Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein B
Abstract Apolipoprotein B (apoB) can be measured directly and accurately, and better predicts atherogenic risk than conventional lipid profiles. We aimed to investigate whether total and regional (trunk or leg) fat deposits are associated with apoB levels in general US adults. 4585 participants were...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-10502-3 |
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| author | Chi Chen Yimeng Gu Junfei Xu Yanyan Xiao Chao Wang Yuan Chen Hui Huang Qingguang Chen Yilei Chen Qi Chen Ningjian Wang Hao Lu |
| author_facet | Chi Chen Yimeng Gu Junfei Xu Yanyan Xiao Chao Wang Yuan Chen Hui Huang Qingguang Chen Yilei Chen Qi Chen Ningjian Wang Hao Lu |
| author_sort | Chi Chen |
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| description | Abstract Apolipoprotein B (apoB) can be measured directly and accurately, and better predicts atherogenic risk than conventional lipid profiles. We aimed to investigate whether total and regional (trunk or leg) fat deposits are associated with apoB levels in general US adults. 4585 participants were enrolled from the US National Health and Nutritional Surveys from 2011 to 2016. Overall and regional body fat were measured using dual-energy X-ray absorptiometry. The associations of total and regional fat with apoB levels were evaluated using linear regression models. Following adjustment for demographic, lifestyle, and clinical risk factors, whole-body fat percentage was positively associated with apoB levels. Additionally, percent trunk fat was positively associated (highest vs. lowest tertile beta = 17.73 for men and 14.89 for women, respectively), whereas percent leg fat was inversely associated (highest vs. lowest tertile beta = − 4.84 for men and − 6.55 for women, respectively) with apoB levels in both sexes. The association for trunk fat and leg fat remained significant after further adjustment for body mass index or waist circumference. Higher percent trunk fat combined with lower percent leg fat was associated with particularly higher apoB. In conclusion, among general US adults, both elevated trunk fat and reduced leg fat are associated with higher levels of apoB. Further research is required to elucidate the underlying pathophysiological mechanisms. |
| format | Article |
| id | doaj-art-d8b0f0b4da3e4d14b4ee388d357c17b6 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-d8b0f0b4da3e4d14b4ee388d357c17b62025-08-20T03:45:52ZengNature PortfolioScientific Reports2045-23222025-07-011511810.1038/s41598-025-10502-3Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein BChi Chen0Yimeng Gu1Junfei Xu2Yanyan Xiao3Chao Wang4Yuan Chen5Hui Huang6Qingguang Chen7Yilei Chen8Qi Chen9Ningjian Wang10Hao Lu11Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineDepartment of Traditional Chinese Medicine, Henan Provincial People’s HospitalDepartment of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of MedicineInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Endocrinology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineAbstract Apolipoprotein B (apoB) can be measured directly and accurately, and better predicts atherogenic risk than conventional lipid profiles. We aimed to investigate whether total and regional (trunk or leg) fat deposits are associated with apoB levels in general US adults. 4585 participants were enrolled from the US National Health and Nutritional Surveys from 2011 to 2016. Overall and regional body fat were measured using dual-energy X-ray absorptiometry. The associations of total and regional fat with apoB levels were evaluated using linear regression models. Following adjustment for demographic, lifestyle, and clinical risk factors, whole-body fat percentage was positively associated with apoB levels. Additionally, percent trunk fat was positively associated (highest vs. lowest tertile beta = 17.73 for men and 14.89 for women, respectively), whereas percent leg fat was inversely associated (highest vs. lowest tertile beta = − 4.84 for men and − 6.55 for women, respectively) with apoB levels in both sexes. The association for trunk fat and leg fat remained significant after further adjustment for body mass index or waist circumference. Higher percent trunk fat combined with lower percent leg fat was associated with particularly higher apoB. In conclusion, among general US adults, both elevated trunk fat and reduced leg fat are associated with higher levels of apoB. Further research is required to elucidate the underlying pathophysiological mechanisms.https://doi.org/10.1038/s41598-025-10502-3Apolipoprotein BBody fatDual-energy X-ray absorptiometryNHANES |
| spellingShingle | Chi Chen Yimeng Gu Junfei Xu Yanyan Xiao Chao Wang Yuan Chen Hui Huang Qingguang Chen Yilei Chen Qi Chen Ningjian Wang Hao Lu Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein B Scientific Reports Apolipoprotein B Body fat Dual-energy X-ray absorptiometry NHANES |
| title | Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein B |
| title_full | Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein B |
| title_fullStr | Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein B |
| title_full_unstemmed | Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein B |
| title_short | Association between total and regional body fat measured by dual-energy X-ray absorptiometry and apolipoprotein B |
| title_sort | association between total and regional body fat measured by dual energy x ray absorptiometry and apolipoprotein b |
| topic | Apolipoprotein B Body fat Dual-energy X-ray absorptiometry NHANES |
| url | https://doi.org/10.1038/s41598-025-10502-3 |
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