ACE and chitotriosidase as possible predictive biomarkers for activity of sarcoidosis in correlation with PET/CT findings
Background: Sarcoidosis is a granulomatous disease which can afflict virtually any tissue in the human body, most commonly the mediastinal lymph nodes and lungs. Pathohistological confirmation is the gold standard in establishing a diagnosis; however, determining the activity of the disease requires...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582502287S.pdf |
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| author | Stjepanovic Mihailo Sumarac Zorica Grubac Drazenka Belic Slobodan Maric Nikola Djurdjevic Natasa Sumarac Aleksandar Jankovic Jelena Jovicic Snezana |
| author_facet | Stjepanovic Mihailo Sumarac Zorica Grubac Drazenka Belic Slobodan Maric Nikola Djurdjevic Natasa Sumarac Aleksandar Jankovic Jelena Jovicic Snezana |
| author_sort | Stjepanovic Mihailo |
| collection | DOAJ |
| description | Background: Sarcoidosis is a granulomatous disease which can afflict virtually any tissue in the human body, most commonly the mediastinal lymph nodes and lungs. Pathohistological confirmation is the gold standard in establishing a diagnosis; however, determining the activity of the disease requires multiple clinical, radiographic and laboratory procedures. PET/CT scan is considered the gold standard for determining the presence of active granuloma but has several significant limitations (radioactive material, cost, overall access to device). ACE and chitotriosidase are biomarkers used for diagnosing sarcoidosis and could have a place in determining the activity of the disease when compared with the results of PET/CT scans. Methods: We have compared the levels of ACE and chitotriosidase with the levels of SUVmax values in patients with sarcoidosis. Results: SUVmax and chitotriosidase levels were significantly correlated at the baseline and after the follow-up period, regardless of gender, age, duration of disease and radiography stage, while SUVmax and ACE levels were not. Chitotriosidase also showed a significant predictive ability to decrease the activity of sarcoidosis, which represented the decrease of SUVmax as the effect of therapy compared with ACE. Conclusions: In the absence of an ideal biomarker for sarcoidosis (high sensitivity, specificity and stability), chitotriosidase can be used in determining the activity of the disease, as it has shown a significant correlation to the gold standard-PET/CT scan. |
| format | Article |
| id | doaj-art-d8b6cec08b504ccbb55b445329bb3cdf |
| institution | DOAJ |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-d8b6cec08b504ccbb55b445329bb3cdf2025-08-20T02:54:50ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144228729310.5937/jomb0-509941452-82582502287SACE and chitotriosidase as possible predictive biomarkers for activity of sarcoidosis in correlation with PET/CT findingsStjepanovic Mihailo0https://orcid.org/0000-0003-1787-1438Sumarac Zorica1Grubac Drazenka2Belic Slobodan3Maric Nikola4https://orcid.org/0000-0002-1103-5669Djurdjevic Natasa5Sumarac Aleksandar6Jankovic Jelena7Jovicic Snezana8https://orcid.org/0000-0002-6878-8645University Clinical Centre of Serbia, Clinic of Pulmonology, Belgrade, SerbiaUniversity Clinical Centre of Serbia, Centre for Medical Biochemistry, Belgrade, SerbiaPublic Health Institution - Hospital Trebinje, Trebinje, Republic of Srpska, Bosnia and HerzegovinaUniversity Clinical Centre of Serbia, Clinic of Pulmonology, Belgrade, SerbiaUniversity Clinical Centre of Serbia, Clinic of Pulmonology, Belgrade, SerbiaUniversity Clinical Centre of Serbia, Clinic of Pulmonology, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity Clinical Centre of Serbia, Clinic of Pulmonology, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department for Medical Biochemistry, Belgrade, SerbiaBackground: Sarcoidosis is a granulomatous disease which can afflict virtually any tissue in the human body, most commonly the mediastinal lymph nodes and lungs. Pathohistological confirmation is the gold standard in establishing a diagnosis; however, determining the activity of the disease requires multiple clinical, radiographic and laboratory procedures. PET/CT scan is considered the gold standard for determining the presence of active granuloma but has several significant limitations (radioactive material, cost, overall access to device). ACE and chitotriosidase are biomarkers used for diagnosing sarcoidosis and could have a place in determining the activity of the disease when compared with the results of PET/CT scans. Methods: We have compared the levels of ACE and chitotriosidase with the levels of SUVmax values in patients with sarcoidosis. Results: SUVmax and chitotriosidase levels were significantly correlated at the baseline and after the follow-up period, regardless of gender, age, duration of disease and radiography stage, while SUVmax and ACE levels were not. Chitotriosidase also showed a significant predictive ability to decrease the activity of sarcoidosis, which represented the decrease of SUVmax as the effect of therapy compared with ACE. Conclusions: In the absence of an ideal biomarker for sarcoidosis (high sensitivity, specificity and stability), chitotriosidase can be used in determining the activity of the disease, as it has shown a significant correlation to the gold standard-PET/CT scan.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582502287S.pdfsarcoidosisacechitotriosidasepet/ctactivity |
| spellingShingle | Stjepanovic Mihailo Sumarac Zorica Grubac Drazenka Belic Slobodan Maric Nikola Djurdjevic Natasa Sumarac Aleksandar Jankovic Jelena Jovicic Snezana ACE and chitotriosidase as possible predictive biomarkers for activity of sarcoidosis in correlation with PET/CT findings Journal of Medical Biochemistry sarcoidosis ace chitotriosidase pet/ct activity |
| title | ACE and chitotriosidase as possible predictive biomarkers for activity of sarcoidosis in correlation with PET/CT findings |
| title_full | ACE and chitotriosidase as possible predictive biomarkers for activity of sarcoidosis in correlation with PET/CT findings |
| title_fullStr | ACE and chitotriosidase as possible predictive biomarkers for activity of sarcoidosis in correlation with PET/CT findings |
| title_full_unstemmed | ACE and chitotriosidase as possible predictive biomarkers for activity of sarcoidosis in correlation with PET/CT findings |
| title_short | ACE and chitotriosidase as possible predictive biomarkers for activity of sarcoidosis in correlation with PET/CT findings |
| title_sort | ace and chitotriosidase as possible predictive biomarkers for activity of sarcoidosis in correlation with pet ct findings |
| topic | sarcoidosis ace chitotriosidase pet/ct activity |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582502287S.pdf |
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