Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages

Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages

Abstract In recent decades, drug resistant (DR) strains of Mycobacterium tuberculosis (M.tb), the cause of tuberculosis (TB), have emerged that threaten public health. Although M.tb‘s complex and protective cell envelope has been widely studied, little is known about how levels of peripheral lipids...

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Bibliographic Details
Main Authors: Alyssa Schami, M. Nurul Islam, Matthew Wall, Amberlee Hicks, Reagan Meredith, Barry Kreiswirth, Barun Mathema, John T. Belisle, Jordi B. Torrelles
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Mycobacterium tuberculosis
Drug resistance
Cell envelope composition
Phthiocerol dimycocerosates
Phosphatidyl-myo-inositol mannosides
Tuberculosis
Online Access:https://doi.org/10.1038/s41598-024-81457-0
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