Development of a novelly selective HPLC-chemiluminescence method by targeting degradation intermediates of nitroimidazoles and its application in animal food products
Residues of nitro-containing drugs in food and the environment have aroused social concern because of their excessive use for the treatment of human and animal diseases. The disadvantages of complex and time-consuming pretreatments in existing methods make it imperative to develop novel methods. Her...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Food Chemistry: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590157525000513 |
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| author | Mengdie Cai Xinyu Wang Kun Lu Bixiao Zhou Lijun Wei Xianglei Cheng |
| author_facet | Mengdie Cai Xinyu Wang Kun Lu Bixiao Zhou Lijun Wei Xianglei Cheng |
| author_sort | Mengdie Cai |
| collection | DOAJ |
| description | Residues of nitro-containing drugs in food and the environment have aroused social concern because of their excessive use for the treatment of human and animal diseases. The disadvantages of complex and time-consuming pretreatments in existing methods make it imperative to develop novel methods. Herein, with the aid of recognition probe MCLA, an excellent selective method for the detection of nitroimidazoles (NDZs) was developed based on high-performance liquid chromatography combined with ultraviolet (UV) degradation and chemiluminescence (HPLC-UV-CL). The study proposed an innovative process for the formation of SO4•−, •OH, and •NO via advanced oxidation processes of NDZs. Six studied NDZs achieved baseline separation within 24 min with detection limits as low as 3 ng/mL (S/N = 3). The proposed method is efficient, cost-effective, and does not require complicated purification steps. This study presents a unique approach for the detection of nitro-containing contaminants and provides new insights into monitoring advanced oxidation processes. |
| format | Article |
| id | doaj-art-d88ef7acce154d468448bdb76fd3c29a |
| institution | Kabale University |
| issn | 2590-1575 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Food Chemistry: X |
| spelling | doaj-art-d88ef7acce154d468448bdb76fd3c29a2025-02-12T05:32:34ZengElsevierFood Chemistry: X2590-15752025-01-0125102205Development of a novelly selective HPLC-chemiluminescence method by targeting degradation intermediates of nitroimidazoles and its application in animal food productsMengdie Cai0Xinyu Wang1Kun Lu2Bixiao Zhou3Lijun Wei4Xianglei Cheng5Jiangxi Province Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang 330006, China.Jiangxi Province Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang 330006, China.Jiangxi Province Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang 330006, China.Jiangxi Province Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang 330006, China.Corresponding authors at: School of Public Health, Nanchang University, 461 Bayi Road, Nanchang, 330006, PR China.; Jiangxi Province Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang 330006, China.Corresponding authors at: School of Public Health, Nanchang University, 461 Bayi Road, Nanchang, 330006, PR China.; Jiangxi Province Key Laboratory of Preventive Medicine, School of Public Health, Nanchang University, Nanchang 330006, China.Residues of nitro-containing drugs in food and the environment have aroused social concern because of their excessive use for the treatment of human and animal diseases. The disadvantages of complex and time-consuming pretreatments in existing methods make it imperative to develop novel methods. Herein, with the aid of recognition probe MCLA, an excellent selective method for the detection of nitroimidazoles (NDZs) was developed based on high-performance liquid chromatography combined with ultraviolet (UV) degradation and chemiluminescence (HPLC-UV-CL). The study proposed an innovative process for the formation of SO4•−, •OH, and •NO via advanced oxidation processes of NDZs. Six studied NDZs achieved baseline separation within 24 min with detection limits as low as 3 ng/mL (S/N = 3). The proposed method is efficient, cost-effective, and does not require complicated purification steps. This study presents a unique approach for the detection of nitro-containing contaminants and provides new insights into monitoring advanced oxidation processes.http://www.sciencedirect.com/science/article/pii/S2590157525000513NitroimidazolesMechanismHPLC-Chemiluminescence detectionUV photolysis |
| spellingShingle | Mengdie Cai Xinyu Wang Kun Lu Bixiao Zhou Lijun Wei Xianglei Cheng Development of a novelly selective HPLC-chemiluminescence method by targeting degradation intermediates of nitroimidazoles and its application in animal food products Food Chemistry: X Nitroimidazoles Mechanism HPLC-Chemiluminescence detection UV photolysis |
| title | Development of a novelly selective HPLC-chemiluminescence method by targeting degradation intermediates of nitroimidazoles and its application in animal food products |
| title_full | Development of a novelly selective HPLC-chemiluminescence method by targeting degradation intermediates of nitroimidazoles and its application in animal food products |
| title_fullStr | Development of a novelly selective HPLC-chemiluminescence method by targeting degradation intermediates of nitroimidazoles and its application in animal food products |
| title_full_unstemmed | Development of a novelly selective HPLC-chemiluminescence method by targeting degradation intermediates of nitroimidazoles and its application in animal food products |
| title_short | Development of a novelly selective HPLC-chemiluminescence method by targeting degradation intermediates of nitroimidazoles and its application in animal food products |
| title_sort | development of a novelly selective hplc chemiluminescence method by targeting degradation intermediates of nitroimidazoles and its application in animal food products |
| topic | Nitroimidazoles Mechanism HPLC-Chemiluminescence detection UV photolysis |
| url | http://www.sciencedirect.com/science/article/pii/S2590157525000513 |
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