STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer

STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer

In the clinic, anti-tumor angiogenesis is commonly employed for treating recurrent, metastatic, drug-resistant triple-negative, and advanced breast cancer. Our previous research revealed that the deubiquitinase STAMBPL1 enhances the stability of MKP-1, thereby promoting cisplatin resistance in breas...

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Bibliographic Details
Main Authors: Huan Fang, Huichun Liang, Chuanyu Yang, Dewei Jiang, Qianmei Luo, Wen-Ming Cao, Huifeng Zhang, Ceshi Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
triple-negative breast cancer
tumor angiogenesis
STAMBPL1
FOXO1
GRHL3
HIF1α
Online Access:https://elifesciences.org/articles/102433
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