The Genoa Vascular Biobank: A Today Resource for Future Perspectives in Vascular Research
Background: Biological knowledge and patient care have been significantly improved by the emergence of big data analysis and -omics sciences, requiring high quality standards for biospecimen and data collection. Biobanks are complex and dynamic units designated to fulfill these needs. Objectives: Th...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-07-01
|
| Series: | Biomarker Insights |
| Online Access: | https://doi.org/10.1177/11772719251324322 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849414228763475968 |
|---|---|
| author | Chiara Barisione Jorge Miguel Mena Vera Caterina Ivaldo Silvia Ortona Pier Francesco Ferrari Paola Visconti Michele Paudice Martina Bastianon Caterina Melani Gaddiel Mozzetta Valerio Vellone Giovanni Pratesi Domenico Palombo |
| author_facet | Chiara Barisione Jorge Miguel Mena Vera Caterina Ivaldo Silvia Ortona Pier Francesco Ferrari Paola Visconti Michele Paudice Martina Bastianon Caterina Melani Gaddiel Mozzetta Valerio Vellone Giovanni Pratesi Domenico Palombo |
| author_sort | Chiara Barisione |
| collection | DOAJ |
| description | Background: Biological knowledge and patient care have been significantly improved by the emergence of big data analysis and -omics sciences, requiring high quality standards for biospecimen and data collection. Biobanks are complex and dynamic units designated to fulfill these needs. Objectives: The Genoa Vascular Biobank (GTB-VD) is a collaborative network between the IRCCS Ospedale Policlinico San Martino (Centre of Biological Resources), and the University of Genoa (Vascular and Endovascular Surgery Unit; Anatomic Pathology Unit; Laboratory of Clinical and Experimental Vascular Biology). This work describes workflow, ethic and governance requirements, demographic and clinical characteristics of subjects enrolled in the GTB-VD, and the volume of open or endovascular surgical interventions. Design: The GTB-VD recruits patients undergoing surgical repair for carotid artery stenosis (CS) and abdominal aortic aneurysm (AAA), enrolled on the basis of selection criteria and subdivided for pathology and type of intervention, upon informed consent. Methods: Biospecimens comprise serum, plasma, whole blood, peripheral blood mononuclear cells, and urine (from AAA only), stored at −80°C; lesions from open surgeries are frozen and formalin fixed paraffin embedded. Samples are associated with donor’s clinical data through pseudonymization to prevent patient identification. Data accuracy and sample quality are ensured by harmonized standard operative procedures. Results: From 2018 to the end of 2023, 442 CS (distinguished into severe-asymptomatic or symptomatic, displaying a ratio of 5:1) and 214 AAA have been collected. CS is more frequently associated with diabetes and peripheral artery diseases, AAA with pulmonary history, and renal function impairment. Open surgery is more used for CS and endovascular for AAA. Conclusion: The GTB–VD, as organized, represents an “ unicum ” in our Country; it supports studies to identify molecular targets and biomarkers associated with specific arteriopathy, for developing secondary prevention strategies and minimally invasive, in situ therapies. Collaborative studies and sample sharing are welcome. |
| format | Article |
| id | doaj-art-d8b53a3c499b4b3ba1566439bb5b5b70 |
| institution | Kabale University |
| issn | 1177-2719 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj-art-d8b53a3c499b4b3ba1566439bb5b5b702025-08-20T03:33:53ZengSAGE PublishingBiomarker Insights1177-27192025-07-012010.1177/11772719251324322The Genoa Vascular Biobank: A Today Resource for Future Perspectives in Vascular ResearchChiara Barisione0Jorge Miguel Mena Vera1Caterina Ivaldo2Silvia Ortona3Pier Francesco Ferrari4Paola Visconti5Michele Paudice6Martina Bastianon7Caterina Melani8Gaddiel Mozzetta9Valerio Vellone10Giovanni Pratesi11Domenico Palombo12Research Center for Biologically Inspired Engineering in Vascular Medicine and Longevity, University of Genoa, Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Genoa, ItalyDepartment of Surgical and Integrated Diagnostic Sciences, University of Genoa, Genoa, ItalyDepartment of Experimental Medicine, University of Genoa, Genoa, ItalyDepartment of Civil, Chemical and Environmental Engineering, University of Genoa, Genoa, ItalyIRCCS Ospedale Policlinico San Martino, Genoa, ItalyIRCCS Ospedale Policlinico San Martino, Genoa, ItalyIRCCS Ospedale Policlinico San Martino, Genoa, ItalyIRCCS Ospedale Policlinico San Martino, Genoa, ItalyIRCCS Ospedale Policlinico San Martino, Genoa, ItalyDepartment of Pathological Anatomy, IRCCS Ospedale Gaslini, Genoa, ItalyResearch Center for Biologically Inspired Engineering in Vascular Medicine and Longevity, University of Genoa, Genoa, ItalyResearch Center for Biologically Inspired Engineering in Vascular Medicine and Longevity, University of Genoa, Genoa, ItalyBackground: Biological knowledge and patient care have been significantly improved by the emergence of big data