Feasibility and outcomes of PCI with novel tapered coronary stent in people living with HIV: A prospective, single-center study with literature review
Background and objective: Patients with chronic HIV infection face a high risk of premature coronary atherosclerosis, partly due to continuous HAART therapy and susceptibility to opportunistic infections, complicating percutaneous coronary intervention (PCI). HIV patients have unique coronary vascul...
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Elsevier
2025-03-01
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| Series: | Indian Heart Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483225000471 |
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| author | H.S. Natraj Setty B.H. Natesh M.C. Yeriswamy V.A. Sathwik Raj Rahul S. Patil H.B. Chetan Kumar L. Sridhar Shastry B.C. Srinivas Babu Reddy Jayashree Kharge C.M. Nagesh S. Manohar C.M. Satwik K.H. Srinivas Santhosh Jadav K.S. Subramani Sadanand Vijay Kumar K.S. Ravindranath |
| author_facet | H.S. Natraj Setty B.H. Natesh M.C. Yeriswamy V.A. Sathwik Raj Rahul S. Patil H.B. Chetan Kumar L. Sridhar Shastry B.C. Srinivas Babu Reddy Jayashree Kharge C.M. Nagesh S. Manohar C.M. Satwik K.H. Srinivas Santhosh Jadav K.S. Subramani Sadanand Vijay Kumar K.S. Ravindranath |
| author_sort | H.S. Natraj Setty |
| collection | DOAJ |
| description | Background and objective: Patients with chronic HIV infection face a high risk of premature coronary atherosclerosis, partly due to continuous HAART therapy and susceptibility to opportunistic infections, complicating percutaneous coronary intervention (PCI). HIV patients have unique coronary vasculature characteristics. This study aimed to assess the clinical outcomes of PCI using the novel tapered sirolimus-eluting coronary stent (SES) system in HIV patients. Methods: A prospective, single-arm, non-randomized study was conducted at a tertiary cardiac care center, including 15 HIV-positive patients with acute coronary syndromes. PCI was performed using the study device for de novo coronary lesions with significant size disparity between reference vessel segments. The cumulative incidence of major adverse cardiovascular events (MACE), defined as cardiac death, myocardial infarction, and clinically driven target-lesion revascularization (CD-TLR), was the primary endpoint. Results: Since 2018, 15 HIV-positive patients with a mean age of 50.67 years underwent PCI with the study device. Despite cardiac risk factors and complex lesions, 100 % procedural and device success was achieved by restoring myocardial flow (TIMI flow III). Over a median follow-up of 40 months, no MACE or adverse events were recorded. Conclusions: This study provides new evidence on the use of the long, tapered SES for treating HIV-positive patients, demonstrating high success rates and favorable long-term outcomes. It is the first report of such outcomes using a long, tapered SES in this population. |
| format | Article |
| id | doaj-art-d88fc471ea6a49d7b4fe181f49c9ea94 |
| institution | OA Journals |
| issn | 0019-4832 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Heart Journal |
| spelling | doaj-art-d88fc471ea6a49d7b4fe181f49c9ea942025-08-20T01:55:33ZengElsevierIndian Heart Journal0019-48322025-03-0177211712110.1016/j.ihj.2025.03.001Feasibility and outcomes of PCI with novel tapered coronary stent in people living with HIV: A prospective, single-center study with literature reviewH.S. Natraj Setty0B.H. Natesh1M.C. Yeriswamy2V.A. Sathwik Raj3Rahul S. Patil4H.B. Chetan Kumar5L. Sridhar Shastry6B.C. Srinivas7Babu Reddy8Jayashree Kharge9C.M. Nagesh10S. Manohar11C.M. Satwik12K.H. Srinivas13Santhosh Jadav14K.S. Subramani15 Sadanand16Vijay Kumar17K.S. Ravindranath18Corresponding author. Sri Jayadeva Institute of Cardiovascular Sciences and Research, ''Sri Maruthi Nilaya'', No 598, 12th A Cross, 8th Main, Jeevan Gruha Colony, JP Nagar 2nd Phase, Near Dalmia Circle, Bangalore, Karnataka, 560078, India.; Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, Karnataka, IndiaBackground and objective: Patients with chronic HIV infection face a high risk of premature coronary atherosclerosis, partly due to continuous HAART therapy and susceptibility to opportunistic infections, complicating percutaneous coronary intervention (PCI). HIV patients have unique coronary vasculature characteristics. This study aimed to assess the clinical outcomes of PCI using the novel tapered sirolimus-eluting coronary stent (SES) system in HIV patients. Methods: A prospective, single-arm, non-randomized study was conducted at a tertiary cardiac care center, including 15 HIV-positive patients with acute coronary syndromes. PCI was performed using the study device for de novo coronary lesions with significant size disparity between reference vessel segments. The cumulative incidence of major adverse cardiovascular events (MACE), defined as cardiac death, myocardial infarction, and clinically driven target-lesion revascularization (CD-TLR), was the primary endpoint. Results: Since 2018, 15 HIV-positive patients with a mean age of 50.67 years underwent PCI with the study device. Despite cardiac risk factors and complex lesions, 100 % procedural and device success was achieved by restoring myocardial flow (TIMI flow III). Over a median follow-up of 40 months, no MACE or adverse events were recorded. Conclusions: This study provides new evidence on the use of the long, tapered SES for treating HIV-positive patients, demonstrating high success rates and favorable long-term outcomes. It is the first report of such outcomes using a long, tapered SES in this population.http://www.sciencedirect.com/science/article/pii/S0019483225000471Coronary artery diseaseDrug-eluting stentHuman immunodeficiency virusTapered coronary stentsPercutaneous coronary intervention |
| spellingShingle | H.S. Natraj Setty B.H. Natesh M.C. Yeriswamy V.A. Sathwik Raj Rahul S. Patil H.B. Chetan Kumar L. Sridhar Shastry B.C. Srinivas Babu Reddy Jayashree Kharge C.M. Nagesh S. Manohar C.M. Satwik K.H. Srinivas Santhosh Jadav K.S. Subramani Sadanand Vijay Kumar K.S. Ravindranath Feasibility and outcomes of PCI with novel tapered coronary stent in people living with HIV: A prospective, single-center study with literature review Indian Heart Journal Coronary artery disease Drug-eluting stent Human immunodeficiency virus Tapered coronary stents Percutaneous coronary intervention |
| title | Feasibility and outcomes of PCI with novel tapered coronary stent in people living with HIV: A prospective, single-center study with literature review |
| title_full | Feasibility and outcomes of PCI with novel tapered coronary stent in people living with HIV: A prospective, single-center study with literature review |
| title_fullStr | Feasibility and outcomes of PCI with novel tapered coronary stent in people living with HIV: A prospective, single-center study with literature review |
| title_full_unstemmed | Feasibility and outcomes of PCI with novel tapered coronary stent in people living with HIV: A prospective, single-center study with literature review |
| title_short | Feasibility and outcomes of PCI with novel tapered coronary stent in people living with HIV: A prospective, single-center study with literature review |
| title_sort | feasibility and outcomes of pci with novel tapered coronary stent in people living with hiv a prospective single center study with literature review |
| topic | Coronary artery disease Drug-eluting stent Human immunodeficiency virus Tapered coronary stents Percutaneous coronary intervention |
| url | http://www.sciencedirect.com/science/article/pii/S0019483225000471 |
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