Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes
We aimed at comparing the relationship of reduced estimated glomerular filtration rate (eGFR) with cardiovascular disease (CVD) and mortality between high risk patients with and without type 2 diabetes mellitus (T2DM). The cross-sectional study evaluated 16,298 participants (1,627 T2DM) acutely admi...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2016/7180784 |
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| author | Attilio Losito Loretta Pittavini Ivano Zampi Elena Zampi |
| author_facet | Attilio Losito Loretta Pittavini Ivano Zampi Elena Zampi |
| author_sort | Attilio Losito |
| collection | DOAJ |
| description | We aimed at comparing the relationship of reduced estimated glomerular filtration rate (eGFR) with cardiovascular disease (CVD) and mortality between high risk patients with and without type 2 diabetes mellitus (T2DM). The cross-sectional study evaluated 16,298 participants (1,627 T2DM) acutely admitted to hospital. The longitudinal study comprised 7,508 patients (673 with diabetes and 6,835 without). eGFR was categorized into 6 stages from >90 to <15 mL/min/1.73 m2. Kidney dysfunction was defined by an eGFR < 60 mL/min/1.73 m2. Patients with T2D showed a higher prevalence of CVD (37.9% versus 23.6%; P<0.001) and kidney dysfunction (25% versus 13.2%; P<0.001) than in the general population. An association with CVD was found with eGFR stages from 30 to 90 mL/min/1.73 m2 in T2D and from <15 to 90 mL/min/1.73 m2 in general population, in whom the association of eGFR with coronary heart disease was in an inverse relationship (P<0.01 for trend). Survival, in diabetes, was lower (P=0.037) but not associated with kidney dysfunction. Conclusions. In a high risk population, patients admitted to hospital, the relationship of kidney function with CVD is different between T2D and the general population. Competing mortality and the presence of other major risk factors in diabetes may be responsible for this difference. |
| format | Article |
| id | doaj-art-d886d2a05a0349f2ad80b60278bf9fd0 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-d886d2a05a0349f2ad80b60278bf9fd02025-02-03T06:12:28ZengWileyInternational Journal of Nephrology2090-214X2090-21582016-01-01201610.1155/2016/71807847180784Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with DiabetesAttilio Losito0Loretta Pittavini1Ivano Zampi2Elena Zampi3Renal Unit, Santa Maria Della Misericordia Hospital, Perugia, ItalyRenal Unit, Santa Maria Della Misericordia Hospital, Perugia, ItalyInstitute of Geriatrics and Gerontology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale S. Maria della Misericordia, Perugia, ItalyDepartment of Medicine, Hospital of Pantalla, Todi, ItalyWe aimed at comparing the relationship of reduced estimated glomerular filtration rate (eGFR) with cardiovascular disease (CVD) and mortality between high risk patients with and without type 2 diabetes mellitus (T2DM). The cross-sectional study evaluated 16,298 participants (1,627 T2DM) acutely admitted to hospital. The longitudinal study comprised 7,508 patients (673 with diabetes and 6,835 without). eGFR was categorized into 6 stages from >90 to <15 mL/min/1.73 m2. Kidney dysfunction was defined by an eGFR < 60 mL/min/1.73 m2. Patients with T2D showed a higher prevalence of CVD (37.9% versus 23.6%; P<0.001) and kidney dysfunction (25% versus 13.2%; P<0.001) than in the general population. An association with CVD was found with eGFR stages from 30 to 90 mL/min/1.73 m2 in T2D and from <15 to 90 mL/min/1.73 m2 in general population, in whom the association of eGFR with coronary heart disease was in an inverse relationship (P<0.01 for trend). Survival, in diabetes, was lower (P=0.037) but not associated with kidney dysfunction. Conclusions. In a high risk population, patients admitted to hospital, the relationship of kidney function with CVD is different between T2D and the general population. Competing mortality and the presence of other major risk factors in diabetes may be responsible for this difference.http://dx.doi.org/10.1155/2016/7180784 |
| spellingShingle | Attilio Losito Loretta Pittavini Ivano Zampi Elena Zampi Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes International Journal of Nephrology |
| title | Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes |
| title_full | Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes |
| title_fullStr | Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes |
| title_full_unstemmed | Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes |
| title_short | Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes |
| title_sort | characteristics of the relationship of kidney dysfunction with cardiovascular disease in high risk patients with diabetes |
| url | http://dx.doi.org/10.1155/2016/7180784 |
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