analysis and -omics sciences, requiring high quality standards for biospecimen and data collection. Biobanks are complex and dynamic units designated to fulfill these needs. Objectives: The Genoa Vascular Biobank (GTB-VD) is a collaborative network between the IRCCS Ospedale Policlinico San Martino (Centre of Biological Resources), and the University of Genoa (Vascular and Endovascular Surgery Unit; Anatomic Pathology Unit; Laboratory of Clinical and Experimental Vascular Biology). This work describes workflow, ethic and governance requirements, demographic and clinical characteristics of subjects enrolled in the GTB-VD, and the volume of open or endovascular surgical interventions. Design: The GTB-VD recruits patients undergoing surgical repair for carotid artery stenosis (CS) and abdominal aortic aneurysm (AAA), enrolled on the basis of selection criteria and subdivided for pathology and type of intervention, upon informed consent. Methods: Biospecimens comprise serum, plasma, whole blood, peripheral blood mononuclear cells, and urine (from AAA only), stored at −80°C; lesions from open surgeries are frozen and formalin fixed paraffin embedded. Samples are associated with donor’s clinical data through pseudonymization to prevent patient identification. Data accuracy and sample quality are ensured by harmonized standard operative procedures. Results: From 2018 to the end of 2023, 442 CS (distinguished into severe-asymptomatic or symptomatic, displaying a ratio of 5:1) and 214 AAA have been collected. CS is more frequently associated with diabetes and peripheral artery diseases, AAA with pulmonary history, and renal function impairment. Open surgery is more used for CS and endovascular for AAA. Conclusion: The GTB–VD, as organized, represents an “ unicum ” in our Country; it supports studies to identify molecular targets and biomarkers associated with specific arteriopathy, for developing secondary prevention strategies and minimally invasive, in situ therapies. Collaborative studies and sample sharing are welcome.https://doi.org/10.1177/11772719251324322 |
| spellingShingle | Chiara Barisione Jorge Miguel Mena Vera Caterina Ivaldo Silvia Ortona Pier Francesco Ferrari Paola Visconti Michele Paudice Martina Bastianon Caterina Melani Gaddiel Mozzetta Valerio Vellone Giovanni Pratesi Domenico Palombo The Genoa Vascular Biobank: A Today Resource for Future Perspectives in Vascular Research Biomarker Insights |
| title | The Genoa Vascular Biobank: A Today Resource for Future Perspectives in Vascular Research |
| title_full | The Genoa Vascular Biobank: A Today Resource for Future Perspectives in Vascular Research |
| title_fullStr | The Genoa Vascular Biobank: A Today Resource for Future Perspectives in Vascular Research |
| title_full_unstemmed | The Genoa Vascular Biobank: A Today Resource for Future Perspectives in Vascular Research |
| title_short | The Genoa Vascular Biobank: A Today Resource for Future Perspectives in Vascular Research |
| title_sort | genoa vascular biobank a today resource for future perspectives in vascular research |
| url | https://doi.org/10.1177/11772719251324322 |
| work_keys_str_mv | AT chiarabarisione thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT jorgemiguelmenavera thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT caterinaivaldo thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT silviaortona thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT pierfrancescoferrari thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT paolavisconti thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT michelepaudice thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT martinabastianon thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT caterinamelani thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT gaddielmozzetta thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT valeriovellone thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT giovannipratesi thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT domenicopalombo thegenoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT chiarabarisione genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT jorgemiguelmenavera genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT caterinaivaldo genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT silviaortona genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT pierfrancescoferrari genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT paolavisconti genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT michelepaudice genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT martinabastianon genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT caterinamelani genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT gaddielmozzetta genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT valeriovellone genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT giovannipratesi genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch AT domenicopalombo genoavascularbiobankatodayresourceforfutureperspectivesinvascularresearch |