The Role of Chemosensory Proteins in Insecticide Resistance: A Review
Chemosensory proteins (CSPs) are small soluble proteins found predominantly in insects, with a conserved structure that contains a hydrophobic cavity. While originally associated with chemosensation, they were soon implicated to several other functions related to their ability to bind hydrophobic mo...
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MDPI AG
2025-05-01
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| Series: | Insects |
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| Online Access: | https://www.mdpi.com/2075-4450/16/5/496 |
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| author | Angeliki Tsouri Vassilis Douris |
| author_facet | Angeliki Tsouri Vassilis Douris |
| author_sort | Angeliki Tsouri |
| collection | DOAJ |
| description | Chemosensory proteins (CSPs) are small soluble proteins found predominantly in insects, with a conserved structure that contains a hydrophobic cavity. While originally associated with chemosensation, they were soon implicated to several other functions related to their ability to bind hydrophobic molecules. Research in the last decade has shown that CSPs may play a role in insecticide resistance. Several <i>CSP</i> genes are upregulated upon induction by sublethal insecticide doses or are highly expressed in resistant populations. RNA interference of <i>CSP</i> genes can restore susceptibility to insecticides. In vitro binding assays and molecular docking simulations suggest that CSPs can strongly bind to insecticides and can accommodate even large molecules in their hydrophobic cavities. Some cases of <i>CSP</i> overexpression in transgenic insects conferring insecticide resistance are reported. Taken together, these results indicate a role for CSPs in insecticide resistance, presumably through a sequestration mechanism, perhaps in combination with other mechanisms like metabolic resistance. This article reviews the evidence for CSP involvement in resistance and discusses ongoing research in the field. |
| format | Article |
| id | doaj-art-d8b44d195e5f477fa85f1c708aeeeb2a |
| institution | OA Journals |
| issn | 2075-4450 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Insects |
| spelling | doaj-art-d8b44d195e5f477fa85f1c708aeeeb2a2025-08-20T02:34:00ZengMDPI AGInsects2075-44502025-05-0116549610.3390/insects16050496The Role of Chemosensory Proteins in Insecticide Resistance: A ReviewAngeliki Tsouri0Vassilis Douris1Department of Biological Applications and Technology, University of Ioannina, 45110 Ioannina, GreeceDepartment of Biological Applications and Technology, University of Ioannina, 45110 Ioannina, GreeceChemosensory proteins (CSPs) are small soluble proteins found predominantly in insects, with a conserved structure that contains a hydrophobic cavity. While originally associated with chemosensation, they were soon implicated to several other functions related to their ability to bind hydrophobic molecules. Research in the last decade has shown that CSPs may play a role in insecticide resistance. Several <i>CSP</i> genes are upregulated upon induction by sublethal insecticide doses or are highly expressed in resistant populations. RNA interference of <i>CSP</i> genes can restore susceptibility to insecticides. In vitro binding assays and molecular docking simulations suggest that CSPs can strongly bind to insecticides and can accommodate even large molecules in their hydrophobic cavities. Some cases of <i>CSP</i> overexpression in transgenic insects conferring insecticide resistance are reported. Taken together, these results indicate a role for CSPs in insecticide resistance, presumably through a sequestration mechanism, perhaps in combination with other mechanisms like metabolic resistance. This article reviews the evidence for CSP involvement in resistance and discusses ongoing research in the field.https://www.mdpi.com/2075-4450/16/5/496chemosensory proteinsinsecticide resistanceresistance mechanismssynergistic interactions |
| spellingShingle | Angeliki Tsouri Vassilis Douris The Role of Chemosensory Proteins in Insecticide Resistance: A Review Insects chemosensory proteins insecticide resistance resistance mechanisms synergistic interactions |
| title | The Role of Chemosensory Proteins in Insecticide Resistance: A Review |
| title_full | The Role of Chemosensory Proteins in Insecticide Resistance: A Review |
| title_fullStr | The Role of Chemosensory Proteins in Insecticide Resistance: A Review |
| title_full_unstemmed | The Role of Chemosensory Proteins in Insecticide Resistance: A Review |
| title_short | The Role of Chemosensory Proteins in Insecticide Resistance: A Review |
| title_sort | role of chemosensory proteins in insecticide resistance a review |
| topic | chemosensory proteins insecticide resistance resistance mechanisms synergistic interactions |
| url | https://www.mdpi.com/2075-4450/16/5/496 |
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