Radiation-induced premature ovarian failure: focus on the role of ovarian inflammatory signaling pathways
Radiation therapy, an effective treatment modality for many types of cancer, often carries a heavy cost for young women. In particular, those undergoing pelvic radiotherapy mostly experience sudden menopausal symptoms and premature ovarian failure (POF) impacting their reproductive health and overal...
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| Language: | English |
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Ain Shams University
2023-12-01
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| Series: | Archives of Pharmaceutical Sciences Ain Shams University |
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| Online Access: | https://aps.journals.ekb.eg/article_332179.html |
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| author | Doaa H. Mohamed Eman M. Mantawy Riham S. Said Dina H. Kassem Amany M. Gad Ebtehal El-Demerdash |
| author_facet | Doaa H. Mohamed Eman M. Mantawy Riham S. Said Dina H. Kassem Amany M. Gad Ebtehal El-Demerdash |
| author_sort | Doaa H. Mohamed |
| collection | DOAJ |
| description | Radiation therapy, an effective treatment modality for many types of cancer, often carries a heavy cost for young women. In particular, those undergoing pelvic radiotherapy mostly experience sudden menopausal symptoms and premature ovarian failure (POF) impacting their reproductive health and overall quality of life. Upon radiation, excessive reactive oxygen species (ROS) are produced causing a state of oxidative stress to tissues. Following this, DNA is damaged augmenting subsequent inflammatory responses and further tissue damage. Mild inflammation is essential for the development and release of oocytes; however, Pro-longed inflammation is associated with poor quality oocytes and sometimes complete dysfunction of the ovaries, as excessively produced, pro-inflammatory cytokines like Tumor necrosis factor-alpha (TNF-α) and interleukins lead to compromised ovary functionality. This work aims at considering the radiation induced POF as an inflammatory process. It also covers key molecular pathways involved in this response like nuclear factor kappa-B (NFκ-b), Transforming growth factor-β (TGF-β), Mitogen-activated protein kinase (MAPK), Sirtuin 1 (SIRT1), Poly [ADP-ribose] polymerase 1 and insulin like growth factor-1 (IGF-1) in regulating inflammation. Eventually, understanding these interrelated pathways can provide researchers with valuable molecular targets that can be used to develop new protective agents for radiation induced POF and thus improve the quality of life for these patients. |
| format | Article |
| id | doaj-art-d8aaa41fc6d1432f8e7db03e385c9afc |
| institution | OA Journals |
| issn | 2356-8380 2356-8399 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Ain Shams University |
| record_format | Article |
| series | Archives of Pharmaceutical Sciences Ain Shams University |
| spelling | doaj-art-d8aaa41fc6d1432f8e7db03e385c9afc2025-08-20T02:32:27ZengAin Shams UniversityArchives of Pharmaceutical Sciences Ain Shams University2356-83802356-83992023-12-0172522538https://doi.org/10.21608/aps.2023.251808.1147Radiation-induced premature ovarian failure: focus on the role of ovarian inflammatory signaling pathwaysDoaa H. Mohamed0Eman M. Mantawy1Riham S. Said2Dina H. Kassem 3Amany M. Gad 4Ebtehal El-Demerdash5Central Administration of Drug Control, Egyptian Drug Authority (EDA), Formerly NODCAR, Giza 11553, Egypt.Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.Department of Drug Radiation Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt. Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt5 Department of Pharmacology & Toxicology Department, Faculty of Pharmacy, Sinai University (Kantara Branch) 41636, Egypt. 6 Department of Pharmacology, Egyptian Drug Authority, EDA, Formerly NODCAR, Giza 11553, Egypt.Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.Radiation therapy, an effective treatment modality for many types of cancer, often carries a heavy cost for young women. In particular, those undergoing pelvic radiotherapy mostly experience sudden menopausal symptoms and premature ovarian failure (POF) impacting their reproductive health and overall quality of life. Upon radiation, excessive reactive oxygen species (ROS) are produced causing a state of oxidative stress to tissues. Following this, DNA is damaged augmenting subsequent inflammatory responses and further tissue damage. Mild inflammation is essential for the development and release of oocytes; however, Pro-longed inflammation is associated with poor quality oocytes and sometimes complete dysfunction of the ovaries, as excessively produced, pro-inflammatory cytokines like Tumor necrosis factor-alpha (TNF-α) and interleukins lead to compromised ovary functionality. This work aims at considering the radiation induced POF as an inflammatory process. It also covers key molecular pathways involved in this response like nuclear factor kappa-B (NFκ-b), Transforming growth factor-β (TGF-β), Mitogen-activated protein kinase (MAPK), Sirtuin 1 (SIRT1), Poly [ADP-ribose] polymerase 1 and insulin like growth factor-1 (IGF-1) in regulating inflammation. Eventually, understanding these interrelated pathways can provide researchers with valuable molecular targets that can be used to develop new protective agents for radiation induced POF and thus improve the quality of life for these patients.https://aps.journals.ekb.eg/article_332179.htmldepartment of pharmacologyegyptian drug authorityedaformerly nodcargiza 11553egypt |
| spellingShingle | Doaa H. Mohamed Eman M. Mantawy Riham S. Said Dina H. Kassem Amany M. Gad Ebtehal El-Demerdash Radiation-induced premature ovarian failure: focus on the role of ovarian inflammatory signaling pathways Archives of Pharmaceutical Sciences Ain Shams University department of pharmacology egyptian drug authority eda formerly nodcar giza 11553 egypt |
| title | Radiation-induced premature ovarian failure: focus on the role of ovarian inflammatory signaling pathways |
| title_full | Radiation-induced premature ovarian failure: focus on the role of ovarian inflammatory signaling pathways |
| title_fullStr | Radiation-induced premature ovarian failure: focus on the role of ovarian inflammatory signaling pathways |
| title_full_unstemmed | Radiation-induced premature ovarian failure: focus on the role of ovarian inflammatory signaling pathways |
| title_short | Radiation-induced premature ovarian failure: focus on the role of ovarian inflammatory signaling pathways |
| title_sort | radiation induced premature ovarian failure focus on the role of ovarian inflammatory signaling pathways |
| topic | department of pharmacology egyptian drug authority eda formerly nodcar giza 11553 egypt |
| url | https://aps.journals.ekb.eg/article_332179.html |
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