Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes

We aimed at comparing the relationship of reduced estimated glomerular filtration rate (eGFR) with cardiovascular disease (CVD) and mortality between high risk patients with and without type 2 diabetes mellitus (T2DM). The cross-sectional study evaluated 16,298 participants (1,627 T2DM) acutely admi...

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Main Authors: Attilio Losito, Loretta Pittavini, Ivano Zampi, Elena Zampi
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:International Journal of Nephrology
Online Access:http://dx.doi.org/10.1155/2016/7180784
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author Attilio Losito
Loretta Pittavini
Ivano Zampi
Elena Zampi
author_facet Attilio Losito
Loretta Pittavini
Ivano Zampi
Elena Zampi
author_sort Attilio Losito
collection DOAJ
description We aimed at comparing the relationship of reduced estimated glomerular filtration rate (eGFR) with cardiovascular disease (CVD) and mortality between high risk patients with and without type 2 diabetes mellitus (T2DM). The cross-sectional study evaluated 16,298 participants (1,627 T2DM) acutely admitted to hospital. The longitudinal study comprised 7,508 patients (673 with diabetes and 6,835 without). eGFR was categorized into 6 stages from >90 to <15 mL/min/1.73 m2. Kidney dysfunction was defined by an eGFR < 60 mL/min/1.73 m2. Patients with T2D showed a higher prevalence of CVD (37.9% versus 23.6%; P<0.001) and kidney dysfunction (25% versus 13.2%; P<0.001) than in the general population. An association with CVD was found with eGFR stages from 30 to 90 mL/min/1.73 m2 in T2D and from <15 to 90 mL/min/1.73 m2 in general population, in whom the association of eGFR with coronary heart disease was in an inverse relationship (P<0.01 for trend). Survival, in diabetes, was lower (P=0.037) but not associated with kidney dysfunction. Conclusions. In a high risk population, patients admitted to hospital, the relationship of kidney function with CVD is different between T2D and the general population. Competing mortality and the presence of other major risk factors in diabetes may be responsible for this difference.
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spelling doaj-art-d886d2a05a0349f2ad80b60278bf9fd02025-02-03T06:12:28ZengWileyInternational Journal of Nephrology2090-214X2090-21582016-01-01201610.1155/2016/71807847180784Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with DiabetesAttilio Losito0Loretta Pittavini1Ivano Zampi2Elena Zampi3Renal Unit, Santa Maria Della Misericordia Hospital, Perugia, ItalyRenal Unit, Santa Maria Della Misericordia Hospital, Perugia, ItalyInstitute of Geriatrics and Gerontology, Department of Clinical and Experimental Medicine, University of Perugia, Ospedale S. Maria della Misericordia, Perugia, ItalyDepartment of Medicine, Hospital of Pantalla, Todi, ItalyWe aimed at comparing the relationship of reduced estimated glomerular filtration rate (eGFR) with cardiovascular disease (CVD) and mortality between high risk patients with and without type 2 diabetes mellitus (T2DM). The cross-sectional study evaluated 16,298 participants (1,627 T2DM) acutely admitted to hospital. The longitudinal study comprised 7,508 patients (673 with diabetes and 6,835 without). eGFR was categorized into 6 stages from >90 to <15 mL/min/1.73 m2. Kidney dysfunction was defined by an eGFR < 60 mL/min/1.73 m2. Patients with T2D showed a higher prevalence of CVD (37.9% versus 23.6%; P<0.001) and kidney dysfunction (25% versus 13.2%; P<0.001) than in the general population. An association with CVD was found with eGFR stages from 30 to 90 mL/min/1.73 m2 in T2D and from <15 to 90 mL/min/1.73 m2 in general population, in whom the association of eGFR with coronary heart disease was in an inverse relationship (P<0.01 for trend). Survival, in diabetes, was lower (P=0.037) but not associated with kidney dysfunction. Conclusions. In a high risk population, patients admitted to hospital, the relationship of kidney function with CVD is different between T2D and the general population. Competing mortality and the presence of other major risk factors in diabetes may be responsible for this difference.http://dx.doi.org/10.1155/2016/7180784
spellingShingle Attilio Losito
Loretta Pittavini
Ivano Zampi
Elena Zampi
Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes
International Journal of Nephrology
title Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes
title_full Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes
title_fullStr Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes
title_full_unstemmed Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes
title_short Characteristics of the Relationship of Kidney Dysfunction with Cardiovascular Disease in High Risk Patients with Diabetes
title_sort characteristics of the relationship of kidney dysfunction with cardiovascular disease in high risk patients with diabetes
url http://dx.doi.org/10.1155/2016/7180784
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AT ivanozampi characteristicsoftherelationshipofkidneydysfunctionwithcardiovasculardiseaseinhighriskpatientswithdiabetes
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