Mechanisms of Senescence and Anti-Senescence Strategies in the Skin
The skin is the layer of tissue that covers the largest part of the body in vertebrates, and its main function is to act as a protective barrier against external environmental factors, such as microorganisms, ultraviolet light and mechanical damage. Due to its important function, investigating the f...
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MDPI AG
2024-08-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/13/9/647 |
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| author | Evangelia Konstantinou Eliane Longange Gürkan Kaya |
| author_facet | Evangelia Konstantinou Eliane Longange Gürkan Kaya |
| author_sort | Evangelia Konstantinou |
| collection | DOAJ |
| description | The skin is the layer of tissue that covers the largest part of the body in vertebrates, and its main function is to act as a protective barrier against external environmental factors, such as microorganisms, ultraviolet light and mechanical damage. Due to its important function, investigating the factors that lead to skin aging and age-related diseases, as well as understanding the biology of this process, is of high importance. Indeed, it has been reported that several external and internal stressors contribute to skin aging, similar to the aging of other tissues. Moreover, during aging, senescent cells accumulate in the skin and express senescence-associated factors, which act in a paracrine manner on neighboring healthy cells and tissues. In this review, we will present the factors that lead to skin aging and cellular senescence, as well as ways to study senescence in vitro and in vivo. We will further discuss the adverse effects of the accumulation of chronic senescent cells and therapeutic agents and tools to selectively target and eliminate them. |
| format | Article |
| id | doaj-art-d8831800a52a4cce97efd58555cf4068 |
| institution | OA Journals |
| issn | 2079-7737 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-d8831800a52a4cce97efd58555cf40682025-08-20T01:56:05ZengMDPI AGBiology2079-77372024-08-0113964710.3390/biology13090647Mechanisms of Senescence and Anti-Senescence Strategies in the SkinEvangelia Konstantinou0Eliane Longange1Gürkan Kaya2Department of Medicine, University of Geneva, Rue Michel-Servet 1, CH-1206 Geneva, SwitzerlandDepartment of Medicine, University of Geneva, Rue Michel-Servet 1, CH-1206 Geneva, SwitzerlandDepartment of Medicine, University of Geneva, Rue Michel-Servet 1, CH-1206 Geneva, SwitzerlandThe skin is the layer of tissue that covers the largest part of the body in vertebrates, and its main function is to act as a protective barrier against external environmental factors, such as microorganisms, ultraviolet light and mechanical damage. Due to its important function, investigating the factors that lead to skin aging and age-related diseases, as well as understanding the biology of this process, is of high importance. Indeed, it has been reported that several external and internal stressors contribute to skin aging, similar to the aging of other tissues. Moreover, during aging, senescent cells accumulate in the skin and express senescence-associated factors, which act in a paracrine manner on neighboring healthy cells and tissues. In this review, we will present the factors that lead to skin aging and cellular senescence, as well as ways to study senescence in vitro and in vivo. We will further discuss the adverse effects of the accumulation of chronic senescent cells and therapeutic agents and tools to selectively target and eliminate them.https://www.mdpi.com/2079-7737/13/9/647skin agingcellular senescenceSASPp16INK4asenolyticssenomorphics |
| spellingShingle | Evangelia Konstantinou Eliane Longange Gürkan Kaya Mechanisms of Senescence and Anti-Senescence Strategies in the Skin Biology skin aging cellular senescence SASP p16INK4a senolytics senomorphics |
| title | Mechanisms of Senescence and Anti-Senescence Strategies in the Skin |
| title_full | Mechanisms of Senescence and Anti-Senescence Strategies in the Skin |
| title_fullStr | Mechanisms of Senescence and Anti-Senescence Strategies in the Skin |
| title_full_unstemmed | Mechanisms of Senescence and Anti-Senescence Strategies in the Skin |
| title_short | Mechanisms of Senescence and Anti-Senescence Strategies in the Skin |
| title_sort | mechanisms of senescence and anti senescence strategies in the skin |
| topic | skin aging cellular senescence SASP p16INK4a senolytics senomorphics |
| url | https://www.mdpi.com/2079-7737/13/9/647 |
| work_keys_str_mv | AT evangeliakonstantinou mechanismsofsenescenceandantisenescencestrategiesintheskin AT elianelongange mechanismsofsenescenceandantisenescencestrategiesintheskin AT gurkankaya mechanismsofsenescenceandantisenescencestrategiesintheskin |