Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability.

Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability.

Normal heart function requires generation of a regular rhythm by sinoatrial pacemaker cells and the alteration of this spontaneous heart rate by the autonomic input to match physiological demand. However, the molecular mechanisms that ensure consistent periodicity of cardiac contractions and fine tu...

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Bibliographic Details
Main Authors: Ekaterina Posokhova, David Ng, Aaisha Opel, Ikuo Masuho, Andrew Tinker, Leslie G Biesecker, Kevin Wickman, Kirill A Martemyanov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0076973
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