Impact of influenza-like illnesses on health state utility value among Japanese children and adults
Abstract Purpose For future health technology assessment, an assessment of the utility value of influenza-like illnesses (ILIs) is crucial. Therefore, the objective of this study was to evaluate the impact of ILIs on utility value in a Japanese population. Methods We conducted an online survey betwe...
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SpringerOpen
2025-07-01
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| Series: | Journal of Patient-Reported Outcomes |
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| Online Access: | https://doi.org/10.1186/s41687-025-00917-x |
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| author | Taito Kitano Shinya Tsuzuki |
| author_facet | Taito Kitano Shinya Tsuzuki |
| author_sort | Taito Kitano |
| collection | DOAJ |
| description | Abstract Purpose For future health technology assessment, an assessment of the utility value of influenza-like illnesses (ILIs) is crucial. Therefore, the objective of this study was to evaluate the impact of ILIs on utility value in a Japanese population. Methods We conducted an online survey between March and June 2024 to evaluate the impacts of ILIs on health-related quality of life, using a Japanese version of the EuroQol 5 Dimensions 5 Levels (EQ-5D-5 L) and EuroQol visual analog scale (EQ-VAS). Participants were children and adults aged < 80 years who experienced ILI symptoms or required home isolation due to a respiratory infection. A follow-up survey was conducted 2–3 weeks after the first survey to assess recovery. For children, we asked their parents or guardians to answer as the child’s proxy. A generalized linear model was used to assess the impact of patient demographics, type and onset of symptoms and diagnosis on disutility. Results In total, 392 participants answered the first survey, and 264 participants answered the follow-up survey (134 adult participants and 130 parents or guardians). Compared with those who only answered the first survey, those who also answered the follow-up survey were older and more likely to be male in adult participants. The mean differences in the utility value and VAS scores between the first and follow-up surveys were − 0.055 and − 10.6 in the adult samples and − 0.079 and − 17.9 in the pediatric samples, respectively. In the generalized linear model, symptom onset within 7 days in the first survey was significantly associated with disutility value (coefficient − 0.049 [95% confidence interval [CI] − 0.086 to − 0.012], p = 0.010). However, none of the patient demographics were significantly associated with disutility value. Conclusion Utility values were lower during the symptomatic phase compared with the recovery phase. Our results are useful for disease burden assessment, health technology assessment, and cost-effectiveness analysis, which can support decision-making on the preventive and therapeutic management of respiratory infections. |
| format | Article |
| id | doaj-art-d88c9e12fef043d78e714ecb9d750737 |
| institution | Kabale University |
| issn | 2509-8020 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Patient-Reported Outcomes |
| spelling | doaj-art-d88c9e12fef043d78e714ecb9d7507372025-08-20T03:43:21ZengSpringerOpenJournal of Patient-Reported Outcomes2509-80202025-07-01911810.1186/s41687-025-00917-xImpact of influenza-like illnesses on health state utility value among Japanese children and adultsTaito Kitano0Shinya Tsuzuki1AMR Clinical Reference Center, National Center for Global Health and Medicine, Japan Institute for Health SecurityAMR Clinical Reference Center, National Center for Global Health and Medicine, Japan Institute for Health SecurityAbstract Purpose For future health technology assessment, an assessment of the utility value of influenza-like illnesses (ILIs) is crucial. Therefore, the objective of this study was to evaluate the impact of ILIs on utility value in a Japanese population. Methods We conducted an online survey between March and June 2024 to evaluate the impacts of ILIs on health-related quality of life, using a Japanese version of the EuroQol 5 Dimensions 5 Levels (EQ-5D-5 L) and EuroQol visual analog scale (EQ-VAS). Participants were children and adults aged < 80 years who experienced ILI symptoms or required home isolation due to a respiratory infection. A follow-up survey was conducted 2–3 weeks after the first survey to assess recovery. For children, we asked their parents or guardians to answer as the child’s proxy. A generalized linear model was used to assess the impact of patient demographics, type and onset of symptoms and diagnosis on disutility. Results In total, 392 participants answered the first survey, and 264 participants answered the follow-up survey (134 adult participants and 130 parents or guardians). Compared with those who only answered the first survey, those who also answered the follow-up survey were older and more likely to be male in adult participants. The mean differences in the utility value and VAS scores between the first and follow-up surveys were − 0.055 and − 10.6 in the adult samples and − 0.079 and − 17.9 in the pediatric samples, respectively. In the generalized linear model, symptom onset within 7 days in the first survey was significantly associated with disutility value (coefficient − 0.049 [95% confidence interval [CI] − 0.086 to − 0.012], p = 0.010). However, none of the patient demographics were significantly associated with disutility value. Conclusion Utility values were lower during the symptomatic phase compared with the recovery phase. Our results are useful for disease burden assessment, health technology assessment, and cost-effectiveness analysis, which can support decision-making on the preventive and therapeutic management of respiratory infections.https://doi.org/10.1186/s41687-025-00917-xInfluenza-like illnessHealth-related quality of lifePopulation normJapan |
| spellingShingle | Taito Kitano Shinya Tsuzuki Impact of influenza-like illnesses on health state utility value among Japanese children and adults Journal of Patient-Reported Outcomes Influenza-like illness Health-related quality of life Population norm Japan |
| title | Impact of influenza-like illnesses on health state utility value among Japanese children and adults |
| title_full | Impact of influenza-like illnesses on health state utility value among Japanese children and adults |
| title_fullStr | Impact of influenza-like illnesses on health state utility value among Japanese children and adults |
| title_full_unstemmed | Impact of influenza-like illnesses on health state utility value among Japanese children and adults |
| title_short | Impact of influenza-like illnesses on health state utility value among Japanese children and adults |
| title_sort | impact of influenza like illnesses on health state utility value among japanese children and adults |
| topic | Influenza-like illness Health-related quality of life Population norm Japan |
| url | https://doi.org/10.1186/s41687-025-00917-x |
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