Potential therapeutic effects of milk thistle (Silybum marianum) in eye diseases, a scoping review
Abstract This review aims to evaluate the current literature on the potential therapeutic effects of milk thistle (Silybum marianum) in treating eye diseases and to identify the pharmacologic activities related to ocular diseases. To conduct this scoping review, a comprehensive literature search was...
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| Format: | Article |
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Springer
2024-12-01
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| Series: | Discover Applied Sciences |
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| Online Access: | https://doi.org/10.1007/s42452-024-06401-3 |
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| author | Zahra Tahmasbi Mohadese Boroughani Mohamad Mahdi Heidari Ehsan Namvar Mohammad Hashem Hashempur Seyed Nooreddin Faraji Mostafa Nazarpour-Servak Mojtaba Heydari |
| author_facet | Zahra Tahmasbi Mohadese Boroughani Mohamad Mahdi Heidari Ehsan Namvar Mohammad Hashem Hashempur Seyed Nooreddin Faraji Mostafa Nazarpour-Servak Mojtaba Heydari |
| author_sort | Zahra Tahmasbi |
| collection | DOAJ |
| description | Abstract This review aims to evaluate the current literature on the potential therapeutic effects of milk thistle (Silybum marianum) in treating eye diseases and to identify the pharmacologic activities related to ocular diseases. To conduct this scoping review, a comprehensive literature search was conducted using electronic databases including PubMed, Scopus, Google Scholar, and Web of Science. The search terms used included “Silybum marianum”, “milk thistle”, “eye diseases”, “cataracts”, “age-related macular degeneration”, and “glaucoma.” Inclusion criteria were in-vitro, in-vivo, or human studies investigating the potential therapeutic effects of Silybum marianum in ocular diseases. Studies not related to ocular diseases or not investigating the use of Silybum marianum as a therapeutic agent were excluded. Milk thistle has been found to have various therapeutic effects in treating ocular surface diseases, cataracts, glaucoma, and uveitis. Its pharmacologic activities related to ocular diseases include anti-inflammatory, antioxidant, and antibacterial activities. It also has anti-VEGF (vascular endothelial growth factor) and aldose reductase inhibitor characteristics, which may be beneficial in treating some eye diseases. The appropriate dose and route of administration of milk thistle have also been identified. Milk thistle might be a potentially effective therapeutic agent for various eye diseases. However, further research is needed to fully understand its safety and effectiveness. Milk thistle represents a promising avenue for future research in the field of natural products and the treatment of eye diseases. Graphical Abstract |
| format | Article |
| id | doaj-art-d88c0b921bf34dd49ec64f27caee3456 |
| institution | OA Journals |
| issn | 3004-9261 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Applied Sciences |
| spelling | doaj-art-d88c0b921bf34dd49ec64f27caee34562025-08-20T02:31:38ZengSpringerDiscover Applied Sciences3004-92612024-12-017111410.1007/s42452-024-06401-3Potential therapeutic effects of milk thistle (Silybum marianum) in eye diseases, a scoping reviewZahra Tahmasbi0Mohadese Boroughani1Mohamad Mahdi Heidari2Ehsan Namvar3Mohammad Hashem Hashempur4Seyed Nooreddin Faraji5Mostafa Nazarpour-Servak6Mojtaba Heydari7Student Research Committee, Shiraz University of Medical SciencesStudent Research Committee, Shiraz University of Medical SciencesStudent Research Committee, Shiraz University of Medical SciencesPoostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical SciencesResearch Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical SciencesResearch Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical SciencesPoostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical SciencesPoostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical SciencesAbstract This review aims to evaluate the current literature on the potential therapeutic effects of milk thistle (Silybum marianum) in treating eye diseases and to identify the pharmacologic activities related to ocular diseases. To conduct this scoping review, a comprehensive literature search was conducted using electronic databases including PubMed, Scopus, Google Scholar, and Web of Science. The search terms used included “Silybum marianum”, “milk thistle”, “eye diseases”, “cataracts”, “age-related macular degeneration”, and “glaucoma.” Inclusion criteria were in-vitro, in-vivo, or human studies investigating the potential therapeutic effects of Silybum marianum in ocular diseases. Studies not related to ocular diseases or not investigating the use of Silybum marianum as a therapeutic agent were excluded. Milk thistle has been found to have various therapeutic effects in treating ocular surface diseases, cataracts, glaucoma, and uveitis. Its pharmacologic activities related to ocular diseases include anti-inflammatory, antioxidant, and antibacterial activities. It also has anti-VEGF (vascular endothelial growth factor) and aldose reductase inhibitor characteristics, which may be beneficial in treating some eye diseases. The appropriate dose and route of administration of milk thistle have also been identified. Milk thistle might be a potentially effective therapeutic agent for various eye diseases. However, further research is needed to fully understand its safety and effectiveness. Milk thistle represents a promising avenue for future research in the field of natural products and the treatment of eye diseases. Graphical Abstracthttps://doi.org/10.1007/s42452-024-06401-3Milk thistleSilybum marianumSilymarinEye diseasesCataractGlaucoma |
| spellingShingle | Zahra Tahmasbi Mohadese Boroughani Mohamad Mahdi Heidari Ehsan Namvar Mohammad Hashem Hashempur Seyed Nooreddin Faraji Mostafa Nazarpour-Servak Mojtaba Heydari Potential therapeutic effects of milk thistle (Silybum marianum) in eye diseases, a scoping review Discover Applied Sciences Milk thistle Silybum marianum Silymarin Eye diseases Cataract Glaucoma |
| title | Potential therapeutic effects of milk thistle (Silybum marianum) in eye diseases, a scoping review |
| title_full | Potential therapeutic effects of milk thistle (Silybum marianum) in eye diseases, a scoping review |
| title_fullStr | Potential therapeutic effects of milk thistle (Silybum marianum) in eye diseases, a scoping review |
| title_full_unstemmed | Potential therapeutic effects of milk thistle (Silybum marianum) in eye diseases, a scoping review |
| title_short | Potential therapeutic effects of milk thistle (Silybum marianum) in eye diseases, a scoping review |
| title_sort | potential therapeutic effects of milk thistle silybum marianum in eye diseases a scoping review |
| topic | Milk thistle Silybum marianum Silymarin Eye diseases Cataract Glaucoma |
| url | https://doi.org/10.1007/s42452-024-06401-3 |
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