsure after completing Nest-CRC. Participants reported that Nest-CRC provided sufficient information to help them decide about GT. The tool was deemed acceptable by individuals from diverse backgrounds, and participants found it visually attractive, easy to comprehend, and user-friendly. ConclusionsThe findings revealed that Nest-CRC is a promising strategy for facilitating pretest education and promoting GT. Nest-CRC has been refined based on participant recommendations and will be re-evaluated.https://cancer.jmir.org/2025/1/e59464 |
| spellingShingle | Jessica N Rivera Rivera Moran Snir Emilie Simmons Tara Schmidlen Misha Sholeh Melinda Leigh Maconi Carley Geiss Hayden Fulton Laura Barton Brian D Gonzalez Jennifer Permuth Susan Vadaparampil Developing and Assessing a Scalable Digital Health Tool for Pretest Genetic Education in Patients With Early-Onset Colorectal Cancer: Mixed Methods Design JMIR Cancer |
| title | Developing and Assessing a Scalable Digital Health Tool for Pretest Genetic Education in Patients With Early-Onset Colorectal Cancer: Mixed Methods Design |
| title_full | Developing and Assessing a Scalable Digital Health Tool for Pretest Genetic Education in Patients With Early-Onset Colorectal Cancer: Mixed Methods Design |
| title_fullStr | Developing and Assessing a Scalable Digital Health Tool for Pretest Genetic Education in Patients With Early-Onset Colorectal Cancer: Mixed Methods Design |
| title_full_unstemmed | Developing and Assessing a Scalable Digital Health Tool for Pretest Genetic Education in Patients With Early-Onset Colorectal Cancer: Mixed Methods Design |
| title_short | Developing and Assessing a Scalable Digital Health Tool for Pretest Genetic Education in Patients With Early-Onset Colorectal Cancer: Mixed Methods Design |
| title_sort | developing and assessing a scalable digital health tool for pretest genetic education in patients with early onset colorectal cancer mixed methods design |
| url | https://cancer.jmir.org/2025/1/e59464 |
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