Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction Databases
Prostate cancer (PC) represents the second most common diagnosed cancer in men. The burden of diagnosis and long-term treatment may frequently cause psychiatric disorders in patients, particularly depression. The most common PC treatment option is androgen deprivation therapy (ADT), which may be ass...
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2024-09-01
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| author | Daniel Ungureanu Adina Popa Adina Nemeș Cătălina-Angela Crișan |
| author_facet | Daniel Ungureanu Adina Popa Adina Nemeș Cătălina-Angela Crișan |
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| description | Prostate cancer (PC) represents the second most common diagnosed cancer in men. The burden of diagnosis and long-term treatment may frequently cause psychiatric disorders in patients, particularly depression. The most common PC treatment option is androgen deprivation therapy (ADT), which may be associated with taxane chemotherapy. In patients with both PC and psychiatric disorders, polypharmacy is frequently present, which increases the risk of drug–drug interactions (DDIs) and drug-related adverse effects. Therefore, this study aimed to conduct a pharmacoepidemiologic study of the concomitant administration of PC drugs and psychotropics using three drug interaction databases (Lexicomp<sup>®</sup>, drugs.com<sup>®</sup>, and Medscape<sup>®</sup>). This study assayed 4320 drug–drug combinations (DDCs) and identified 814 DDIs, out of which 405 (49.63%) were pharmacokinetic (PK) interactions and 411 (50.37%) were pharmacodynamic (PD) interactions. The most common PK interactions were based on CYP3A4 induction (<i>n</i> = 275, 67.90%), while the most common PD interactions were based on additive torsadogenicity (<i>n</i> = 391, 95.13%). Proposed measures for managing the identified DDIs included dose adjustments, drug substitutions, supplementary agents, parameters monitoring, or simply the avoidance of a given DDC. A significant heterogenicity was observed between the selected drug interaction databases, which can be mitigated by cross-referencing multiple databases in clinical practice. |
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| spelling | doaj-art-d87da5ea653b400baed27074dc0edccc2025-08-20T01:56:05ZengMDPI AGBiomedicines2227-90592024-09-01129197110.3390/biomedicines12091971Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction DatabasesDaniel Ungureanu0Adina Popa1Adina Nemeș2Cătălina-Angela Crișan3Department Pharmacy I, Discipline of Pharmaceutical Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, 41 Victor Babeș Street, 400012 Cluj-Napoca, RomaniaDepartment Pharmacy II, Discipline of Clinical Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 12 Ion Creangă Street, 400010 Cluj-Napoca, Romania“Prof. Dr. Ion Chiricuță” Oncology Institute, 34-36 Republicii Street, 400015 Cluj-Napoca, RomaniaDepartment of Neurosciences, Discipline of Psychiatry and Pediatric Psychiatry, “Iuliu Hațieganu” University of Medicine and Pharmacy, 43 Victor Babeș Street, 400012 Cluj-Napoca, RomaniaProstate cancer (PC) represents the second most common diagnosed cancer in men. The burden of diagnosis and long-term treatment may frequently cause psychiatric disorders in patients, particularly depression. The most common PC treatment option is androgen deprivation therapy (ADT), which may be associated with taxane chemotherapy. In patients with both PC and psychiatric disorders, polypharmacy is frequently present, which increases the risk of drug–drug interactions (DDIs) and drug-related adverse effects. Therefore, this study aimed to conduct a pharmacoepidemiologic study of the concomitant administration of PC drugs and psychotropics using three drug interaction databases (Lexicomp<sup>®</sup>, drugs.com<sup>®</sup>, and Medscape<sup>®</sup>). This study assayed 4320 drug–drug combinations (DDCs) and identified 814 DDIs, out of which 405 (49.63%) were pharmacokinetic (PK) interactions and 411 (50.37%) were pharmacodynamic (PD) interactions. The most common PK interactions were based on CYP3A4 induction (<i>n</i> = 275, 67.90%), while the most common PD interactions were based on additive torsadogenicity (<i>n</i> = 391, 95.13%). Proposed measures for managing the identified DDIs included dose adjustments, drug substitutions, supplementary agents, parameters monitoring, or simply the avoidance of a given DDC. A significant heterogenicity was observed between the selected drug interaction databases, which can be mitigated by cross-referencing multiple databases in clinical practice.https://www.mdpi.com/2227-9059/12/9/1971prostate cancerpsychotropic drugdrug–drug interactionpharmacokinetic interactionspharmacodynamic interactionsCYP3A4 induction |
| spellingShingle | Daniel Ungureanu Adina Popa Adina Nemeș Cătălina-Angela Crișan Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction Databases Biomedicines prostate cancer psychotropic drug drug–drug interaction pharmacokinetic interactions pharmacodynamic interactions CYP3A4 induction |
| title | Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction Databases |
| title_full | Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction Databases |
| title_fullStr | Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction Databases |
| title_full_unstemmed | Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction Databases |
| title_short | Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction Databases |
| title_sort | concomitant administration of psychotropic and prostate cancer drugs a pharmacoepidemiologic study using drug drug interaction databases |
| topic | prostate cancer psychotropic drug drug–drug interaction pharmacokinetic interactions pharmacodynamic interactions CYP3A4 induction |
| url | https://www.mdpi.com/2227-9059/12/9/1971 |
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