Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population
Objective To investigate the associations of the oral microbiome status with diabetes characteristics in elderly patients with type 2 diabetes mellitus.Methods A questionnaire was used to assess age, sex, smoking status, drinking status, flossing frequency, T2DM duration and complications, and a blo...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Oral Microbiology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2024.2345942 |
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| author | Xin Zeng Shuqi Huang Xin Ye Siping Song Jing He Liwei Hu Sicheng Deng Fan Liu |
| author_facet | Xin Zeng Shuqi Huang Xin Ye Siping Song Jing He Liwei Hu Sicheng Deng Fan Liu |
| author_sort | Xin Zeng |
| collection | DOAJ |
| description | Objective To investigate the associations of the oral microbiome status with diabetes characteristics in elderly patients with type 2 diabetes mellitus.Methods A questionnaire was used to assess age, sex, smoking status, drinking status, flossing frequency, T2DM duration and complications, and a blood test was used to determine the glycated haemoglobin (HbA1c) level. Sequencing of the V3-V4 region of the 16S rRNA gene from saliva samples was used to analyze the oral microbiome.Results Differential analysis revealed that Streptococcus and Weissella were significantly enriched in the late-stage group, and Capnocytophaga was significantly enriched in the early-stage group. Correlation analysis revealed that diabetes duration was positively correlated with the abundance of Streptococcus (r= 0.369, p= 0.007) and negatively correlated with the abundance of Cardiobacterium (r= -0.337, p= 0.014), and the level of HbA1c was not significantly correlated with the oral microbiome. Network analysis suggested that the poor control group had a more complex microbial network than the control group, a pattern that was similar for diabetes duration. In addition, Streptococcus has a low correlation with other microorganisms.Conclusion In elderly individuals, Streptococcus emerges as a potential biomarker linked to diabetes, exhibiting elevated abundance in diabetic patients influenced by disease exposure and limited bacterial interactions. |
| format | Article |
| id | doaj-art-d89314aa5bb14adba23498fe5ccf8299 |
| institution | DOAJ |
| issn | 2000-2297 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj-art-d89314aa5bb14adba23498fe5ccf82992025-08-20T02:48:11ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972024-12-0116110.1080/20002297.2024.2345942Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly populationXin Zeng0Shuqi Huang1Xin Ye2Siping Song3Jing He4Liwei Hu5Sicheng Deng6Fan Liu7West China School of Nursing, Sichuan University, Chengdu, ChinaNursing Department, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaWest China School of Nursing, Sichuan University, Chengdu, ChinaPost anesthesia Care Unit, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Oral Mucosal Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Oral Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaWest China School of Nursing, Sichuan University, Chengdu, ChinaNursing Department, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaObjective To investigate the associations of the oral microbiome status with diabetes characteristics in elderly patients with type 2 diabetes mellitus.Methods A questionnaire was used to assess age, sex, smoking status, drinking status, flossing frequency, T2DM duration and complications, and a blood test was used to determine the glycated haemoglobin (HbA1c) level. Sequencing of the V3-V4 region of the 16S rRNA gene from saliva samples was used to analyze the oral microbiome.Results Differential analysis revealed that Streptococcus and Weissella were significantly enriched in the late-stage group, and Capnocytophaga was significantly enriched in the early-stage group. Correlation analysis revealed that diabetes duration was positively correlated with the abundance of Streptococcus (r= 0.369, p= 0.007) and negatively correlated with the abundance of Cardiobacterium (r= -0.337, p= 0.014), and the level of HbA1c was not significantly correlated with the oral microbiome. Network analysis suggested that the poor control group had a more complex microbial network than the control group, a pattern that was similar for diabetes duration. In addition, Streptococcus has a low correlation with other microorganisms.Conclusion In elderly individuals, Streptococcus emerges as a potential biomarker linked to diabetes, exhibiting elevated abundance in diabetic patients influenced by disease exposure and limited bacterial interactions.https://www.tandfonline.com/doi/10.1080/20002297.2024.2345942Elderly individualstype 2 diabetes mellitusoral microbiomeglycated haemoglobindiabetes duration |
| spellingShingle | Xin Zeng Shuqi Huang Xin Ye Siping Song Jing He Liwei Hu Sicheng Deng Fan Liu Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population Journal of Oral Microbiology Elderly individuals type 2 diabetes mellitus oral microbiome glycated haemoglobin diabetes duration |
| title | Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population |
| title_full | Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population |
| title_fullStr | Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population |
| title_full_unstemmed | Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population |
| title_short | Impact of HbA1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population |
| title_sort | impact of hba1c control and type 2 diabetes mellitus exposure on the oral microbiome profile in the elderly population |
| topic | Elderly individuals type 2 diabetes mellitus oral microbiome glycated haemoglobin diabetes duration |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2024.2345942 |
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