The East London Parkinson’s disease project – a case-control study of Parkinson’s Disease in a diverse population
Abstract There is a relative dearth of research on patients with Parkinson’s disease (PD) from under-represented ethnic groups in the United Kingdom. The East London Parkinson Disease project seeks to understand the clinical manifestations and determinants of PD in a diverse population. Data on clin...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01031-x |
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| author | Alexandra Zirra Kamalesh C. Dey Ellen Camboe Sheena Waters Tahrina Haque Brook Huxford Harneek Chohan Natalie Donkor Joshua Kahan Aaron Ben-Joseph David A. Gallagher Caroline Budu Thomas Boyle Cristina Simonet Andrew J. Lees Charles R. Marshall Alastair J. Noyce |
| author_facet | Alexandra Zirra Kamalesh C. Dey Ellen Camboe Sheena Waters Tahrina Haque Brook Huxford Harneek Chohan Natalie Donkor Joshua Kahan Aaron Ben-Joseph David A. Gallagher Caroline Budu Thomas Boyle Cristina Simonet Andrew J. Lees Charles R. Marshall Alastair J. Noyce |
| author_sort | Alexandra Zirra |
| collection | DOAJ |
| description | Abstract There is a relative dearth of research on patients with Parkinson’s disease (PD) from under-represented ethnic groups in the United Kingdom. The East London Parkinson Disease project seeks to understand the clinical manifestations and determinants of PD in a diverse population. Data on clinical features were collected, between 2019 and 2024. We assessed 218 patients with PD and 90 controls. Among them, 50% of patients and 64% controls identified as South Asian or Black. South Asian and Black patients had significantly worse motor scores compared to White patients (mean [SD], 42.2 [18.8], and 47.0 [16.6] vs 35.2 [16.4], p < 0.001 and p < 0.001). Cognitive impairment was more prevalent in South Asian (73%) and Black patients (75%) than in White patients (45%, p = 0.002). Our results suggest that patients with PD from South Asian and Black ethnic groups may have more severe motor and certain non-motor features, including cognitive impairment, compared to White patients. |
| format | Article |
| id | doaj-art-d8a076e813e644ce800fb8c42447222e |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-d8a076e813e644ce800fb8c42447222e2025-08-20T03:47:24ZengNature Portfolionpj Parkinson's Disease2373-80572025-06-011111810.1038/s41531-025-01031-xThe East London Parkinson’s disease project – a case-control study of Parkinson’s Disease in a diverse populationAlexandra Zirra0Kamalesh C. Dey1Ellen Camboe2Sheena Waters3Tahrina Haque4Brook Huxford5Harneek Chohan6Natalie Donkor7Joshua Kahan8Aaron Ben-Joseph9David A. Gallagher10Caroline Budu11Thomas Boyle12Cristina Simonet13Andrew J. Lees14Charles R. Marshall15Alastair J. Noyce16Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonNeurology Department, Royal London Hospital, Barts Health NHS TrustNeurology Department, Royal London Hospital, Barts Health NHS TrustCare of the Elderly Department, Royal London Hospital, Barts Health NHS TrustCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonRita Lila Weston Institute of Neurological Studies, University College LondonCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of LondonAbstract There is a relative dearth of research on patients with Parkinson’s disease (PD) from under-represented ethnic groups in the United Kingdom. The East London Parkinson Disease project seeks to understand the clinical manifestations and determinants of PD in a diverse population. Data on clinical features were collected, between 2019 and 2024. We assessed 218 patients with PD and 90 controls. Among them, 50% of patients and 64% controls identified as South Asian or Black. South Asian and Black patients had significantly worse motor scores compared to White patients (mean [SD], 42.2 [18.8], and 47.0 [16.6] vs 35.2 [16.4], p < 0.001 and p < 0.001). Cognitive impairment was more prevalent in South Asian (73%) and Black patients (75%) than in White patients (45%, p = 0.002). Our results suggest that patients with PD from South Asian and Black ethnic groups may have more severe motor and certain non-motor features, including cognitive impairment, compared to White patients.https://doi.org/10.1038/s41531-025-01031-x |
| spellingShingle | Alexandra Zirra Kamalesh C. Dey Ellen Camboe Sheena Waters Tahrina Haque Brook Huxford Harneek Chohan Natalie Donkor Joshua Kahan Aaron Ben-Joseph David A. Gallagher Caroline Budu Thomas Boyle Cristina Simonet Andrew J. Lees Charles R. Marshall Alastair J. Noyce The East London Parkinson’s disease project – a case-control study of Parkinson’s Disease in a diverse population npj Parkinson's Disease |
| title | The East London Parkinson’s disease project – a case-control study of Parkinson’s Disease in a diverse population |
| title_full | The East London Parkinson’s disease project – a case-control study of Parkinson’s Disease in a diverse population |
| title_fullStr | The East London Parkinson’s disease project – a case-control study of Parkinson’s Disease in a diverse population |
| title_full_unstemmed | The East London Parkinson’s disease project – a case-control study of Parkinson’s Disease in a diverse population |
| title_short | The East London Parkinson’s disease project – a case-control study of Parkinson’s Disease in a diverse population |
| title_sort | east london parkinson s disease project a case control study of parkinson s disease in a diverse population |
| url | https://doi.org/10.1038/s41531-025-01031-x |
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