Pleural Mesothelioma Presenting as Periumbilical Metastasis: The First Clinical Documentation
Introduction. Pleural mesothelioma with metastasis to the subcutaneous tissue of the abdominal wall at first diagnosis and without penetration into the peritoneum is an extremely rare clinical presentation. Methods. Patients with pleural mesothelioma have low survival rate. Usually, the disease at p...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/198729 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849683490888482816 |
|---|---|
| author | R. F. Falkenstern-Ge M. Kimmich S. Bode-Erdmann G. Friedel G. Ott M. Kohlhäufl |
| author_facet | R. F. Falkenstern-Ge M. Kimmich S. Bode-Erdmann G. Friedel G. Ott M. Kohlhäufl |
| author_sort | R. F. Falkenstern-Ge |
| collection | DOAJ |
| description | Introduction. Pleural mesothelioma with metastasis to the subcutaneous tissue of the abdominal wall at first diagnosis and without penetration into the peritoneum is an extremely rare clinical presentation. Methods. Patients with pleural mesothelioma have low survival rate. Usually, the disease at presentation is confined to its site of origin (most often the pleural cavity). A 55-year-old man was referred to our center due to increasing dyspnea and a painful periumbilical mass in the anterior abdominal wall. CT scan revealed both advanced mesothelioma of the pleura and a tumor mass confined to the subcutaneous fatty tissue without penetration through the peritoneum. Results. Video-assisted thoracoscopy confirmed the diagnosis of epithelioid pleural mesothelioma, which was also confirmed by a biopsy of the periumbilical mass. Systemic chemotherapy with cisplatin and pemetrexed was initiated. Under the ongoing systemic chemotherapy, the evaluation revealed partial remission of pleura mesothelioma and its subcutaneous manifestation of the abdominal wall. Conclusion. Mesothelioma of the pleura with a simultaneous metastasis to the subcutaneous fatty tissue of the abdominal wall at presentation without penetration of peritoneum is a rare clinical presentation of mesothelioma disease. The knowledge of its natural history is very limited. This is the first ever clinical documentation of a patient with pleura mesothelioma and simultaneous subcutaneous manifestation of abdominal wall. |
| format | Article |
| id | doaj-art-d87c705a22f446958c2db40a5b49508e |
| institution | DOAJ |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-d87c705a22f446958c2db40a5b49508e2025-08-20T03:23:51ZengWileyCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/198729198729Pleural Mesothelioma Presenting as Periumbilical Metastasis: The First Clinical DocumentationR. F. Falkenstern-Ge0M. Kimmich1S. Bode-Erdmann2G. Friedel3G. Ott4M. Kohlhäufl5Division of Pulmonology, Klinik Schillerhoehe, Center for Pulmonology and Thoracic Surgery, Teaching Hospital of the University of Tuebingen, Solitude Street 18, Gerlingen, 70839 Stuttgart, GermanyDivision of Pulmonology, Klinik Schillerhoehe, Center for Pulmonology and Thoracic Surgery, Teaching Hospital of the University of Tuebingen, Solitude Street 18, Gerlingen, 70839 Stuttgart, GermanyDivision of Pathology, Robert Bosch Krankenhaus, Teaching Hospital of the University of Tuebingen, Auerbachstrasse 110, 70376 Stuttgart, GermanyDivision of Thoracic Oncology, Klinik Schillerhoehe, Center for Pulmonology and Thoracic Surgery, Teaching Hospital of the University of Tuebingen, Solitude Street 18, Gerlingen, 70839 Stuttgart, GermanyDivision of Clinical Pathology, Robert Bosch Krankenhaus, Teaching Hospital of the University of Tuebingen, Auerbachstrasse 110, 70376 Stuttgart, GermanyDivision of Pulmonology, Klinik Schillerhoehe, Center for Pulmonology and Thoracic Surgery, Teaching Hospital of the University of Tuebingen, Solitude Street 18, Gerlingen, 70839 Stuttgart, GermanyIntroduction. Pleural mesothelioma with metastasis to the subcutaneous tissue of the abdominal wall at first diagnosis and without penetration into the peritoneum is an extremely rare clinical presentation. Methods. Patients with pleural mesothelioma have low survival rate. Usually, the disease at presentation is confined to its site of origin (most often the pleural cavity). A 55-year-old man was referred to our center due to increasing dyspnea and a painful periumbilical mass in the anterior abdominal wall. CT scan revealed both advanced mesothelioma of the pleura and a tumor mass confined to the subcutaneous fatty tissue without penetration through the peritoneum. Results. Video-assisted thoracoscopy confirmed the diagnosis of epithelioid pleural mesothelioma, which was also confirmed by a biopsy of the periumbilical mass. Systemic chemotherapy with cisplatin and pemetrexed was initiated. Under the ongoing systemic chemotherapy, the evaluation revealed partial remission of pleura mesothelioma and its subcutaneous manifestation of the abdominal wall. Conclusion. Mesothelioma of the pleura with a simultaneous metastasis to the subcutaneous fatty tissue of the abdominal wall at presentation without penetration of peritoneum is a rare clinical presentation of mesothelioma disease. The knowledge of its natural history is very limited. This is the first ever clinical documentation of a patient with pleura mesothelioma and simultaneous subcutaneous manifestation of abdominal wall.http://dx.doi.org/10.1155/2013/198729 |
| spellingShingle | R. F. Falkenstern-Ge M. Kimmich S. Bode-Erdmann G. Friedel G. Ott M. Kohlhäufl Pleural Mesothelioma Presenting as Periumbilical Metastasis: The First Clinical Documentation Case Reports in Oncological Medicine |
| title | Pleural Mesothelioma Presenting as Periumbilical Metastasis: The First Clinical Documentation |
| title_full | Pleural Mesothelioma Presenting as Periumbilical Metastasis: The First Clinical Documentation |
| title_fullStr | Pleural Mesothelioma Presenting as Periumbilical Metastasis: The First Clinical Documentation |
| title_full_unstemmed | Pleural Mesothelioma Presenting as Periumbilical Metastasis: The First Clinical Documentation |
| title_short | Pleural Mesothelioma Presenting as Periumbilical Metastasis: The First Clinical Documentation |
| title_sort | pleural mesothelioma presenting as periumbilical metastasis the first clinical documentation |
| url | http://dx.doi.org/10.1155/2013/198729 |
| work_keys_str_mv | AT rffalkensternge pleuralmesotheliomapresentingasperiumbilicalmetastasisthefirstclinicaldocumentation AT mkimmich pleuralmesotheliomapresentingasperiumbilicalmetastasisthefirstclinicaldocumentation AT sbodeerdmann pleuralmesotheliomapresentingasperiumbilicalmetastasisthefirstclinicaldocumentation AT gfriedel pleuralmesotheliomapresentingasperiumbilicalmetastasisthefirstclinicaldocumentation AT gott pleuralmesotheliomapresentingasperiumbilicalmetastasisthefirstclinicaldocumentation AT mkohlhaufl pleuralmesotheliomapresentingasperiumbilicalmetastasisthefirstclinicaldocumentation |